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camkii isoforms differentially affect calcium handling but similarly regulate hdac/mef2 transcriptional responses
aciniform spidroin, a constituent of egg case sacs and wrapping silk fibers from the black widow spider latrodectus hesperus
a peptide-gated ion channel from the freshwater polyp hydra
substitutions of potentially phosphorylatable serine residues of bax reveal how they may regulate its interaction with mitochondria
profiling the enzymatic properties and inhibition of human complement factor b
dynamics of the hypoxia-inducible factor-1-vascular endothelial growth factor promoter complex
probing the structure of the dimeric ktrb membrane protein
different roles of - and β-branch xanthophylls in photosystem assembly and photoprotection
low utilization of circulating glucose after food withdrawal in snell dwarf mice
pivotal involvement of fc receptor iia in the neutralization of lipopolysaccharide signaling via a potent novel anti-tlr4 monoclonal antibody 15c1
early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model
dyrk1a-mediated hyperphosphorylation of tau
a phosphomimetic mutation in the sall1 repression motif disrupts recruitment of the nucleosome remodeling and deacetylase complex and repression of gbx2
the c-terminal extension of the β7 subunit and activator complexes stabilize nascent 20 s proteasomes and promote their maturation
cryptosporidium p30, a galactose/n-acetylgalactosamine-specific lectin, mediates infection in vitro
plexin-b1 utilizes rhoa and rho kinase to promote the integrin-dependent activation of akt and erk and endothelial cell motility
β-galactoside 2,6-sialyltransferase i cleavage by bace1 enhances the sialylation of soluble glycoproteins
crystal structure of nucleoporin nic96 reveals a novel, intricate helical domain architecture
the serine protease domain of hepatitis c viral ns3 activates rna helicase activity by promoting the binding of rna substrate
observations on the calcium dependence and reversibility of cobalamin transport across the outer membrane of escherichia coli
myc down-regulation as a mechanism to activate the rb pathway in stat5a-induced senescence
pax-6 and c-maf functionally interact with the -cell-specific dna element g1 in vivo to promote glucagon gene expression
removal of fkbp12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias
a peptide derived from tenascin-c induces β1 integrin activation through syndecan-4
diversity of penicillin-binding proteins
in vitro reconstitution of the modulation of drosophila notch-ligand binding by fringe
cd4 interacts constitutively with multiple ccr5 at the plasma membrane of living cells
evidence for physical interaction between the immunoglobulin heavy chain variable region and the 3‘ regulatory region
crystal structure of an unusual thioredoxin protein with a zinc finger domain
neuronal glutamate transporters vary in substrate transport rate but not in unitary anion channel conductance
prostaglandin e2 activates hpk1 kinase activity via a pka-dependent pathway
mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells
the cyclophilin-like domain of ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis
functional smpb-ribosome interactions require tmrna
regulation of nox1 activity via protein kinase a-mediated phosphorylation of noxa1 and 14-3-3 binding
microtubule motors regulate isoc activation necessary to increase endothelial cell permeability
structural analysis of the bacterial hpr kinase/phosphorylase v267f mutant gives insights into the allosteric regulation mechanism of this bifunctional enzyme
stat3 isoforms, and β, demonstrate distinct intracellular dynamics with prolonged nuclear retention of stat3β mapping to its unique c-terminal end
allosteric small molecules unveil a role of an extracellular e2/transmembrane helix 7 junction for g protein-coupled receptor activation
role of hypusinated eukaryotic translation initiation factor 5a in polyamine depletion-induced cytostasis
identification of dioxygenases required for aspergillus development
evidence for the direct involvement of the proteasome in the proteolytic processing of the aspergillus nidulans zinc finger transcription factor pacc
quantification and modeling of tripartite cd2-, cd58fc chimera (alefacept)-, and cd16-mediated cell adhesion
a smooth muscle cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine
a charge reversal differentiates (p)ppgpp synthesis by monofunctional and bifunctional rel proteins
the pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous akt/pkb activity
p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis
hctr9, a component of paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of stat3-dna interactions
plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols
identification of the calmodulin binding domain of connexin 43
the mitotic regulator survivin binds as a monomer to its functional interactor borealin
specific inhibition of autoimmune t cell transmigration contributes to cell functionality and insulin synthesis in non-obese diabetic (nod) mice
cell shape-dependent control of ca2+ influx and cell cycle progression in swiss 3t3 fibroblasts
characterization of pancreatic transcription factor pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy
mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homol..
regulation of arrestin binding by rhodopsin phosphorylation level
apobec3g inhibits dna strand transfer during hiv-1 reverse transcription
the dna damage response mediator mdc1 directly interacts with the anaphase-promoting complex/cyclosome
suppressor mutations in the transmembrane segments of p-glycoprotein promote maturation of processing mutants and disrupt a subset of drug-binding sites
the role of inositol acylation and inositol deacylation in the toxoplasma gondii glycosylphosphatidylinositol biosynthetic pathway
mlh1- and atm-dependent mapk signaling is activated through c-abl in response to the alkylator n-methyl-n‘-nitro-n‘-nitrosoguanidine
laser excitation studies of the product release steps in the catalytic cycle of the light-driven enzyme, protochlorophyllide oxidoreductase
human collagen krox up-regulates type i collagen expression in normal and scleroderma fibroblasts through interaction with sp1 and sp3 transcription factors
fidelity and processivity of reverse transcription by the human mitochondrial dna polymerase
involvement of the mitogen-activated protein kinase c-jun nh2-terminal kinase 1 in thrombus formation
activation gating of herg potassium channels
analysis of glycan polymers produced by peptidoglycan glycosyltransferases
androgen receptor regulation of the versican gene through an androgen response element in the proximal promoter
stimulation of c-myc transcriptional activity by virf-3 of kaposi sarcoma-associated herpesvirus
peptides selected for the protein nanocage pores change the rate of iron recovery from the ferritin mineral
myeloperoxidase inactivates timp-1 by oxidizing its n-terminal cysteine residue
glucose regulates diacylglycerol intracellular levels and protein kinase c activity by modulating diacylglycerol kinase subcellular localization
molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the -d-phosphohexomutase family
activation profiles and regulatory cascades of the human kallikrein-related peptidases
growth factors of lower vertebrates
a novel tyrosine phosphorylation site in protein kinase d contributes to oxidative stress-mediated activation
novel role for the liver x nuclear receptor in the suppression of lung inflammatory responses
a novel allosteric pathway of thrombin inhibition
role of mapk phosphatase-1 in sustained activation of jnk during ethanol-induced apoptosis in hepatocyte-like vl-17a cells
sufr coordinates two [4fe-4s]2+, 1+ clusters and functions as a transcriptional repressor of the sufbcds operon and an autoregulator of sufr in cyanobacteria
role of the asymmetry of the homodimeric b2 stator stalk in the interaction with the f1 sector of escherichia coli atp synthase
cadmium trapping in an epithelial sodium channel pore mutant
interplay between cernunnos-xlf and nonhomologous end-joining proteins at dna ends in the cell
stress-induced c-jun activation mediated by polo-like kinase 3 in corneal epithelial cells
structural elements necessary for oligomerization, trafficking, and cell sorting function of paraxial protocadherin
the role of self-association in fin1 function on the mitotic spindle
identification of the mxih needle protein residues responsible for anchoring invasion plasmid antigen d to the type iii secretion needle tip
mediator subunit med28 (magicin) is a repressor of smooth muscle cell differentiation
functional gene screening system identified trpv4 as a regulator of chondrogenic differentiation
membrane targeting of ribosomes and their release require distinct and separable functions of ftsy
escherichia coli signal recognition particle receptor ftsy contains an essential and autonomous membrane-binding amphipathic helix
mechanisms for asporin function and regulation in articular cartilage
expression and regulation of the osteoarthritis-associated protein asporin
human b-lymphocytes express 2-6-sialylated 6-sulfo-n-acetyllactosamine serving as a preferred ligand for cd22/siglec-2
regulation of irf-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus
myelin basic protein-primed t cells induce neurotrophins in glial cells via 53 integrin
the n terminus of the anti-apoptotic bcl-2 homologue mcl-1 regulates its localization and function
the mre11/rad50/nbs1 complex plays an important role in the prevention of dna rereplication in mammalian cells
conformational analysis of epac activation using amide hydrogen/deuterium exchange mass spectrometry
epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of -secretase
critical role of helix 4 of hiv-1 capsid c-terminal domain in interactions with human lysyl-trna synthetase
the interaction of akt with appl1 is required for insulin-stimulated glut4 translocation
a protein kinase c-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of bcl-2
mycobacterial cells have dual nickel-cobalt sensors
signal responsiveness of ib kinases is determined by cdc37-assisted transient interaction with hsp90
dual role for zn2+ in maintaining structural integrity and inducing dna sequence specificity in a promiscuous endonuclease
nucleocytoplasmic shuttling of the zinc finger protein ezi is mediated by importin-7-dependent nuclear import and crm1-independent export mechanisms
bacteria-derived peptidoglycans constitute pathogen-associated molecular patterns triggering innate immunity in arabidopsis
structural insight into the interaction between platelet integrin iib3 and cytoskeletal protein skelemin
the exchangeable apolipoprotein apoc-i promotes membrane fusion of hepatitis c virus
atp-dependent assembly of the human origin recognition complex
mapping the binding site on small ankyrin 1 for obscurin
characterization of the amino acids from neisseria meningitidis methionine sulfoxide reductase b involved in the chemical catalysis and substrate specificity of the..
a covalent inhibitor targeting an intermediate conformation of the fusogenic subunit of the hiv-1 envelope complex
isolation of the schizosaccharomyces pombe proteasome subunit rpn7 and a structure-function study of the proteasome-cop9-initiation factor domain
interaction of the adipocyte fatty acid-binding protein with the hormone-sensitive lipase
a triplex-forming sequence from the human c-myc promoter interferes with dna transcription
the involvement of abl and ptp61f in the regulation of abi protein localization and stability and lamella formation in drosophila s2 cells
dynamic receptor-dependent activation of inducible nitric-oxide synthase by erk-mediated phosphorylation of ser745
the sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells
functional analysis of transmembrane domain 2 of the m1 muscarinic acetylcholine receptor
a caspase-3-cleaved fragment of the glial glutamate transporter eaat2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant sod1-linked amyo..
modulation of nfb activity and e-cadherin by the type iii transforming growth factor receptor regulates cell growth and motility
overexpression of a zn2+-sensitive soluble exopolyphosphatase from trypanosoma cruzi depletes polyphosphate and affects osmoregulation
nucleosomal core histones mediate dynamic regulation of poly(adp-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity
the slingshot family of phosphatases mediates rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes
defining the mechanism of activation of amp-activated protein kinase by the small molecule a-769662, a member of the thienopyridone family
mechanism of action of a-769662, a valuable tool for activation of amp-activated protein kinase
thrombomodulin is a clock-controlled gene in vascular endothelial cells
further evidence for two functional forms of prothrombinase each specific for either of the two prothrombin activation cleavages
micro rna 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells
selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine trnas lacking um34
mdm2 chaperones the p53 tumor suppressor
wnk1 is a novel regulator of munc18c-syntaxin 4 complex formation in soluble nsf attachment protein receptor (snare)-mediated vesicle exocytosis
oxidation of 2-cys-peroxiredoxins by arachidonic acid peroxide metabolites of lipoxygenases and cyclooxygenase-2
mutational analysis of the ribosomal protein rpl10 from yeast
mitochondrial complex ii in the post-ischemic heart
accumulation of glucosylceramide in murine testis, caused by inhibition of -glucosidase
the hsp110 molecular chaperone stabilizes apolipoprotein b from endoplasmic reticulum-associated degradation (erad)
involvement of prostaglandin e2 in production of amyloid- peptides both in vitro and in vivo
activation of nonreceptor tyrosine kinase bmx/etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and erbb3 in prostate cancer cells
platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mrna in rat smooth muscle cells requires the c-src family of protein-tyrosine kinases
temperature-dependent modulation of cav3 t-type calcium channels by protein kinases c and a in mammalian cells
epinephrine regulation of the endothelial nitric-oxide synthase
the pestivirus glycoprotein erns is anchored in plane in the membrane via an amphipathic helix
phospholemman transmembrane structure reveals potential interactions with na+/k+-atpase
cyclic nucleotide phosphodiesterase pde1c1 in human cardiac myocytes
neural adrenergic/cyclic amp regulation of the immunoglobulin e receptor -subunit expression in the mammalian pinealocyte
anti-hepatitis c virus activity of tamoxifen reveals the functional association of estrogen receptor with viral rna polymerase ns5b
p68 rna helicase unwinds the human let-7 microrna precursor duplex and is required for let-7-directed silencing of gene expression
inhibition of skeletal muscle clc-1 chloride channels by low intracellular ph and atp
retinoschisin (rs1), the protein encoded by the x-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its inter..
contribution of ext1, ext2, and extl3 to heparan sulfate chain elongation
site-specific binding affinities within the h2b tail domain indicate specific effects of lysine acetylation
equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the mek/erk/p90rsk/activator protein-1 pathway
overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (gtp) in skeletal muscle repatterns energy metabolism in the mouse
fluorescence resonance energy transfer analysis of secretin docking to its receptor
mitochondrial swelling impairs the transport of organelles in cerebellar granule neurons
three binding sites for stalk protein dimers are generally present in ribosomes from archaeal organism
conditional intestinal lipotoxicity in apobec-1-/- mttp-iko mice
developmental pluripotency-associated 4 (dppa4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage
activated protein c mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-depend..
alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization
activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement
granzyme b-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells
role of inositol 1,4,5-trisphosphate receptors in apoptosis in dt40 lymphocytes
restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase
epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation
structural basis of glyphosate tolerance resulting from mutations of pro101 in escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase
sorla/lr11 regulates processing of amyloid precursor protein via interaction with adaptors gga and pacs-1
survival in the presence of antifungals
critical role of desolvation in the binding of 20-hydroxyecdysone to the ecdysone receptor
oligomerization and transglutaminase cross-linking of the cystatin cres in the mouse epididymal lumen
a multifunctional rna recognition motif in poly(a)-specific ribonuclease with cap and poly(a) binding properties
juxtacrine activation of epidermal growth factor (egf) receptor by membrane-anchored heparin-binding egf-like growth factor protects epithelial cells from anoikis w..
functional interaction of neuronal cav1.3 l-type calcium channel with ryanodine receptor type 2 in the rat hippocampus
glycogen synthase kinase-3 reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases
activity-dependent regulation of h channel distribution in hippocampal ca1 pyramidal neurons
myrip anchors protein kinase a to the exocyst complex
the dodecin from thermus thermophilus, a bifunctional cofactor storage protein
the pdz domain-binding motif of the human t cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hscrib in t cells
structural and thermodynamic bases for the design of pure prolactin receptor antagonists
crystal structure of the oxygenase component (hpab) of the 4-hydroxyphenylacetate 3-monooxygenase from thermus thermophilus hb8
parathyroid hormone stimulates osteoblastic expression of mcp-1 to recruit and increase the fusion of pre/osteoclasts
determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis
glycosaminoglycans facilitate procathepsin b activation through disruption of propeptide-mature enzyme interactions
unique hydrophobic extension of the rgs2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other rgs r4/b subfamily members
protein kinase c regulates -aminobutyrate type a receptor sensitivity to ethanol and benzodiazepines through phosphorylation of 2 subunits
slya and h-ns regulate transcription of the escherichia coli k5 capsule gene cluster, and expression of slya in escherichia coli is temperature-dependent, positivel..
fe65 stimulates proteolytic liberation of the -amyloid precursor protein intracellular domain
soluble a inhibits specific signal transduction cascades common to the insulin receptor pathway
pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood
identification of a novel inhibitor of differentiation-1 (id-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apo..
the flagellar sigma factor flia regulates adhesion and invasion of crohn disease-associated escherichia coli via a cyclic dimeric gmp-dependent pathway
reduced pepsin a processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation
curculin exhibits sweet-tasting and taste-modifying activities through its distinct molecular surfaces
functional tat transport of unstructured, small, hydrophilic proteins
correctors promote maturation of cystic fibrosis transmembrane conductance regulator (cftr)-processing mutants by binding to the protein
crystallographic studies of human mitoneet
differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin
heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor
proteomic and lipid characterization of apolipoprotein b-free luminal lipid droplets from mouse liver microsomes
mutations in the sec61p channel affecting signal sequence recognition and membrane protein topology
a muscle-specific promoter directs pitx3 gene expression in skeletal muscle cells
retinoic acid receptor isotype specificity in f9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic acid response elem..
class a scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase a2 and 12/15-lipoxygenase to rac and cdc42 activation
heat shock factor 1 attenuates 4-hydroxynonenal-mediated apoptosis
chemical knockdown of protein-tyrosine phosphatase 1b by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth fact..
secretory leucocyte protease inhibitor inhibits interferon--induced cathepsin s expression
secretion and assembly of type iv and vi collagens depend on glycosylation of hydroxylysines
a cysteine-rich lim-only protein mediates regulation of smooth muscle-specific gene expression by cgmp-dependent protein kinase
spermidine/spermine n1-acetyltransferase-1 binds to hypoxia-inducible factor-1 (hif-1) and rack1 and promotes ubiquitination and degradation of hif-1
intestinal monoacylglycerol metabolism
critical dna binding interactions of the insulator protein ctcf
mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin
the lim domains of wlim1 define a new class of actin bundling modules
phenoloxidase is an important component of the defense against aeromonas hydrophila infection in a crustacean, pacifastacus leniusculus
regulation of insulin secretion by sirt4, a mitochondrial adp-ribosyltransferase
kinetic mechanism of human dutpase, an essential nucleotide pyrophosphatase enzyme
nad kinase levels control the nadph concentration in human cells
cmo1 deficiency abolishes vitamin a production from -carotene and alters lipid metabolism in mice
a cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites
effect of line tension on the lateral organization of lipid membranes
dynamin is functionally coupled to insulin granule exocytosis
a novel role of the interferon-inducible protein ifi16 as inducer of proinflammatory molecules in endothelial cells
a new role of thrombopoietin enhancing ex vivo expansion of endothelial precursor cells derived from ac133-positive cells
calmodulin binds and stabilizes the regulatory enzyme, ctp:phosphocholine cytidylyltransferase
elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (hsd) and identification of all enzyme forms on the reaction coordinate
epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal within the carboxyl cytoplasmic domain of the subunit
udp-glucuronosyltransferase 2b15 (ugt2b15) and ugt2b17 enzymes are major determinants of the androgen response in prostate cancer lncap cells
wobble inosine trna modification is essential to cell cycle progression in g1/s and g2/m transitions in fission yeast
an iron-sulfur cluster in the c-terminal domain of the p58 subunit of human dna primase
effect of high concentration of inert cosolutes on the refolding of an enzyme
irak-2 participates in multiple toll-like receptor signaling pathways to nfb via activation of traf6 ubiquitination
the high mobility group box transcription factor nhp6ap enters the nucleus by a calmodulin-dependent, ran-independent pathway
dynamic interaction between src and c-terminal src kinase in integrin iib3-mediated signaling to the cytoskeleton
derepression of microrna-mediated protein translation inhibition by apolipoprotein b mrna-editing enzyme catalytic polypeptide-like 3g (apobec3g) and its family mem..
pii is important in regulation of nitrogen metabolism but not required for heterocyst formation in the cyanobacterium anabaena sp. pcc 7120
protein stability and transcription factor complex assembly determined by the scl-lmo2 interaction
a global transcriptional regulator in thermococcus kodakaraensis controls the expression levels of both glycolytic and gluconeogenic enzyme-encoding genes
inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor lyve-1
molecular basis distinguishing the dna binding profile of nrf2-maf heterodimer from that of maf homodimer
specific sites in the cytoplasmic n terminus modulate conformational transitions of the na,k-atpase
nuclear factor-b p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis
roles of active site residues and the huh motif of the f plasmid trai relaxase
hypoxia-inducible factor mediates hypoxic and tumor necrosis factor -induced increases in tumor necrosis factor- converting enzyme/adam17 expression by synovial cells
n-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration
stimulus-induced phosphorylation of vacuolar h+-atpase by protein kinase a
the histone deacetylase hdac4 connects neural activity to muscle transcriptional reprogramming
generation of an analog-sensitive syk tyrosine kinase for the study of signaling dynamics from the b cell antigen receptor
direct binding of the dynamin-like gtpase, dnm1, to mitochondrial dynamics protein fis1 is negatively regulated by the fis1 n-terminal arm
amplitude control of protein kinase c by rinck, a novel e3 ubiquitin ligase
fluidity of structure and swiveling of helices in the subunit c ring of escherichia coli atp synthase as revealed by cysteine-cysteine cross-linking
differences in the single-stranded dna binding activities of mcm2-7 and mcm46
development of peptide mimics of a protective epitope of vibrio cholerae ogawa o-antigen and investigation of the structural basis of peptide mimicry
nkcc2 surface expression in mammalian cells
hydrophobic regions adjacent to transmembrane domains 1 and 5 are important for the targeting of the 70-kda peroxisomal membrane protein
two sca (stigma/style cysteine-rich adhesin) isoforms show structural differences that correlate with their levels of in vitro pollen tube adhesion activity
structure-function analysis of the endoplasmic reticulum oxidoreductase tmx3 reveals interdomain stabilization of the n-terminal redox-active domain
potentiation of trpc5 by protons
phosphorylation of pdz1 domain attenuates nherf-1 binding to cellular targets
caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic bcl-2 family members
injection of flagellin into the host cell cytosol by salmonella enterica serotype typhimurium
hsf1-tpr interaction facilitates export of stress-induced hsp70 mrna
identification of svip as an endogenous inhibitor of endoplasmic reticulum-associated degradation
the role of thrombin exosites i and ii in the activation of human coagulation factor v
nad kinases use substrate-assisted catalysis for specific recognition of nad
the interplay between components of the mitochondrial protein translocation motor studied using purified components
the deubiquitinating enzyme usp11 controls an ib kinase (ikk)-p53 signaling pathway in response to tumor necrosis factor (tnf)
dual effect of acid ph on purinergic p2x3 receptors depends on the histidine 206 residue
endotoxin priming of neutrophils requires nadph oxidase-generated oxidants and is regulated by the anion transporter clc-3
molecular determinants of binding between gly-leu-phe-gly nucleoporins and the nuclear pore complex
functional characterization of the atypical hsp70 subunit of yeast ribosome-associated complex
active -secretase complexes contain only one of each component
krüppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation
3-ketosteroid reductase activity and expression by fetal rat osteoblasts
identification of a biosynthetic gene cluster in rice for momilactones
specificity of g signaling to kir3 channels depends on the helical domain of pertussis toxin-sensitive g subunits
a multiprotein complex that mediates translational enhancement in drosophila
a yeast model of the neurogenic ataxia retinitis pigmentosa (narp) t8993g mutation in the mitochondrial atp synthase-6 gene
modulation of epithelial sodium channel trafficking and function by sodium 4-phenylbutyrate in human nasal epithelial cells
arrangement of subunits in the proteolipid ring of the v-atpase
sirt1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription
thermosensing coordinates a cis-regulatory module for transcriptional activation of the intracellular virulence system in salmonella enterica serovar typhimurium
requirement of phospholipase d for ilimaquinone-induced golgi membrane fragmentation
lyase activities of cpcs- and cpct-like proteins from nostoc pcc7120 and sequential reconstitution of binding sites of phycoerythrocyanin and phycocyanin -subunits
fscb, a novel protein kinase a-phosphorylated calcium-binding protein, is a cabyr-binding partner involved in late steps of fibrous sheath biogenesis
the chec phosphatase regulates chemotactic adaptation through ched
activation of the sspa serine protease zymogen of staphylococcus aureus proceeds through unique variations of a trypsinogen-like mechanism and is dependent on both ..
leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling
the confluence-dependent interaction of cytosolic phospholipase a2- with annexin a1 regulates endothelial cell prostaglandin e2 generation
a novel interaction between procaspase 8 and sparc enhances apoptosis and potentiates chemotherapy sensitivity in colorectal cancers
activity-dependent neuroprotective protein constitutes a novel element in the swi/snf chromatin remodeling complex
critical role of glu40-ser48 loop linking actuator domain and first transmembrane helix of ca2+-atpase in ca2+ deocclusion and release from adp-insensitive phosphoe..
very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization
caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse
the phage t4 protein uvsw drives holliday junction branch migration
participation of the chaperone hsc70 in the trafficking and functional expression of asic2 in glioma cells
crystallographic and nmr analyses of uvsw and uvsw.1 from bacteriophage t4
recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2
bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, -globin, and nadp(h..
the direct involvement of sirt1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
comparison of intra-organellar chaperone capacity for dealing with stress-induced protein unfolding
convergent evolution of a new arsenic binding site in the arsr/smtb family of metalloregulators
resistin is a key mediator of glucose-dependent insulinotropic polypeptide (gip) stimulation of lipoprotein lipase (lpl) activity in adipocytes
structural and functional characterization of the interaction between cyclophilin b and a heparin-derived oligosaccharide
10-formyltetrahydrofolate dehydrogenase requires a 4‘-phosphopantetheine prosthetic group for catalysis
ubiquitin-dependent proteolytic control of sumo conjugates
the yeast hex3·slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation
metabolic engineering for betaine accumulation in microbes and plants
wiskott-aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages
probing the role of prp repeats in conformational conversion and amyloid assembly of chimeric yeast prions
fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage
succination of protein thiols during adipocyte maturation
mcm forked substrate specificity involves dynamic interaction with the 5‘-tail
dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during 2-adrenoceptor and prostanoid receptor camp signaling
proteasomes control caspase-1 activation in anthrax lethal toxin-mediated cell killing
mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin v3 and stablization of pinc..
myopathy-associated b-crystallin mutants
lpt1 encodes a membrane-bound o-acyltransferase involved in the acylation of lysophospholipids in the yeast saccharomyces cerevisiae
vopa inhibits atp binding by acetylating the catalytic loop of mapk kinases
mechanism of proton transfer in the 3-hydroxysteroid dehydrogenase/carbonyl reductase from comamonas testosteroni
keg1/yfr042w encodes a novel kre6-binding endoplasmic reticulum membrane protein responsible for -1,6-glucan synthesis in saccharomyces cerevisiae
structural requirements for the bard1 tumor suppressor in chromosomal stability and homology-directed dna repair
quail sulf1 function requires asparagine-linked glycosylation
production and characterization of rna aptamers specific for amyloid fibril epitopes
the g12/13 family of heterotrimeric g proteins and the small gtpase rhoa link the kaposi sarcoma-associated herpes virus g protein-coupled receptor to heme oxygenas..
the role of brain-derived neurotrophic factor (bdnf)-induced xbp1 splicing during brain development
the krüppel-associated box repressor domain can trigger de novo promoter methylation during mouse early embryogenesis
atrial natriuretic peptide attenuates elevations in ca2+ and protects hepatocytes by stimulating net plasma membrane ca2+ efflux
conformation-specific binding of -synuclein to novel protein partners detected by phage display and nmr spectroscopy
inhibition of human dimethylarginine dimethylaminohydrolase-1 by s-nitroso-l-homocysteine and hydrogen peroxide
transforming growth factor-β regulates dna binding activity of transcription factor fli1 by p300/creb-binding protein-associated factor-dependent acetylation
chemical genetics define the roles of p38 and p38β in acute and chronic inflammation
altered rna binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2
dna branch nuclease activity of vaccinia a22 resolvase
structural and functional characterization of recombinant matrilin-3 a-domain and implications for human genetic bone diseases
mechanism of transcriptional activation by the proto-oncogene twist1
genetic ablation of calcium-independent phospholipase a2 leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial ..
il-21 is produced by th17 cells and drives il-17 production in a stat3-dependent manner
integrin-linked kinase regulates n-wasp-mediated actin polymerization and tension development in tracheal smooth muscle
identification of human t cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein
elevated expression of cyr61 enhances peritoneal dissemination of gastric cancer cells through integrin 21
enhanced formation of a transport metabolon in exocrine cells of nhe1–/– mice
tumor necrosis factor- augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-β-activated kin..
swi/snf chromatin remodeling atpase brm regulates the differentiation of early retinal stem cells/progenitors by influencing brn3b expression and notch signaling
activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses
proper perinuclear localization of the trim-like protein myospryn requires its binding partner desmin
unraveling tissue regeneration pathways using chemical genetics
clostridium difficile glucosyltransferase toxin b-essential amino acids for substrate binding
two related but distinct chondroitin sulfate mimetope octasaccharide sequences recognized by monoclonal antibody wf6
cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class i-like glycoprotein, m153
a subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and jnk-dependent pathways
nm23-h1 tumor suppressor and its interacting partner strap activate p53 function
akap13, a rhoa gtpase-specific guanine exchange factor, is a novel regulator of tlr2 signaling
conditional disruption of calcineurin b1 in osteoblasts increases bone formation and reduces bone resorption
a family 2 pectate lyase displays a rare fold and transition metal-assisted β-elimination
the a-chain of insulin contacts the insert domain of the insulin receptor
the interaction of mpar3 with the ubiquitin ligase smurf2 is required for the establishment of neuronal polarity
molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase
amyloid β-protein precursor juxtamembrane domain regulates specificity of -secretase-dependent cleavages
lateral compartmentalization of t cell receptor versus cd45 by galectin-n-glycan binding and microfilaments coordinate basal and activation signaling
dimerization of hsp90 is required for in vivo function
nadph oxidase activity selectively modulates vascular endothelial growth factor signaling pathways
role of the diacylglycerol kinase -conserved domains in membrane targeting in intact t cells
protein-tyrosine phosphatase h1 controls growth hormone receptor signaling and systemic growth
mcph1 functions in an h2ax-dependent but mdc1-independent pathway in response to dna damage
plasminogen structural domains exhibit different functions when associated with cell surface grp78 or the voltage-dependent anion channel
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