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myogenin and the swi/snf atpase brg1 maintain myogenic gene expression at different stages of skeletal myogenesis
novel mechanism of activation of nadph oxidase
structural consequences of mutations in interfacial tyr residues of a protein antigen-antibody complex
structural analysis of xanthomonas xopd provides insights into substrate specificity of ubiquitin-like protein proteases
structure of atg5·atg16, a complex essential for autophagy
v6 is a novel receptor for human fibrillin-
the dynamic envelope of a fusion class ii virus
curcumin suppresses ap1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes
activation of multifarious transcription of an adhesion protein ap65-1 gene by a novel myb2 protein in the protozoan parasite trichomonas vaginalis
structural diversity of the hagfish variable lymphocyte receptors
calcium-dependent regulation of protein kinase d revealed by a genetically encoded kinase activity reporter
molecular properties of rhodopsin and rod function
heparin binding induces a conformational change in pigment epithelium-derived factor
expression of the calcium-binding protein s100a4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response
angiotensin ii inhibits the romk-like small conductance k channel in renal cortical collecting duct during dietary potassium restriction
a new membrane-bound cytochrome c works as an electron donor to the photosynthetic reaction center complex in the purple bacterium, rhodovulum sulfidophilum
two populations of p27 use differential kinetics to phosphorylate ser-10 and thr-187 via phosphatidylinositol 3-kinase in response to fibroblast growth factor-2 sti..
complete restoration of cell surface activity of transmembrane-truncated mt1-mmp by a glycosylphosphatidylinositol anchor
ras/erk1/2-mediated stat3 ser727 phosphorylation by familial medullary thyroid carcinoma-associated ret mutants induces full activation of stat3 and is required for..
spectropotentiometric and structural analysis of the periplasmic nitrate reductase from escherichia coli
reversible hexacoordination of -hemoglobin-stabilizing protein (ahsp)/-hemoglobin versus pressure
mutational analysis of phototropin 1 provides insights into the mechanism underlying lov2 signal transmission
15-deoxyspergualin primarily targets the trafficking of apicoplast proteins in plasmodium falciparum
activated epidermal growth factor receptor induces integrin 2 internalization via caveolae/raft-dependent endocytic pathway
electrostatic association of glutathione transferase to the nuclear membrane
phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced pc12 cell differentiation
prostate-derived sterile 20-like kinase 1- induces apoptosis
the transcriptional repressor gfi-1 antagonizes pu.1 activity through protein-protein interaction
scaffolding as an organizing principle in trans-translation
src docks to a-kinase anchoring protein gravin, regulating 2-adrenergic receptor resensitization and recycling
engineering the substrate specificity of staphylococcus aureus sortase a
ataxia telangiectasia mutated (atm) is essential for dna-pkcs phosphorylations at the thr-2609 cluster upon dna double strand break
prevention of peroxynitrite-induced apoptosis of motor neurons and pc12 cells by tyrosine-containing peptides
specific role of the truncated iv-spectrin 6 in sodium channel clustering at axon initial segments and nodes of ranvier
a single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells
oligomerization of the human prion protein proceeds via a molten globule intermediate
key features determining the specificity of aspartic proteinase inhibition by the helix-forming ia3 polypeptide
regulation of nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells
insights into the multiple roles of pausing in hiv-1 reverse transcriptase-promoted strand transfers
heat shock protein 27 functions in inflammatory gene expression and transforming growth factor--activated kinase-1 (tak1)-mediated signaling
rapid turnover of mcl-1 couples translation to cell survival and apoptosis
epithelial na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the -subunit
the dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension
dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-ht3a receptor
oxidoreductase interactions include a role for erp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf
the cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in hep3b cells
affinity and kinetic analysis of fc receptor iiia (cd16a) binding to igg ligands
functional and intracellular signaling differences associated with the helicobacter pylori alpab adhesin from western and east asian strains
radical sites in mycobacterium tuberculosis katg identified using electron paramagnetic resonance spectroscopy, the three-dimensional crystal structure, and electro..
functional analysis of norcoclaurine synthase in coptis japonica
coregulated ataxia telangiectasia-mutated and casein kinase sites modulate camp-response element-binding protein-coactivator interactions in response to dna damage
mitogen-activated protein kinase-dependent activation of the na+/h+ exchanger is mediated through phosphorylation of amino acids ser770 and ser771
transforming growth factor--independent regulation of myogenesis by snon sumoylation
lamina-associated polypeptide 2- forms homo-trimers via its c terminus, and oligomerization is unaffected by a disease-causing mutation
structural mechanism and photoprotective function of water-soluble chlorophyll-binding protein
the residues determining differences in ion affinities among the alternative splice variants f, a, and b of the mammalian renal na-k-cl cotransporter (nkcc2)
the local phospholipid environment modulates the activation of blood clotting
pu.1 activates transcription of shp-1 gene in hematopoietic cells
nmr structural characterization of a minimal peptide antagonist bound to the extracellular domain of the corticotropin-releasing factor1 receptor
tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice
ph dependence of copper geometry, reduction potential, and nitrite affinity in nitrite reductase
structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer
glutathione transferases sequester toxic dinitrosyl-iron complexes in cells
pu.1, interferon regulatory factor (irf) 2, and the interferon consensus sequence-binding protein (icsbp/irf8) cooperate to activate nf1 transcription in differenti..
conserved intermolecular salt bridge required for activation of protein kinases pkr, gcn2, and perk
idi2, a second isopentenyl diphosphate isomerase in mammals
-ketoglutaric semialdehyde dehydrogenase isozymes involved in metabolic pathways of d-glucarate, d-galactarate, and hydroxy-l-proline
the role of histone acetylation in regulating early gene expression patterns during early embryonic stem cell differentiation
biochemical characterization of a regulatory cascade controlling transcription of the pseudomonas aeruginosa type iii secretion system
ceramidase enhances phospholipase c-induced hemolysis by pseudomonas aeruginosa
roles of bound quinone in the single subunit nadh-quinone oxidoreductase (ndi1) from saccharomyces cerevisiae
keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of nf-b transcription factors
zinc induces dimerization of the class ii major histocompatibility complex molecule that leads to cooperative binding to a superantigen
xt-ii, the second isoform of human peptide-o-xylosyltransferase, displays enzymatic activity
chromatin remodeling of interleukin-17 (il-17)-il-17f cytokine gene locus during inflammatory helper t cell differentiation
regulation of pancreas duodenum homeobox-1 expression by early growth response-1
ubiquitin-interacting motifs inhibit aggregation of polyq-expanded huntingtin
phosphorylation of a wiscott-aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption
caveolin-1 triggers t-cell activation via cd26 in association with carma1
a novel regulator of telomerase
blockade of class ia phosphoinositide 3-kinase in neutrophils prevents nadph oxidase activation- and adhesion-dependent inflammation
unique ability of activated cd4+ t cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation
oxygen tension regulates the stability of insulin receptor substrate-1 (irs-1) through caspase-mediated cleavage
reaction mechanism of pyridoxal 5‘-phosphate synthase
f508 mutation results in impaired gastric acid secretion
interleukin-1 (il-1)-induced tak1-dependent versus mekk3-dependent nfb activation pathways bifurcate at il-1 receptor-associated kinase modification
the adenoviral e4orf6 protein induces atypical apoptosis in response to dna damage
identification of domains involved in tetramerization and malate inhibition of maize c4-nadp-malic enzyme
calcium-dependent and -independent binding of soybean calmodulin isoforms to the calmodulin binding domain of tobacco mapk phosphatase-1
synergistic potent insulin release by combinations of weak secretagogues in pancreatic islets and ins-1 cells
neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues
the spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes ca2+ waves
critical role for polar residues in coupling leukotriene b4 binding to signal transduction in blt1
structural and functional basis of cxcl12 (stromal cell-derived factor-1) binding to heparin
identification of the hiv-1 gp41 core-binding motif in the scaffolding domain of caveolin-1
annexin b12 is a sensor of membrane curvature and undergoes major curvature-dependent structural changes
structure and mechanism of helicobacter pylori fucosyltransferase
inhibition of familial cerebral amyloid angiopathy mutant amyloid -protein fibril assembly by myelin basic protein
the dynamics of the rapsyn scaffolding protein at individual acetylcholine receptor clusters
smar1-derived p44 peptide retains its tumor suppressor function through modulation of p53
crystal structure and function of the zinc uptake regulator furb from mycobacterium tuberculosis
cell confluence-induced activation of signal transducer and activator of transcription-3 (stat3) triggers epithelial dome formation via augmentation of sodium hydro..
g-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor
heteromeric assembly of human ether-à-go-go-related gene (herg) 1a/1b channels occurs cotranslationally via n-terminal interactions
alterations in linker flexibility suppress dna topoisomerase i mutant-induced cell lethality
impact of carrier stiffness and microtopology on two-dimensional kinetics of p-selectin and p-selectin glycoprotein ligand-1 (psgl-1) interactions
selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors tem8 and cmg2 and achieve targeting of tumor cells
sensor i threonine of the aaa+ atpase transcriptional activator pspf is involved in coupling nucleotide triphosphate hydrolysis to the restructuring of 54-rna polym..
the trp cage motif as a scaffold for the display of a randomized peptide library on bacteriophage t7
targeting of amsh to endosomes is required for epidermal growth factor receptor degradation
essential role of the jak/stat1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate
development of calpain-specific inactivators by screening of positional scanning epoxide libraries
hiv gp41 c-terminal heptad repeat contains multifunctional domains
mechanism of substrate recognition by botulinum neurotoxin serotype a
abca3 as a lipid transporter in pulmonary surfactant biogenesis
pancreatic acinar cells express vesicle-associated membrane protein 2- and 8-specific populations of zymogen granules with distinct and overlapping roles in secretion
tautomerism of histidine 64 associated with proton transfer in catalysis of carbonic anhydrase
structure-function analysis of arg-gly-asp helix motifs in v6 integrin ligands
combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor helix 12 dynamic behavior
p300/creb-binding protein interacts with atr and is required for the dna replication checkpoint
endofin, a fyve domain protein, interacts with smad4 and facilitates transforming growth factor- signaling
grail is up-regulated in cd4+ cd25+ t regulatory cells and is sufficient for conversion of t cells to a regulatory phenotype
identification of genes directly regulated by the oncogene znf217 using chromatin immunoprecipitation (chip)-chip assays
the structure of apolipoprotein a-ii in discoidal high density lipoproteins
swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase
crystal structure of the p38-mapkap kinase 2 heterodimer
structure of human eg5 in complex with a new monastrol-based inhibitor bound in the r configuration
the molecular basis for cyclopiazonic acid inhibition of the sarcoplasmic reticulum calcium pump
deletion of psbm in tobacco alters the qb site properties and the electron flow within photosystem ii
nuclear pregnane x receptor cross-talk with foxa2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver
activation of protein phosphatase 2a by palmitate inhibits amp-activated protein kinase
the gap junction protein connexin32 interacts with the src homology 3/hook domain of discs large homolog 1
the xaxab genes encoding a new apoptotic toxin from the insect pathogen xenorhabdus nematophila are present in plant and human pathogens
oxaloacetate hydrolase, the c-c bond lyase of oxalate secreting fungi
cathepsin l expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion
inhibition of gi2 activation by gi3 in cxcr3-mediated signaling
regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells
rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis
protein kinase c regulates internal initiation of translation of the gata-4 mrna following vasopressin-induced hypertrophy of cardiac myocytes
transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor nurr1 in cartilage
glycogen synthase kinase-3 represses cyclic amp response element-binding protein (creb)-targeted immediate early genes in quiescent cells
tak1 mapk kinase kinase mediates transforming growth factor- signaling by targeting snon oncoprotein for degradation
actions of aprataxin in multiple dna repair pathways
cdc7-dbf4 and the human s checkpoint response to uvc
chromatin remodeling by swi/snf results in nucleosome mobilization to preferential positions in the rat osteocalcin gene promoter
differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in drosophila mitochondrial dna helicase expresse..
insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3t3-l1 adipocytes
stabilization of hyperactive dihydrofolate reductase by cyanocysteine-mediated backbone cyclization
multiple residues in the transmembrane helix and connecting peptide of mouse tapasin stabilize the transporter associated with the antigen-processing tap2 subunit
protein kinase a phosphorylation of human phosphodiesterase 3b promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation
the stardust family protein mpp7 forms a tripartite complex with lin7 and dlg1 that regulates the stability and localization of dlg1 to cell junctions
evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds
protein kinase a-dependent translocation of hsp90 impairs endothelial nitric-oxide synthase activity in high glucose and diabetes
mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor
visual rhodopsin sees the light: structure and mechanism of g protein signaling
kinetic and mutational analyses of the major cytosolic exopolyphosphatase from saccharomyces cerevisiae
phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the dna-dependent protein kinase enhances its histone deacetylase..
resolvin d1 and its aspirin-triggered 17r epimer
membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid proteins
geminin cleavage during apoptosis by caspase-3 alters its binding ability to the swi/snf subunit brahma
a three amino acid tail following the tm4 region of the n-methyl-d-aspartate receptor (nr) 2 subunits is sufficient to overcome endoplasmic reticulum retention of n..
dimer structure of an interfacially impaired phosphatidylinositol-specific phospholipase c
identification of carboxyl-terminal mcm3 phosphorylation sites using polyreactive phosphospecific antibodies
requirement of vimentin filament assembly for 3-adrenergic receptor activation of erk map kinase and lipolysis
engineering a disulfide bond to stabilize the calcium-binding loop of activated protein c eliminates its anticoagulant but not its protective signaling properties
identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model
dissecting the n-terminal myosin binding site of human cardiac myosin-binding protein c
dynamic developmental elaboration of n-linked glycan complexity in the drosophila melanogaster embryo
direct binding of pp2a to sprouty2 and phosphorylation changes are a prerequisite for erk inhibition downstream of fibroblast growth factor receptor stimulation
dynamic assembly of trpc1-stim1-orai1 ternary complex is involved in store-operated calcium influx
functional analysis of mutations in the putative binding site for cystic fibrosis transmembrane conductance regulator potentiators
immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
site-specific conformational studies of prion protein (prp) amyloid fibrils revealed two cooperative folding domains within amyloid structure
cloning and characterization of a streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis
presenilin/-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (lar) receptor tyrosine phosphatase with -catenin
bone morphogenetic protein 1 prodomain specifically binds and regulates signaling by bone morphogenetic proteins 2 and 4
colonic anion secretory defects and metabolic acidosis in mice lacking the nbc1 cotransporter
clostridium difficile toxin b causes apoptosis in epithelial cells by thrilling mitochondria
tbp-interacting protein 120b (tip120b)/cullin-associated and neddylation-dissociated 2 (cand2) inhibits scf-dependent ubiquitination of myogenin and accelerates myo..
aqueous access pathways in atp synthase subunit a
the luminal vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive glut4-containing vesicles
identification of a signal peptide for unconventional secretion
ca2+-activated ik1 channels associate with lipid rafts upon cell swelling and mediate volume recovery
flow-induced alignment of amyloid protofilaments revealed by linear dichroism
oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
fungal peptide destruxin a plays a specific role in suppressing the innate immune response in drosophila melanogaster
fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin
contrasting behavior of higher plant photosystem i and ii antenna systems during acclimation
a novel arid/bright-like protein involved in transcriptional activation of cyst wall protein 1 gene in giardia lamblia
localization of cocaine analog [125i]rti 82 irreversible binding to transmembrane domain 6 of the dopamine transporter
electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the n-terminal domain of apoa-i in solution
pyrimethamine as a potential pharmacological chaperone for late-onset forms of gm2 gangliosidosis
tryptophan-scanning mutagenesis in the m3 transmembrane domain of the muscle-type acetylcholine receptor
neural stem/progenitor cells express 20 tenascin c isoforms that are differentially regulated by pax6
molecular basis of rna recognition by the embryonic polarity determinant mex-5
inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity
estimation of nitric oxide concentration in blood for different rates of generation
the function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors
rad4topbp1 associates with srr2, an spc1 mapk-regulated protein, in response to environmental stress
p200 rhogap promotes cell proliferation by mediating cross-talk between ras and rho signaling pathways
activation mechanism and steady state kinetics of bruton‘s tyrosine kinase
nrf2-keap1 signaling pathway regulates human ugt1a1 expression in vitro and in transgenic ugt1 mice
des--carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration
sequence preference in rna recognition by the nucleoporin nup153
interleukin-1-induced nf-b activation is nemo-dependent but does not require ikk
nipa1(spg6), the basis for autosomal dominant form of hereditary spastic paraplegia, encodes a functional mg2+ transporter
5-fluorouracil activation of p53 involves an mdm2-ribosomal protein interaction
a cation- interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block
the crystal structure of atg3, an autophagy-related ubiquitin carrier protein (e2) enzyme that mediates atg8 lipidation
attenuation of adipocyte triacylglycerol hydrolase activity decreases basal fatty acid efflux
nad(p)h oxidases regulate hif-2 protein expression
hiv-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro
identification of a novel chondroitin-sulfated collagen in the membrane separating theca and granulosa cells in chicken ovarian follicles
distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly
adiponectin sensitizes insulin signaling by reducing p70 s6 kinase-mediated serine phosphorylation of irs-1
apolipoprotein e4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner
decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked alzheimer disease families
gq-trpc6-mediated ca2+ entry induces rhoa activation and resultant endothelial cell shape change in response to thrombin
molecular interactions between masp-2, c4, and c2 and their activation fragments leading to complement activation via the lectin pathway
13c and 1h nmr studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes
structure-function analysis of the cuprous oxidase activity in fet3p from saccharomyces cerevisiae
phosphorylation of adult type sept5 (cdcrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1
endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase
anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine
interaction between human cathepsins k, l, and s and elastins
escherichia coli twin arginine (tat) mutant translocases possessing relaxed signal peptide recognition specificities
in vitro analysis of spure2p, a prion-related protein, exemplifies the relationship between amyloid and prion
oxygen metabolism by neuronal nitric-oxide synthase
the core histone tail domains contribute to sequence-dependent nucleosome positioning
paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an nad(p)h:paraquat oxidoreductase
post-transcriptional regulation of rnase-l expression is mediated by the 3‘-untranslated region of its mrna
extracellular matrix fibronectin increases prostaglandin e2 receptor subtype ep4 in lung carcinoma cells through multiple signaling pathways
the microtubule-binding protein hook3 interacts with a cytoplasmic domain of scavenger receptor a
c/ebp participates in regulating transcription of the p53 gene in response to mitogen stimulation
rhoa/rho kinase up-regulate bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis
the hop cassette of the pac1 receptor confers coupling to ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked neurosecretion
amp-activated protein kinase mediates carotid body excitation by hypoxia
targeting cal as a negative regulator of f508-cftr cell-surface expression
human biliverdin reductase, a previously unknown activator of protein kinase c ii
ganglioside gm2-tetraspanin cd82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse
pathogen recognition by toll-like receptor 2 activates weibel-palade body exocytosis in human aortic endothelial cells
how atp hydrolysis controls filament assembly from profilin-actin
regulation of nf-b-dependent gene expression by the pou domain transcription factor oct-1
structural and functional insights into intramolecular fructosyl transfer by inulin fructotransferase
genetically altered expression of spermidine/spermine n1-acetyltransferase affects fat metabolism in mice via acetyl-coa
two novel members of the ablim protein family, ablim-2 and -3, associate with stars and directly bind f-actin
rsk2 mediates muscle cell differentiation through regulation of nfat3
structure-based inhibitor design for an enzyme that binds different steroids
mutational study of heparan sulfate 2-o-sulfotransferase and chondroitin sulfate 2-o-sulfotransferase
high copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of wilson disease
mt1-mmp down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells
the c-myc target gene rcl (c6orf108) encodes a novel enzyme, deoxynucleoside 5‘-monophosphate n-glycosidase
uva induces granzyme b in human keratinocytes through mif
structure of eif3b rna recognition motif and its interaction with eif3j
oxidation and nitrosylation of cysteines proximal to the intermediate filament (if)-binding site of plectin
mechanism of abasic lesion bypass catalyzed by a y-family dna polymerase
sloppy bypass of an abasic lesion catalyzed by a y-family dna polymerase
identifying the membrane proteome of hiv-1 latently infected cells
interleukin-6 induces keratin expression in intestinal epithelial cells
mitochondrial genome integrity mutations uncouple the yeast saccharomyces cerevisiae atp synthase
post-translational arginylation of calreticulin
crystal structure of unautoprocessed precursor of subtilisin from a hyperthermophilic archaeon
the microrna let-7a modulates interleukin-6-dependent stat-3 survival signaling in malignant human cholangiocytes
both the n-terminal loop and wing w2 of the forkhead domain of transcription factor foxo4 are important for dna binding
junctional adhesion molecule-c promotes metastatic potential of ht1080 human fibrosarcoma
chromatin-dependent cooperativity between site-specific transcription factors in vivo
in vivo characterization and therapeutic efficacy of a c5-specific inhibitor from the soft tick ornithodoros moubata
specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eif5a) interaction
export pathway selectivity of escherichia coli twin arginine translocation signal peptides
epstein-barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, dhrs9
post-transcriptional up-regulation of adam17 upon epidermal growth factor receptor activation and in breast tumors
physical association between neuropeptide ff and µ-opioid receptors as a possible molecular basis for anti-opioid activity
tumor necrosis factor receptor 2 signaling induces selective c-iap1-dependent ask1 ubiquitination and terminates mitogen-activated protein kinase signaling
map4k4 gene silencing in human skeletal muscle prevents tumor necrosis factor--induced insulin resistance
multiple wasp-interacting protein recognition motifs are required for a functional interaction with n-wasp
changes in the balance between caldesmon regulated by p21-activated kinases and the arp2/3 complex govern podosome formation
caldendrin, a neuron-specific modulator of cav/1.2 (l-type) ca2+ channels
membrane-permeable calmodulin inhibitors (e.g. w-7/w-13) bind to membranes, changing the electrostatic surface potential
crystal structure of escherichia coli ketopantoate reductase in a ternary complex with nadp+ and pantoate bound
nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment
methylglyoxal inhibits the binding step of collagen phagocytosis
diploids heterozygous for a vma13 mutation in saccharomyces cerevisiae highlight the importance of v-atpase subunit balance in supporting vacuolar acidification and..
expression of rib-1, a caenorhabditis elegans homolog of the human tumor suppressor ext genes, is indispensable for heparan sulfate synthesis and embryonic morphoge..
iq-domain gtpase-activating protein 1 regulates -catenin at membrane ruffles and its role in macropinocytosis of n-cadherin and adenomatous polyposis coli
activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes
an on-pathway intermediate in the folding of a pdz domain
1-antitrypsin, old dog, new tricks
purification, reconstitution, and characterization of the cpxrap envelope stress system of escherichia coli
calcium influx through l-type channels generates protein kinase m to induce burst firing of dopamine cells in the rat ventral tegmental area
recognition of age-damaged (r,s)-adenosyl-l-methionine by two methyltransferases in the yeast saccharomyces cerevisiae
the recruitment of phosphatidylinositol 3-kinase to the e-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase c-1 activati..
epigenetic silencing of cyp24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol
regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases csg1 and csh1 by the ca2+-binding protein csg2
cu(i) binding and transfer by the n terminus of the wilson disease protein
adamts-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan
the influence of insertion of a critical residue (arg356) in structure and bioluminescence spectra of firefly luciferase
phorbol esters induce intracellular accumulation of the anti-apoptotic protein ped/pea-15 by preventing ubiquitinylation and proteasomal degradation
a multicopper ferroxidase involved in iron binding to transferrins in dunaliella salina plasma membranes
conformation-dependent stability of junctophilin 1 (jp1) and ryanodine receptor type 1 (ryr1) channel complex is mediated by their hyper-reactive thiols
glutathionylation of trypanosomal thiol redox proteins
the role of diacylglycerol lipase in constitutive and angiotensin at1 receptor-stimulated cannabinoid cb1 receptor activity
the glucose transporter 4-regulating protein tug is essential for highly insulin-responsive glucose uptake in 3t3-l1 adipocytes
enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation
concentrative export from the endoplasmic reticulum of the -aminobutyric acid transporter 1 requires binding to sec24d
hypomagnesemia with secondary hypocalcemia due to a missense mutation in the putative pore-forming region of trpm6
organismal differences in post-translational modifications in histones h3 and h4
tyrosine phosphorylation of missing in metastasis protein is implicated in platelet-derived growth factor-mediated cell shape changes
identification of histone h3 lysine 36 acetylation as a highly conserved histone modification
a novel role of the actin-nucleating arp2/3 complex in the regulation of rna polymerase ii-dependent transcription
trka receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal -secretase-mediated release of the p75 intra..
phospholipid biosynthesis program underlying membrane expansion during b-lymphocyte differentiation
viral infections activate types i and iii interferon genes through a common mechanism
identification of mitochondrial complex i assembly intermediates by tracing tagged ndufs3 demonstrates the entry point of mitochondrial subunits
ganglioside gd1a is an essential coreceptor for toll-like receptor 2 signaling in response to the b subunit of type iib enterotoxin
receptor subtype-specific docking of asp6.59 with c-terminal arginine residues in y receptor ligands
regulation of the nuclear poly(a)-binding protein by arginine methylation in fission yeast
human dna replication-related element binding factor (hdref) self-association via hatc domain is necessary for its nuclear accumulation and dna binding
-secretase-mediated release of the low density lipoprotein receptor-related protein 1b intracellular domain suppresses anchorage-independent growth of neuroglioma c..
the coxsackie and adenovirus receptor binds microtubules and plays a role in cell migration
thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1
fxyd6 is a novel regulator of na,k-atpase expressed in the inner ear
cd2ap/cin85 balance determines receptor tyrosine kinase signaling response in podocytes
a conserved cysteine residue of pichia pastoris pex20p is essential for its recycling from the peroxisome to the cytosol
fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1
human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the b-cell receptor
multiple residues in the second extracellular loop are critical for m3 muscarinic acetylcholine receptor activation
knockdown of aminopeptidase-n from helicoverpa armigera larvae and in transfected sf21 cells by rna interference reveals its functional interaction with bacillus th..
regulation of the gating of bkca channel by lipid bilayer thickness
phosphatase type 2a-dependent and -independent pathways for atr phosphorylation of chk1
maize -glucosidase-aggregating factor is a polyspecific jacalin-related chimeric lectin, and its lectin domain is responsible for -glucosidase aggregation
cd1d degradation in chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity
generation of inhibitory nfb complexes and phosphorylated camp response element-binding protein correlates with the anti-inflammatory activity of complement protein..
dlk1/fa1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related ..
akt and cdk5/p35 mediate brain-derived neurotrophic factor induction of darpp-32 in medium size spiny neurons in vitro
insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of foxo1 with androgen receptor
a singular bacteriophytochrome acquired by lateral gene transfer
mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics
regulatory mechanisms differ in ump kinases from gram-negative and gram-positive bacteria
participation of the c-terminal region of the d1-polypeptide in the first steps in the assembly of the mn4ca cluster of photosystem ii
nuclear calcium/calmodulin-dependent protein kinase ii preferentially transmits signals to histone deacetylase 4 in cardiac cells
identification of a novel domain at the n terminus of caveolin-1 that controls rear polarization of the protein and caveolae formation
chronic hexosamine flux stimulates fatty acid oxidation by activating amp-activated protein kinase in adipocytes
differential effects of arginine methylation on rbp16 mrna binding, guide rna (grna) binding, and grna-containing ribonucleoprotein complex (grnp) formation
identification of the last unknown genes in the fermentation pathway of lysine
neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (smm) chemokines
a neural-specific f-box protein fbs1 functions as a chaperone suppressing glycoprotein aggregation
dnak plays a pivotal role in tat targeting of cueo and functions beside slyd as a general tat signal binding chaperone
chloroplast-encoded polypeptide psbt is involved in the repair of primary electron acceptor qa of photosystem ii during photoinhibition in chlamydomonas reinhardtii
a bipartite sequence motif induces translation reinitiation in feline calicivirus rna
cooperativity in cytochrome p450 3a
heat shock factor 2 (hsf2) contributes to inducible expression of hsp genes through interplay with hsf1
a function for the subunit in loading the escherichia coli dna polymerase sliding clamp
burst kinetics and redox transformations of the active site manganese ion in oxalate oxidase
a histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hzip4, and protects against zinc cytotoxicity
caffeine promotes apoptosis in mitotic spindle checkpoint-arrested cells
expression of constitutively active stat3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages
prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis
regulation of s6 kinase 1 activation by phosphorylation at ser-411
mt1-mmp controls tumor-induced angiogenesis through the release of semaphorin 4d
multiple sequential steps involved in the binding of inhibitors to cytochrome p450 3a4
junb and jund regulate human heme oxygenase-1 gene expression in renal epithelial cells
nucleocytoplasmic shuttling of the nad+-dependent histone deacetylase sirt1
conditional activation of met in differentiated skeletal muscle induces atrophy
chemical interference of pathogen-associated molecular pattern-triggered immune responses in arabidopsis reveals a potential role for fatty-acid synthase type ii co..
zic2-dependent transcriptional regulation is mediated by dna-dependent protein kinase, poly(adp-ribose) polymerase, and rna helicase a
developmental regulation of eed complex composition governs a switch in global histone modification in brain
probing the roles of active site residues in the 3‘-5‘ exonuclease of the werner syndrome protein
crystal structures of an atp-dependent hexokinase with broad substrate specificity from the hyperthermophilic archaeon sulfolobus tokodaii
functional interaction between the transcription factor krüppel-like factor 5 and poly(adp-ribose) polymerase-1 in cardiovascular apoptosis
the brefeldin a-inhibited guanine nucleotide-exchange protein, big2, regulates the constitutive release of tnfr1 exosome-like vesicles
structural effects of naturally occurring human blood group b galactosyltransferase mutations adjacent to the dxd motif
glucose-stimulated cdc42 signaling is essential for the second phase of insulin secretion
cryptochrome blue light photoreceptors are activated through interconversion of flavin redox states
stat3 regulates cytokine-mediated generation of inflammatory helper t cells
bcl2 impedes dna mismatch repair by directly regulating the hmsh2-hmsh6 heterodimeric complex
the ear-motif of the cys2/his2-type zinc finger protein zat7 plays a key role in the defense response of arabidopsis to salinity stress
dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing hum..
structural characterization of human 8-oxoguanine dna glycosylase variants bearing active site mutations
the characterization and role of zinc binding in yeast cox4
aminosulfonate modulated ph-induced conformational changes in connexin26 hemichannels
the non-structural protein 4a of dengue virus is an integral membrane protein inducing membrane alterations in a 2k-regulated manner
identification, expression, and functional analyses of a thylakoid atp/adp carrier from arabidopsis
regulation of function by dimerization through the amino-terminal membrane-spanning domain of human abcc1/mrp1
an essential role of human ada3 in p53 acetylation
a plant homolog of animal chloride intracellular channels (clics) generates an ion conductance in heterologous systems
characterization of mutants that change the hydrogen bonding of the semiquinone radical at the qh site of the cytochrome bo3 from escherichia coli
extracellular production of hydrogen selenide accounts for thiol-assisted toxicity of selenite against saccharomyces cerevisiae
cadmium-responsive element of the human heme oxygenase-1 gene mediates heat shock factor 1-dependent transcriptional activation
association of protein biogenesis factors at the yeast ribosomal tunnel exit is affected by the translational status and nascent polypeptide sequence
distant n- and c-terminal domains are required for intrinsic kinase activity of smg-1, a critical component of nonsense-mediated mrna decay
modification of lipopolysaccharide with colanic acid (m-antigen) repeats in escherichia coli
binding mode of the first aminoacyl-trna in translation initiation mediated by plautia stali intestine virus internal ribosome entry site
the scaffolding adapter gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation
parasporin-1, a novel cytotoxic protein from bacillus thuringiensis, induces ca2+ influx and a sustained elevation of the cytoplasmic ca2+ concentration in toxin-se..
polyamine uptake by dur3 and sam3 in saccharomyces cerevisiae
transforming growth factor (tgf)-1 stimulates pulmonary fibrosis and inflammation via a bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12
global regulation of photosynthesis and respiration by fnrl
biochemical and functional analyses of the human toll-like receptor 3 ectodomain
apoptosis signal-regulating kinase (ask) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ask1
reaction of mycobacterium tuberculosis truncated hemoglobin o with hydrogen peroxide
src-p300 coactivator complex is required for thyroid hormone-induced amphibian metamorphosis
toward molecular dissection of prpc-prpsc interactions
modulation of the pancreatic islet -cell-delayed rectifier potassium channel kv2.1 by the polyunsaturated fatty acid arachidonate
essential role for caspase-8 in toll-like receptors and nfb signaling
unraveling the catalytic mechanism of nitrile hydratases
the p38/ mitogen-activated protein kinases mediate recruitment of creb-binding protein to preserve fast myosin heavy chain iid/x gene activity in myotubes
structure and orientation of the mn4ca cluster in plant photosystem ii membranes studied by polarized range-extended x-ray absorption spectroscopy
transcriptional and epigenetic regulation of interleukin-2 gene in activated t cells by morphine
trpa1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine
loss of vacuolar proton-translocating atpase activity in yeast results in chronic oxidative stress
ca2+ activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin
skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation
dual role of platelet protein kinase c in thrombus formation
coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in xbp-1(s)-induced endoplasmic reticulum biogenesis
repression of p53-mediated transcription by adenovirus e1b 55-kda does not require corepressor msin3a and histone deacetylases
effect of pseudophosphorylation and cross-linking by lipid peroxidation and advanced glycation end product precursors on tau aggregation and filament formation
redox sensitivity of the ryanodine receptor interaction with fk506-binding protein
shp-2 regulates cell growth by controlling the mtor/s6 kinase 1 pathway
human ssrp1 has spt16-dependent and -independent roles in gene transcription
5 integrin signaling regulates the formation of spines and synapses in hippocampal neurons
cxcr1 and cxcr2 activation and regulation
identification of the extracellular matrix (ecm) binding motifs of tissue inhibitor of metalloproteinases (timp)-3 and effective transfer to timp-1
cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
elucidation, quantitative refinement, and in vivo utilization of the hoxa13 dna binding site
structure and regulation of the human nek2 centrosomal kinase
the collagens of hydra provide insight into the evolution of metazoan extracellular matrices
a transgenic model reveals important roles for the nf-b alternative pathway (p100/p52) in mammary development and links to tumorigenesis
gh3-mediated auxin homeostasis links growth regulation with stress adaptation response in arabidopsis
genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy
molecular and functional analyses of a novel class i secretory nuclease from the human pathogen, leishmania donovani
membrane curvature alters the activation kinetics of the epithelial na+/h+ exchanger, nhe3
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