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a novel interaction between atrophin-interacting protein 4 and -p21-activated kinase-interactive exchange factor is mediated by an sh3 domain
enhanced lysosomal pathology caused by -synuclein mutants linked to dementia with lewy bodies
differential gene expression and subcellular targeting of arabidopsis glutathione s-transferase f8 is achieved through alternative transcription start sites
a cellular micro-rna, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against cryptosporidium parvum infection
sorting nexin 9 interacts with dynamin 1 and n-wasp and coordinates synaptic vesicle endocytosis
translation elongation factor eef1a2 is essential for post-weaning survival in mice
tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by bcl-2 proteins
binding and activation of dna topoisomerase iii by the rmi1 subunit
mitogen-activated protein kinase p38 regulates the wnt/cyclic gmp/ca2+ non-canonical pathway
mammalian notch-1 activates 1 integrins via the small gtpase r-ras
analysis of p element transposase protein-dna interactions during the early stages of transposition
plastidic phosphatidic acid phosphatases identified in a distinct subfamily of lipid phosphate phosphatases with prokaryotic origin
the clc-3 chloride transport protein traffics through the plasma membrane via interaction of an n-terminal dileucine cluster with clathrin
specificity and autoregulation of notch binding by tandem ww domains in suppressor of deltex
phosphatase activity, trimerization, and the c-terminal polybasic region are all required for prl1-mediated cell growth and migration
crystal structures of complexes of n-butyl- and n-nonyl-deoxynojirimycin bound to acid -glucosidase
slp-65 signal transduction requires src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of syk
chemoenzymatic synthesis with distinct pasteurella heparosan synthases
potentiation of ici182,780 (fulvestrant)-induced estrogen receptor- degradation by the estrogen receptor-related receptor- inverse agonist xct790
bcl3 acts as a negative regulator of transcription from the human t-cell leukemia virus type 1 long terminal repeat through interactions with torc3
identification and characterization of the major lysophosphatidylethanolamine acyltransferase in saccharomyces cerevisiae
factor va residues 311–325 represent an activated protein c binding region
the cdp-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species
functional anatomy of the drosophila microrna-generating enzyme
glutamine phosphoribosylpyrophosphate amidotransferase-independent phosphoribosyl amine synthesis from ribose 5-phosphate and glutamine or asparagine
modulation of apolipoprotein a-iv lipid binding by an interaction between the n and c termini
several dual specificity phosphatases coordinate to control the magnitude and duration of jnk activation in signaling response to oxidative stress
histone deacetylase inhibitors suppress tf-b-dependent agonist-driven tissue factor expression in endothelial cells and monocytes
allosteric coupling of two different functional active sites in monomeric plasmodium falciparum glyoxalase i
single molecule kinetic analysis of actin filament capping
effects of dietary calorie restriction or exercise on the pi3k and ras signaling pathways in the skin of mice
the rad9-hus1-rad1 checkpoint clamp regulates interaction of topbp1 with atr
molecular mapping and functional characterization of the vegf164 heparin-binding domain
a major fraction of fibronectin present in the extracellular matrix of tissues is plasma-derived
atrial glutathione content, calcium current, and contractility
transcriptional regulation of aqp-8, a caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the pou homeobox transcription factor ceh-6
disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant sod1
structural basis of enantioselective inhibition of cyclooxygenase-1 by s--substituted indomethacin ethanolamides
a dynamic loop at the active center of the escherichia coli pyruvate dehydrogenase complex e1 component modulates substrate utilization and chemical communication w..
integration of inositol phosphate signaling pathways via human itpk1
trehalulose synthase native and carbohydrate complexed structures provide insights into sucrose isomerization
junctional adhesion molecule-a is critical for the formation of pseudocanaliculi and modulates e-cadherin expression in hepatic cells
small heat shock protein a-crystallin regulates epithelial sodium channel expression
a critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15
a novel function of syndecan-2, suppression of matrix metalloproteinase-2 activation, which causes suppression of metastasis
tripeptides of rs1 (rsc1a1) inhibit a monosaccharide-dependent exocytotic pathway of na+-d-glucose cotransporter sglt1 with high affinity
transfer of the molybdenum cofactor synthesized by rhodobacter capsulatus moea to xdhc and moba
chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism
tumor-derived mutations in the trail receptor dr5 inhibit trail signaling through the dr4 receptor by competing for ligand binding
arabidopsis mutants lacking long chain base phosphate lyase are fumonisin-sensitive and accumulate trihydroxy-18:1 long chain base phosphate
activation of the cytochrome cd1 nitrite reductase from paracoccus pantotrophus
centromere pairing by a plasmid-encoded type i parb protein
the role of phosphoinositide 3-kinase c2 in insulin signaling
mecp2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing rett syndrome
structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin vip36
binding studies of -galnac-specific lectins to the -galnac (tn-antigen) form of porcine submaxillary mucin and its smaller fragments
(ndrg2) stimulates amiloride-sensitive na+ currents in xenopus laevis oocytes and fisher rat thyroid cells
erk1/2-p90rsk-mediated phosphorylation of na+/h+ exchanger isoform
regulation of microtubule assembly and stability by the transactivator of transcription protein of jembrana disease virus
the n1317h substitution associated with leber congenital amaurosis results in impaired interdomain packing in human crb1 epidermal growth factor-like (egf) domains
heme coordination by staphylococcus aureus isde
the cxxc motif is more than a redox rheostat
interactions between conserved domains within homodimers in the big1, big2, and gbf1 arf guanine nucleotide exchange factors
aeromonas exoenzyme t of aeromonas salmonicida is a bifunctional protein that targets the host cytoskeleton
the de novo synthesis of gdp-fucose is essential for flagellar adhesion and cell growth in trypanosoma brucei
breast cancer cell proliferation is inhibited by bad
structural basis for regulation of protein phosphatase 1 by inhibitor-2
a pre-equilibrium before nucleotide binding limits fingers subdomain closure by klentaq1
plasma membrane targeting is essential for rem-mediated ca2+ channel inhibition
chip chaperones wild type p53 tumor suppressor protein
ca2+-binding and ca2+-independent respiratory nadh and nadph dehydrogenases of arabidopsis thaliana
chronic ethanol and triglyceride turnover in white adipose tissue in rats
stimulation of neil2-mediated oxidized base excision repair via yb-1 interaction during oxidative stress
discovery of the true peroxy intermediate in the catalytic cycle of terminal oxidases by real-time measurement
retinoic acid receptor silences human papillomavirus-18 oncogene expression by induction of de novo methylation and heterochromatinization of the viral control region
polyamine-dependent regulation of spermidine-spermine n1-acetyltransferase mrna translation
c4b-binding protein and factor h compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack
tumor necrosis factor receptor-1 can function through a gq/11--arrestin-1 signaling complex
oxygen metabolism by endothelial nitric-oxide synthase
commonality and biosynthesis of the o-methyl phosphoramidate capsule modification in campylobacter jejuni
carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in pc12 cells via activation of phosp..
acetylation of lysine 56 of histone h3 catalyzed by rtt109 and regulated by asf1 is required for replisome integrity
microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein b-containing lipoprotein assembly in mca-rh7777 cells
ef24 induces g2/m arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing pten expression
the metalloreductase fre6p in fe-efflux from the yeast vacuole
identification of acidic amino acid residues in the protein kinase c v5 domain that contribute to its insensitivity to diacylglycerol
polarity of response to transforming growth factor-1 in proximal tubular epithelial cells is regulated by -catenin
identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin iib3 adhesive function in platelets
transcriptional specificity of drosophila dysfusion and the control of tracheal fusion cell gene expression
dynamic integration of -adrenergic and cholinergic signals in the atria
anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase / signaling pathway
sap97 directs the localization of kv4.2 to spines in hippocampal neurons
role of p38 map kinase and transforming growth factor- signaling in transepithelial migration of invasive bacterial pathogens
potent inhibition of hiv-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization
heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking
crystal structures of hydrophobin hfbii in the presence of detergent implicate the formation of fibrils and monolayer films
novel heme-based oxygen sensor with a revealing evolutionary history
htra2 regulates -amyloid precursor protein (app) metabolism through endoplasmic reticulum-associated degradation
specific targeting to murine myeloma cells of cyt1aa toxin from bacillus thuringiensis subspecies israelensis
ligand binding to cytochrome p450 3a4 in phospholipid bilayer nanodiscs
exocytotic release of atp from cultured astrocytes
mutations in erk2 binding sites affect nuclear entry
transcriptional control of cholesterol biosynthesis in schwann cells by axonal neuregulin 1
mechanism of activation of a g protein-coupled receptor, the human cholecystokinin-2 receptor
genome-scale reconstruction of metabolic network in bacillus subtilis based on high-throughput phenotyping and gene essentiality data
association of specific proteolytic processing of bone sialoprotein and bone acidic glycoprotein-75 with mineralization within biomineralization foci
involvement of the snake toxin receptor clec-2, in podoplanin-mediated platelet activation, by cancer cells
synthesis and catabolism of -hydroxybutyrate in sh-sy5y human neuroblastoma cells
s-cysteinylation is a general mechanism for thiol protection of bacillus subtilis proteins after oxidative stress
acylation determines the toll-like receptor (tlr)-dependent positive versus tlr2-, mannose receptor-, and signr1-independent negative regulation of pro-inflammatory..
role of a trna base modification and its precursors in frameshifting in eukaryotes
signaling and dna-binding activities of the staphylococcus aureus hssr-hsss two-component system required for heme sensing
oxidative stress-mediated mesangial cell proliferation requires rac-1/reactive oxygen species production and 4 integrin expression
trypsin iv or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia
role of c-abl in directing metabolic versus mitogenic effects in insulin receptor signaling
in vitro modeling of matrix vesicle nucleation
peroxisome proliferator-activated receptor interacts with ciita·rfx5 complex to repress type i collagen gene expression
molecular and functional characterization of a na+-k+ transporter from the trk family in the ectomycorrhizal fungus hebeloma cylindrosporum
study of bacteriophage t4-encoded dam dna (adenine-n6)-methyltransferase binding with substrates by rapid laser uv cross-linking
polysialylation increases lateral diffusion of neural cell adhesion molecule in the cell membrane
c-abl-mediated phosphorylation of wave3 is required for lamellipodia formation and cell migration
a nuclear export sequence located on a -strand in fibroblast growth factor-1
mitochondrial dysfunction and dendritic beading during neuronal toxicity
caspase-dependent cleavage disrupts the erk cascade scaffolding function of ksr1
small ubiquitin-related modifier (sumo)-specific proteases
establishing an ion pair interaction in the homomeric 1 -aminobutyric acid type a receptor that contributes to the gating pathway
up-regulation of acetyl-coa carboxylase and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
the chromatin remodeling protein, srcap, is critical for deposition of the histone variant h2a.z at promoters
cytoplasmic hsp70 promotes ubiquitination for endoplasmic reticulum-associated degradation of a misfolded mutant of the yeast plasma membrane atpase, pma1
the insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate erk1/2 activity in hek293 cells
differential subcellular localization of ric-3 isoforms and their role in determining 5-ht3 receptor composition
rfx1 mediates the serum-induced immediate early response of id2 gene expression
gtp-dependent recruitment of ciita to the class ii major histocompatibility complex promoter
rave is essential for the efficient assembly of the c subunit with the vacuolar h+-atpase
the missing link in the fungal d-galacturonate pathway
degradation of survivin by the x-linked inhibitor of apoptosis (xiap)-xaf1 complex
transforming growth factor 1-regulated xylosyltransferase i activity in human cardiac fibroblasts and its impact for myocardial remodeling
alternative splicing controls nuclear translocation of the cell cycle-regulated nek2 kinase
potential role for heparan sulfate proteoglycans in regulation of transforming growth factor- (tgf-) by modulating assembly of latent tgf--binding protein-1
a novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response
structural and functional studies of the hamp domain of envz, an osmosensing transmembrane histidine kinase in escherichia coli
translocation of activated heterotrimeric g protein go to ganglioside-enriched detergent-resistant membrane rafts in developing cerebellum
rbap48 is a critical mediator controlling the transforming activity of human papillomavirus type 16 in cervical cancer
soluble st2 blocks interleukin-33 signaling in allergic airway inflammation
rna and dna binding properties of hiv-1 vif protein
mitochondrial proteins bnip3 and bnip3l are involved in anthrax lethal toxin-induced macrophage cell death
distinct structural changes in a g protein-coupled receptor caused by different classes of agonist ligands
semaphorin-3a and semaphorin-3f work together to repel endothelial cells and to inhibit their survival by induction of apoptosis
modulation of serpin reaction through stabilization of transient intermediate by ligands bound to -helix f
proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of -aminobutyric acid type a receptors
partial reduction of bace1 has dramatic effects on alzheimer plaque and synaptic pathology in app transgenic mice
complexin/synaptotagmin interplay controls acrosomal exocytosis
a metalloantibody that irreversibly binds a protein antigen
peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2
noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation
tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2 in human lung cancer cells
human copper transporter hctr1 mediates basolateral uptake of copper into enterocytes
sgip1 is an endocytic protein that directly interacts with phospholipids and eps15
inositol pentakisphosphate mediates wnt/-catenin signaling
b- and c-raf display essential differences in their binding to ras
loss of the atp2c1 secretory pathway ca2+-atpase (spca1) in mice causes golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tu..
dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders
the tetraspan protein emp2 regulates expression of caveolin-1
ankyrin-g is a molecular partner of e-cadherin in epithelial cells and early embryos
the active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death
unique n-region determines low basal activity and limited inducibility of a-raf kinase
regulation of tryptophan hydroxylase-2 gene expression by a bipartite re-1 silencer of transcription/neuron restrictive silencing factor (rest/nrsf) binding motif
peroxisomes contain a specific phytanoyl-coa/pristanoyl-coa thioesterase acting as a novel auxiliary enzyme in - and -oxidation of methyl-branched fatty acids in mo..
antibodies use heme as a cofactor to extend their pathogen elimination activity and to acquire new effector functions
tissue-specific expression of klotho and fibroblast growth factor (fgf) receptor isoforms determines metabolic activity of fgf19 and fgf21
the human werner syndrome protein stimulates repair of oxidative dna base damage by the dna glycosylase neil1
solid-state nmr and functional measurements indicate that the conserved tyrosine residues of sarcolipin are involved directly in the inhibition of serca1
a process independent of the anaphase-promoting complex contributes to instability of the yeast s phase cyclin clb5
stb3 binds to ribosomal rna processing element motifs that control transcriptional responses to growth in saccharomyces cerevisiae
the cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of dna polymerase -interacting protein 38
insulin-like growth factor-i receptor mediates the prosurvival effect of fibronectin
implications for osteolytic bone metastases
a small membrane-peripheral region close to the active center determines regioselectivity of membrane-bound fatty acid desaturases from aspergillus nidulans
activation of targeted necrosis by a p53 peptide
v-src-mediated down-regulation of ssecks metastasis suppressor gene promoter by the recruitment of hdac1 into a usf1-sp1-sp3 complex
fibromodulin binds collagen type i via glu-353 and lys-355 in leucine-rich repeat 11
vascular endothelial growth factor (vegf)-induced up-regulation of ccn1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture ..
plasmodium falciparum erythrocyte membrane protein 3 (pfemp3) destabilizes erythrocyte membrane skeleton
chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (atm)-dependent senescence in p53-positive cancer cells
cxcl12 activates a robust transcriptional response in human prostate epithelial cells
distinct mechanisms for ctr1-mediated copper and cisplatin transport
glycosyltransferases involved in biosynthesis of the outer core region of escherichia coli lipopolysaccharides exhibit broader substrate specificities than is predi..
nicotine-induced activation of amp-activated protein kinase inhibits fatty acid synthase in 3t3l1 adipocytes
aeropin from the extremophile pyrobaculum aerophilum bypasses the serpin misfolding trap
monomers of the nhaa na+/h+ antiporter of escherichia coli are fully functional yet dimers are beneficial under extreme stress conditions at alkaline ph in the pres..
negative transcriptional regulation of multidrug resistance gene expression by an hsp70 protein
statins reduce amyloid- production through inhibition of protein isoprenylation
dislocation of an endoplasmic reticulum membrane glycoprotein involves the formation of partially dislocated ubiquitinated polypeptides
epigenetic silencing of tumor necrosis factor during endotoxin tolerance
the one-electron autoxidation of human cytochrome p450 3a4
transcription factor pu.1 controls transcription start site positioning and alternative tlr4 promoter usage
indirect activation of the epithelial na+ channel by trypsin
coactivators pgc-1 and src-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen
rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane
effects of discontinuities in the dna template on abortive initiation and promoter escape by escherichia coli rna polymerase
transcriptional regulation of bim by foxo3a mediates hepatocyte lipoapoptosis
new insights into the biosynthesis of mycobacterial lipomannan arising from deletion of a conserved gene
live cell monitoring of µ-opioid receptor-mediated g-protein activation reveals strong biological activity of close morphine biosynthetic precursors
phylogenetic diversity and the structural basis of substrate specificity in the /-barrel fold basic amino acid decarboxylases
attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group via phosp..
protein kinase c phosphorylation disrupts na+/h+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macro..
aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein vi, integrin 21, and von w..
biochemical characterization of msba from pseudomonas aeruginosa
engineered sarafotoxins as tissue inhibitor of metalloproteinases-like matrix metalloproteinase inhibitors
biological heterogeneity of the peptide-binding motif of the 70-kda heat shock protein by surface plasmon resonance analysis
a novel adp-forming succinyl-coa synthetase in thermococcus kodakaraensis structurally related to the archaeal nucleoside diphosphate-forming acetyl-coa synthetases
selection of protein phosphatase 2a regulatory subunits is mediated by the c terminus of the catalytic subunit
the structure of the r184a mutant of the inositol monophosphatase encoded by suhb and implications for its functional interactions in escherichia coli
live cell fret microscopy
electron transfer between cytochrome p450cin and its fmn-containing redox partner, cindoxin
a strategic protein in cytochrome c maturation
phosphatidylinositol ether lipid analogues that inhibit akt also independently activate the stress kinase, p38, through mkk3/6-independent and -dependent mechanisms
11-hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo..
extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/endo180, cooperate in fibroblast-mediated collage..
the hiv1 protein vpr acts to promote g2 cell cycle arrest by engaging a ddb1 and cullin4a-containing ubiquitin ligase complex using vprbp/dcaf1 as an adaptor
heightened sensitivity to paclitaxel in class iva -tubulin-transfected cells is lost as expression increases
immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations
bacillus stearothermophilus pcra monomer is a single-stranded dna translocase but not a processive helicase in vitro
anti-inflammatory effects of phosphatidylcholine
important role of the cys-191–cys-220 disulfide bond in thrombin function and allostery
treatment of pc12 cells with nerve growth factor induces proteasomal degradation of t-cadherin that requires tyrosine phosphorylation of its cadherin domain
leupaxin negatively regulates b cell receptor signaling
engineering the processive run length of myosin v
murine udp-glcnac:lysosomal enzyme n-acetylglucosamine-1-phosphotransferase lacking the -subunit retains substantial activity toward acid hydrolases
forced expression of survivin-2b abrogates mitotic cells and induces mitochondria-dependent apoptosis by blockade of tubulin polymerization and modulation of bcl-2,..
erk2-mediated c-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression
interleukin-17 stimulates c-reactive protein expression in hepatocytes and smooth muscle cells via p38 mapk and erk1/2-dependent nf-b and c/ebp activation
small ubiquitin-like modifier modification regulates the dna binding activity of glial cell missing drosophila homolog a
molecular cloning and characterization of a highly selective chemokine-binding protein from the tick rhipicephalus sanguineus
the thioredoxin system of the filamentous fungus aspergillus nidulans
genetic basis for the biosynthesis of methylglucose lipopolysaccharides in mycobacterium tuberculosis
liver-specific activities of fgf19 require klotho beta
skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
oxidative stress antagonizes wnt signaling in osteoblast precursors by diverting -catenin from t cell factor- to forkhead box o-mediated transcription
structure of the ebola fusion peptide in a membrane-mimetic environment and the interaction with lipid rafts
v5 integrin sustains growth of human pre-b cells through an rgd-independent interaction with a basic domain of the cd23 protein
luminal chloride-dependent activation of endosome calcium channels
high resolution crystal structures of mycobacterium tuberculosis adenosine kinase
the role of receptor oligomerization in modulating the expression and function of leukocyte adhesion-g protein-coupled receptors
molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the cxcr4 chemokine receptor
a new functional motif in hox domain-containing ceramide synthases
genetic analysis of the short splice variant of the inhibitor of caspase-activated dnase (icad-s) in chicken dt40 cells
persistent and stable gene expression by a cytoplasmic rna replicon based on a noncytopathic variant sendai virus
cd36 signals to the actin cytoskeleton and regulates microglial migration via a p130cas complex
the proprotein convertase ski-1/s1p
phospho-regulation of hscdc14a by polo-like kinase 1 is essential for mitotic progression
shedding of collagen xxiii is mediated by furin and depends on the plasma membrane microenvironment
hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction..
histone acetyltransferase halp and nuclear membrane protein hssun1 function in de-condensation of mitotic chromosomes
crystal structure of tapes japonica lysozyme with substrate analogue
the structure of the iron-binding protein, futa1, from synechocystis 6803
regulation of mouse slo gene expression
endocytotic internalization as a crucial factor for the cytotoxicity of ribonucleases
protein kinase d-mediated phosphorylation and nuclear export of sphingosine kinase 2
cellular internalization of green fluorescent protein fused with herpes simplex virus protein vp22 via a lipid raft-mediated endocytic pathway independent of caveol..
ubiquinone-binding site mutations in the saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinate
erk and mtor signaling couple -adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation
mutations within helix i of twist1 result in distinct limb defects and variation of dna binding affinities
structural basis for uba-mediated dimerization of c-cbl ubiquitin ligase
neua sialic acid o-acetylesterase activity modulates o-acetylation of capsular polysaccharide in group b streptococcus
faf1 suppresses ib kinase (ikk) activation by disrupting the ikk complex assembly
excision of 5-halogenated uracils by human thymine dna glycosylase
leptin induces cd40 expression through the activation of akt in murine dendritic cells
the transmembrane segment s6 determines cation versus anion selectivity of trpm2 and trpm8
redundancy of chromatin remodeling pathways for the induction of the yeast pho5 promoter in vivo
glucosamine hydrochloride specifically inhibits cox-2 by preventing cox-2 n-glycosylation and by increasing cox-2 protein turnover in a proteasome-dependent manner
the mitochondrial tom complex is required for tbid/bax-induced cytochrome c release
vibrio vulnificus ilpa-induced cytokine production is mediated by toll-like receptor 2
stomach-specific calpain, ncl-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through c2-like domains
intramolecular disulfide bond is a critical check point determining degradative fates of atp-binding cassette (abc) transporter abcg2 protein
biosynthesis of truncated n-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects
characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain ii as a myocilin-processing protease
an activated glutamate residue identified in photosystem ii at the interface between the manganese-stabilizing subunit and the d2 polypeptide
the significance of type ii and prxq peroxiredoxins for antioxidative stress response in the purple bacterium rhodobacter sphaeroides
discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects
an unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of veronica (veronica hederifolia l.)
regulator of g signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant 1-antitrypsin z in the classical form ..
cryoelectron tomographic analysis of an hiv-neutralizing protein and its complex with native viral gp120
yeast mitochondrial initiator trna is methylated at guanosine 37 by the trm5-encoded trna (guanine-n1-)-methyltransferase
assembly dynamics of mycobacterium tuberculosis ftsz
role of glycosylation in corin zymogen activation
a novel system for expressing toxic actin mutants in dictyostelium and purification and characterization of a dominant lethal yeast actin mutant
signaling pathways regulating tc21-induced tumorigenesis
sequential action of ets-1 and sp1 in the activation of the human -1,4-galactosyltransferase v gene involved in abnormal glycosylation characteristic of cancer cells
highly effective recombinant format of a humanized igg-like bispecific antibody for cancer immunotherapy with retargeting of lymphocytes to tumor cells
osmosensing properties of the histidine protein kinase mtrb from corynebacterium glutamicum
the complete pathway for erk2-catalyzed reaction
nuclear import of c-jun is mediated by multiple transport receptors
dual chromatin remodeling roles for rsc during dna double strand break induction and repair at the yeast mat locus
polypeptide substrate specificity of pslsmt
hip is a pro-survival substrate of granzyme b
gangliosides and nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells
the protein kinase ck2 phosphorylates snap190 to negatively regulate snapc dna binding and human u6 transcription by rna polymerase iii
identification of proteins released by mammalian cells that mediate dna internalization through proteoglycan-dependent macropinocytosis
chemical chaperones reduce endoplasmic reticulum stress and prevent mutant hfe aggregate formation
surface-exposed amino acid residues of hpv16 l1 protein mediating interaction with cell surface heparan sulfate
global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry
small molecule receptor agonists and antagonists of ccr3 provide insight into mechanisms of chemokine receptor activation
the role of distal s6 hydrophobic residues in the voltage-dependent gating of cav2.3 channels
smn-independent subunits of the smn complex
2-integrins and acquired glycoprotein iib/iiia (gpiib/iiia) receptors cooperate in nf-b activation of human neutrophils
functional redundancy between two caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism
the human cc chemokine mip-1 dimer is not competent to bind to the ccr5 receptor
crystal structures of human pantothenate kinases
impact of two novel mutations on the structure and function of human myeloperoxidase
xrcc1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from dna repair intermediates
intracellular trafficking pathway of yeast long-chain base kinase lcb4, from its synthesis to its degradation
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