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生物物理学杂志2007年第12期封面 购买


controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants
keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with cxcl1
the advantages of being locked
an undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in escherichia coli
components of the translational machinery are associated with juvenile glycine receptors and are redistributed to the cytoskeleton upon aging and synaptic activity
cytosolic hsp90 regulates the heat shock response that is responsible for heat acclimation in arabidopsis thaliana
hst3 is regulated by mec1-dependent proteolysis and controls the s phase checkpoint and sister chromatid cohesion by deacetylating histone h3 at lysine 56
regulation of platelet-derived growth factor receptor activation by afadin through shp-
c-type lectin-like carbohydrate recognition of the hemolytic lectin cel-iii containing ricin-type β-trefoil folds
identification of a lysosomal peptide transport system induced during dendritic cell development
global disruption of cell cycle progression and nutrient response by the antifungal agent amiodarone
model structure of the na+/h+ exchanger 1 (nhe1)
triadins modulate intracellular ca2+ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle
a novel secondary acyl chain in the lipopolysaccharide of bordetella pertussis required for efficient infection of human macrophages
the deubiquitinating enzyme uch-l3 regulates the apical membrane recycling of the epithelial sodium channel
highly conserved sequences mediate the dynamic interplay of basic helix-loop-helix proteins regulating retinogenesis
characterization of the murine igg fc receptor iii and iib gene promoters
assembly of the yin yang 1 transcription factor into messenger ribonucleoprotein particles requires direct rna binding activity
identification and characterization of a juvenile hormone response element and its binding proteins
role of the subunit of thermophilic f1-atpase as a sensor for atp
comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2
vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1
rbel1 is a novel gene that encodes a nucleocytoplasmic ras superfamily gtp-binding protein and is overexpressed in breast cancer
myod acetylation influences temporal patterns of skeletal muscle gene expression
small cab-like proteins retard degradation of photosystem ii-associated chlorophyll in synechocystis sp. pcc 680
tom1l1 is a lyn substrate involved in fcri signaling in mast cells
differential regulation of the apical plasma membrane ca2+-atpase by protein kinase a in parotid acinar cells
suppression of polyglutamine toxicity by the yeast sup35 prion domain in drosophila
in vitro synthesis of curcuminoids by type iii polyketide synthase from oryza sativa
domain swapping within pdz2 is responsible for dimerization of zo proteins
the structure of a full-length response regulator from mycobacterium tuberculosis in a stabilized three-dimensional domain-swapped, activated state
fertilization and nicotinic acid adenine dinucleotide phosphate induce ph changes in acidic ca2+ stores in sea urchin eggs
peroxisome proliferator-activated receptor (ppar)-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the ret..
53bp2s, interacting with insulin receptor substrates, modulates insulin signaling
the lysophosphatidic acid 2 receptor mediates down-regulation of siva-1 to promote cell survival
stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor signaling is critical to pregnancy success
s-nitrosation of mitochondrial complex i depends on its structural conformation
direct catalysis of lysine 48-linked polyubiquitin chains by the ubiquitin-activating enzyme
functional characterization of mia40p, the central component of the disulfide relay system of the mitochondrial intermembrane space
enhanced excitation-coupled calcium entry in myotubes is associated with expression of ryr1 malignant hyperthermia mutations
exploring the cooperativity of the fast folding reaction of a small protein using pulsed thiol labeling and mass spectrometry
human papillomavirus e7 requires the protease calpain to degrade the retinoblastoma protein
increased glucose disposal and amp-dependent kinase signaling in a mouse model of hemochromatosis
cell wall-linked cryptococcal phospholipase b1 is a source of secreted enzyme and a determinant of cell wall integrity
the interactions of cell division protein ftsz with guanine nucleotides
distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related g-prote..
gpm1p is a factor h-, fhl-1-, and plasminogen-binding surface protein of candida albicans
state-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin
light and oxygen are not required for harpin-induced cell death
a heat shock protein 90 binding domain in endothelial nitric-oxide synthase influences enzyme function
cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of na+/h+ exchanger 3 regulatory factor 1 (nherf-1)- but not nherf-..
a biochemical model of matrix metalloproteinase 9 activation and inhibition
mapping the membrane-aqueous border for the voltage-sensing domain of a potassium channel
bag-1 associates with hsc70·tau complex and regulates the proteasomal degradation of tau protein
heat shock transcription factor 1 is required for maintenance of ciliary beating in mice
the atg12-atg5 conjugate has a novel e3-like activity for protein lipidation in autophagy
synergistic inhibition of mitochondrial respiration by anticancer agent erucylphosphohomocholine and cyclosporin a
a poised initiation complex is activated by snf1
an arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh
characterization of a globin-coupled oxygen sensor with a gene-regulating function
induction of the sumo-specific protease 1 transcription by the androgen receptor in prostate cancer cells
extracellular atp mediates necrotic cell swelling in sn4741 dopaminergic neurons through p2x7 receptors
mammalian gene peg10 expresses two reading frames by high efficiency –1 frameshifting in embryonic-associated tissues
protein kinase a, not epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells
phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disi..
cpeb interacts with an ovary-specific eif4e and 4e-t in early xenopus oocytes
the epithelial sodium channel (enac) traffics to apical membrane in lipid rafts in mouse cortical collecting duct cells
hiv-1 tat activates dual nox pathways leading to independent activation of erk and jnk map kinases
distinguishing aggrecan loss from aggrecan proteolysis in adamts-4 and adamts-5 single and double deficient mice
the activity of p53 is differentially regulated by brm- and brg1-containing swi/snf chromatin remodeling complexes
the cytotoxic lipid peroxidation product 4-hydroxy-2-nonenal covalently modifies a selective range of proteins linked to respiratory function in plant mitochondria
the active site of an algal prolyl 4-hydroxylase has a large structural plasticity
the pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells
a novel structural fold in polysaccharide lyases
ib- represses the transcriptional activity of the hiv-1 tat transactivator by promoting its nuclear export
the lipid droplet binding domain of hepatitis c virus core protein is a major determinant for efficient virus assembly
bone morphogenetic protein 2 opposes shh-mediated proliferation in cerebellar granule cells through a tieg-1-based regulation of nmyc
saccharomyces cerevisiae mutl is a mismatch repair endonuclease
crystal structure of the interleukin-15·interleukin-15 receptor complex
controlling the inhibition of the sarcoplasmic ca2+-atpase by tuning phospholamban structural dynamics
binding of rac1, rnd1, and rhod to a novel rho gtpase interaction motif destabilizes dimerization of the plexin-b1 effector domain
abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor
modulation of f-actin rearrangement by the cyclic amp/camp-dependent protein kinase (pka) pathway is mediated by mapk-activated protein kinase 5 and requires pka-in..
control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors
acetyl-lysine analog peptides as mechanistic probes of protein deacetylases
precursor protein is readily degraded in mitochondrial matrix space if the leader is not processed by mitochondrial processing peptidase
targeted expression of gli1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure
gp120 v3-dependent impairment of r5 hiv-1 infectivity due to virion-incorporated ccr5
fragmentation of proteins in cartilage treated with interleukin-
the m.ecorv dna-(adenine n6)-methyltransferase uses dna bending for recognition of an expanded ecodam recognition site
signaling by toll-like receptors 8 and 9 requires bruton‘s tyrosine kinase
three-dimensional reconstruction using transmission electron microscopy reveals a swollen, bell-shaped structure of transient receptor potential melastatin type 2 c..
arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor cxcr4
dna accelerates the inhibition of human cathepsin v by serpins
site-specific effects of peptide lipidation on β-amyloid aggregation and cytotoxicity
functional interactions between the g‘ subdomain of bacterial translation factor ef-g and ribosomal protein l7/l12
peroxisome proliferator-activated receptor up-regulates the bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against o..
evidence for nifu and nifs participation in the biosynthesis of the iron-molybdenum cofactor of nitrogenase
the cellular functions of the yeast lipin homolog pah1p are dependent on its phosphatidate phosphatase activity
solution structure of selenoprotein w and nmr analysis of its interaction with 14-3-3 proteins
cell type-specific functions of the lysosomal protease cathepsin l in the heart
znt7 (slc30a7)-deficient mice display reduced body zinc status and body fat accumulation
calcineurin promotes hypoxia-inducible factor 1 expression by dephosphorylating rack1 and blocking rack1 dimerization
asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase a
hypermethylation of fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia
crystal structures of blasticidin s deaminase (bsd)
hyaluronan synthases: a decade-plus of novel glycosyltransferases
a point mutation in atpc1 raises the redox potential of the arabidopsis chloroplast atp synthase -subunit regulatory disulfide above the range of thioredoxin modula..
detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration
functional analysis of the interplay between translation termination, selenocysteine codon context, and selenocysteine insertion sequence-binding protein 2
major house dust mite allergens dermatophagoides pteronyssinus 1 and dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins a and d
identification of in vivo phosphorylation sites and their functional significance in the sodium iodide symporter
signal peptide peptidase and -secretase share equivalent inhibitor binding pharmacology
negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-β-dependent modulation of transcription factor tcf11
mitochondrial nd5 gene variation associated with encephalomyopathy and mitochondrial atp consumption
lysophosphatidylcholine metabolism in saccharomyces cerevisiae
hfe modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-hfe interactions
interaction of the dynlt (tctex1/rp3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex
dissecting the facilitator and inhibitor allosteric metal sites of the p2x4 receptor channel
induction of a group 2 factor, rpod3, by high light and the underlying mechanism in synechococcus elongatus pcc 7942
chondroitinase-mediated degradation of rare 3-o-sulfated glucuronic acid in functional oversulfated chondroitin sulfate k and e
novel conantokins from conus parius venom are specific antagonists of n-methyl-d-aspartate receptors
characterization of the nuom (nd4) subunit in escherichia coli ndh-
expression of bisecting type and lewisx/lewisy terminated n-glycans on human sperm
the human monocytic leukemia zinc finger histone acetyltransferase domain contains dna-binding activity implicated in chromatin targeting
isolating the epstein-barr virus gp350/220 binding site on complement receptor type 2 (cr2/cd21)
the crystal structure of d7r4, a salivary biogenic amine-binding protein from the malaria mosquito anopheles gambiae
live-cell molecular analysis of akt activation reveals roles for activation loop phosphorylation
a role for the transcriptional coactivator pgc-1 in muscle refueling
dyp, a unique dye-decolorizing peroxidase, represents a novel heme peroxidase family
tuning of the outer hair cell motor by membrane cholesterol
a suppressive role of the prolyl isomerase pin1 in cellular apoptosis mediated by the death-associated protein daxx
clustering of membrane raft proteins by the actin cytoskeleton
role of task2 in the control of apoptotic volume decrease in proximal kidney cells
highly promiscuous nature of prion polymerization
autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in st14 hypomorphic mice
resistance to neutralization by antibodies targeting the coiled coil of fusion-active envelope is a common feature of retroviruses
in-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence
ebp1 association with nucleophosmin/b23 is essential for regulating cell proliferation and suppressing apoptosis
activin regulates estrogen receptor gene expression in the mouse ovary
induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor synthetic ligands in mouse liver
structure and activity of y-class dna polymerase dpo4 from sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene
substitution of tyrosine 146 in the di component of proton-translocating transhydrogenase leads to reversible dissociation of the active dimer into inactive monomers
regulation of protein arginine methyltransferase 8 (prmt8) activity by its n-terminal domain
osteocrin is a specific ligand of the natriuretic peptide clearance receptor that modulates bone growth
shp2e76k mutant confers cytokine-independent survival of tf-1 myeloid cells by up-regulating bcl-xl
the role of the n terminus and transmembrane domain of trpm8 in channel localization and tetramerization
molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer
stabilization of an immunoglobulin fold domain by an engineered disulfide bond at the buried hydrophobic region
a novel calmodulin-ca2+ target recognition activates the bcl-2 regulator fkbp38
three-dimensional structure of the ephb2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition
identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human udp-glucuronosyltransferases 1a
hemin interactions and alterations of the subcellular localization of prion protein
phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (enac) in cultured collecting duct cells
regulation of iron homeostasis mediated by the heme-binding protein dap1 (damage resistance protein 1) via the p450 protein erg11/cyp51
crystal structure of the non-heme iron dioxygenase ptlh in pentalenolactone biosynthesis
os-9 regulates the transit and polyubiquitination of trpv4 in the endoplasmic reticulum
connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through β-catenin-t-cell factor/lef signaling
a tunable ratchet driving human rna polymerase ii translocation adjusted by accurately templated nucleoside triphosphates loaded at downstream sites and by elongati..
transfer of monomeric endotoxin from md-2 to cd1
metabolism and elimination of the endogenous dna adduct, 3-(2-deoxy-β-d-erythropentofuranosyl)-pyrimido[1,2-]purine-10(3h)-one, in the rat
heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons
intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of alzheimer disease
proteolysis of the membrane type-1 matrix metalloproteinase prodomain
identification of a calmodulin-binding nac protein as a transcriptional repressor in arabidopsis
differential activities of glucocorticoid-induced leucine zipper protein isoforms
selection of genetically encoded fluorescent single domain antibodies engineered for efficient expression in escherichia coli
the caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia
selective incorporation of polyanionic molecules into hamster prions
tbc1d20 is a rab1 gtpase-activating protein that mediates hepatitis c virus replication
down-regulation of phosphoglucose isomerase/autocrine motility factor expression sensitizes human fibrosarcoma cells to oxidative stress leading to cellular senesce..
spatiotemporal expression of ameloblastin isoforms during murine tooth development
the molecular basis for inhibition of bphd, a c-c bond hydrolase involved in polychlorinated biphenyls degradation
daxx-like protein of drosophila interacts with dmp53 and affects longevity and ark mrna level
the essential cell division protein ftsn interacts with the murein (peptidoglycan) synthase pbp1b in escherichia coli
metal-catalyzed oxidation of the werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions
an auto-regulatory loop between stress sensors inrf2 and nrf2 controls their cellular abundance
structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in amp/fructose 2,6-bisphosphate inhibition
gain-of-function mutation in trpml3 causes the mouse varitint-waddler phenotype
a novel cpg-free vertebrate insulator silences the testis-specific sp-10 gene in somatic tissues
sumoylation-dependent control of homotypic and heterotypic synergy by the krüppel-type zinc finger protein zbp-89
the leader peptide of yeast atp6p is required for efficient interaction with the atp9p ring of the mitochondrial atpase
role for kap1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating kap1-mediated transcriptional repression
nramp-1 expression modulates protein-tyrosine phosphatase activity in macrophages
regulation of peroxiredoxins by nitric oxide in immunostimulated macrophages
twin arginine translocation (tat)-dependent export in the apparent absence of tatabc or tata complexes using modified escherichia coli tata subunits that substitute..
nherf1 regulates parathyroid hormone receptor membrane retention without affecting recycling
nod2 pathway activation by mdp or mycobacterium tuberculosis infection involves the stable polyubiquitination of rip2
critical role of the phosphatidylinositol 3-kinase/akt/glycogen synthase kinase-3β signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arres..
runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression
a constitutive, transient receptor potential-like ca2+ influx pathway in presynaptic nerve endings independent of voltage-gated ca2+ channels and na+/ca2+ exchange
rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/akt2 feedback signaling
critical and functional regulation of chop (c/ebp homologous protein) through the n-terminal portion
substrate-linked conformational change in the periplasmic component of a cu(i)/ag(i) efflux system
crystal structure of cel44a, a glycoside hydrolase family 44 endoglucanase from clostridium thermocellum
the adam10 prodomain is a specific inhibitor of adam10 proteolytic activity and inhibits cellular shedding events
internalization of β-amyloid peptide by primary neurons in the absence of apolipoprotein e
structural basis for the regulation of n-acetylglutamate kinase by pii in arabidopsis thaliana
butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase
genetic removal of tri-unsaturated fatty acids suppresses developmental and molecular phenotypes of an arabidopsis tocopherol-deficient mutant
continuous activation of gq in osteoblasts results in osteopenia through impaired osteoblast differentiation
lysosomal dysfunction results in altered energy balance
requirement of glycosylphosphatidylinositol anchor of cripto-1 for trans activity as a nodal co-receptor
structural basis of ubiquitin recognition by the ubiquitin-associated (uba) domain of the ubiquitin ligase edd
holo- and apo-bound structures of bacterial periplasmic heme-binding proteins
bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with rheb
sts1 can overcome the loss of rad23 and rpn10 and represents a novel regulator of the ubiquitin/proteasome pathway
chromatin opening and stable perturbation of core histone:dna contacts by foxo1
inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator
shear-induced disulfide bond formation regulates adhesion activity of von willebrand factor
the atpase cycle of the endoplasmic chaperone grp94
overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12
kinetics of the interactions between yeast elongation factors 1a and 1b, guanine nucleotides, and aminoacyl-trna
methylation of bacterial release factors rf1 and rf2 is required for normal translation termination in vivo
evolution of differences in transport function in slc11a family members
a role for atp-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion
specificity and mechanism of action of eht 1864, a novel small molecule inhibitor of rac family small gtpases
truncation of annexin a1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase a2 in normal and malignant squamous epithe..
tnfr1 and tnfr2 signaling interplay in cardiac myocytes
domain-swapped dimerization of the second pdz domain of zo2 may provide a structural basis for the polymerization of claudins
a weak lck tail bite is necessary for lck function in t cell antigen receptor signaling
old yellow enzymes, highly homologous fmn oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast
the intercalated disc protein, mxin, is capable of interacting with β-catenin and bundling actin filaments
crystal structures of yeast β-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements
p56lck tyrosine kinase enhances the assembly of death-inducing signaling complex during fas-mediated apoptosis
conformational variability of the glycine receptor m2 domain in response to activation by different agonists
differences in carbon isotope discrimination of three variants of d-ribulose-1,5-bisphosphate carboxylase/oxygenase reflect differences in their catalytic mechanisms
structural basis for innate immune sensing by m-ficolin and its control by a ph-dependent conformational switch
sequence elements in both subunits of the dna fragmentation factor are essential for its nuclear transport
structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein e
regulation of dopamine transporter function and cell surface expression by d3 dopamine receptors
influence of water, fat, and glycerol on the mechanism of thermal prion inactivation
fetuin a stabilizes m-calpain and facilitates plasma membrane repair
high titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of prpsc in vivo
decorin-transforming growth factor-β interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices
structure-function analysis of mouse purβ ii
sequential and synergistic modification of human rpa stimulates chromosomal dna repair
deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality
oxidative modification to cysteine sulfonic acid of cys111 in human copper-zinc superoxide dismutase
a small atpase protein of arabidopsis, tgd3, involved in chloroplast lipid import
crystal structure of the ech2 catalytic domain of curf from lyngbya majuscula
functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human ht-1080 fibrosarcoma exhi..
roles for two aminopeptidases in vacuolar hemoglobin catabolism in plasmodium falciparum
structure and mechanism of lysine-specific demethylase enzymes
intramolecular fluorescence resonance energy transfer between fused autofluorescent proteins reveals rearrangements of the n- and c-terminal segments of the plasma ..
activation of a c-terminal transcriptional activation domain of erk5 by autophosphorylation
histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression
tandem phosphorylation of ser-911 and thr-912 at the c terminus of yeast plasma membrane h+-atpase leads to glucose-dependent activation
transcription factor e is a part of transcription elongation complexes
spectroscopic and kinetic studies of y114f and w116f mutants of me2so reductase from rhodobacter capsulatus
the role of the fibronectin igd motif in stimulating fibroblast migration
calcium-activated (p)ppgpp synthetase in chloroplasts of land plants
pseudomonas fluorescens cha0 produces enantio-pyochelin, the optical antipode of the pseudomonas aeruginosa siderophore pyochelin
anticancer drugs up-regulate hspbp1 and thereby antagonize the prosurvival function of hsp70 in tumor cells
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