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diminished fad binding in the y459h and v492e antley-bixler syndrome mutants of human cytochrome p450 reductase
brain-derived neurotrophic factor activates erk5 in cortical neurons via a rap1-mekk2 signaling cascade
pak-interacting exchange factor-mediated rac1 activation requires smggds guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgro..
identification of an hexapeptide that binds to a surface pocket in cyclin a and inhibits the catalytic activity of the complex cyclin-dependent kinase 2-cyclin a
the il sequence in the llkil motif in cxcr2 is required for full ligand-induced activation of erk, akt, and chemotaxis in hl60 cells
nonpolar nucleobase analogs illuminate requirements for site-specific dna cleavage by vaccinia topoisomerase
regulation of amino acid transporter ata2 by ubiquitin ligase nedd4-2
mutational analysis of encephalitozoon cuniculi mrna cap (guanine-n7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltr..
identification and functional characterization of a monofunctional peroxisomal enoyl-coa hydratase 2 that participates in the degradation of even cis-unsaturated fa..
sugar-derived glasses support thermal and photo-initiated electron transfer processes over macroscopic distances
a novel function of ionotropic -aminobutyric acid receptors involving alveolar fluid homeostasis
-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and camp-response element-binding protein regulate oligodendrocyte excitotoxicity
a protease pathway for the repair of topoisomerase ii-dna covalent complexes
fission yeast homologs of human histone h3 lysine 4 demethylase regulate a common set of genes with diverse functions
genome-wide analysis of substrate specificities of the escherichia coli haloacid dehalogenase-like phosphatase family
the zinc finger protein ynr046w is plurifunctional and a component of the erf1 methyltransferase in yeast
the exchange factor and diacylglycerol receptor rasgrp3 interacts with dynein light chain 1 through its c-terminal domain
control of the p53-p21cip1 axis by e2f1, e2f2, and e2f3 is essential for g1/s progression and cellular transformation
study of claudin function by rna interference
functional characterization of the n-terminal region of myosin-2
dna unwinding by escherichia coli dna helicase i (trai) provides evidence for a processive monomeric molecular motor
atp-binding cassette transporter a1 expression disrupts raft membrane microdomains through its atpase-related functions
evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached -strand 1c
kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes
a novel -helix in the first fibronectin type iii repeat of the neural cell adhesion molecule is critical for n-glycan polysialylation
centaurin 1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent nf-b activation
nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor- signaling
size matters: erythromelalgia mutation s241t in nav1.7 alters channel gating
fluorometric measurements of intermolecular distances between the - and -subunits of the na+/k+-atpase
an archaeal peptidase assembles into two different quaternary structures
microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes
apoo, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart
ginsenoside-rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/akt and -catenin/t-c..
functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, bacteroides thetaiotaomicron, to the suckling period
identification and characterization of a protein-tyrosine phosphatase in leishmania
the long -helix of seca is important for the atpase coupling of translocation
fidelity of the human mitochondrial dna polymerase
incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial dna polymerase
link between mitochondria and nadph oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death
on parallel and antiparallel topology of a homodimeric multidrug transporter
the cytoplasmic substrate permeation pathway of serotonin transporter
expression of sumo-2/3 induced senescence through p53- and prb-mediated pathways
context-dependent dysregulation of transcription by mutant huntingtin
apolipoprotein e and low density lipoprotein receptor-related protein facilitate intraneuronal a42 accumulation in amyloid model mice
evaluation of the roles of apoptosis, autophagy, and mitophagy in the loss of plating efficiency induced by bax expression in yeast
legionella pneumophila induces ifn in lung epithelial cells via ips-1 and irf3, which also control bacterial replication
apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase c tyr311
mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2
neuralized-2 regulates a notch ligand in cooperation with mind bomb-1
the structure of the lingo-1 ectodomain, a module implicated in central nervous system repair inhibition
phosphatidylinositol 4-kinase iii regulates the transport of ceramide between the endoplasmic reticulum and golgi
the rab4a effector protein rabip4 is involved in migration of nih 3t3 fibroblasts
the role of ckip-1 in cell morphology depends on its interaction with actin-capping protein
spontaneous formation of l-isoaspartate and gain of function in fibronectin
tropomodulin 3 binds to actin monomers
opposing roles for akt1 and akt2 in rac/pak signaling and cell migration
a revised model for amp-activated protein kinase structure
transgenic expression of group v, but not group x, secreted phospholipase a2 in mice leads to neonatal lethality because of lung dysfunction
g protein-coupled receptor kinase and -arrestin-mediated desensitization of the angiotensin ii type 1a receptor elucidated by diacylglycerol dynamics
mnng-induced cell death is controlled by interactions between parp-1, poly(adp-ribose) glycohydrolase, and xrcc1
transactivation of sphingosine 1-phosphate receptors is essential for vascular barrier regulation
conditional deletion of shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated stat5 activation
proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular ca2+ and activation of protein kinase c
crystal structures of nonoxidative zinc-dependent 2,6-dihydroxybenzoate (-resorcylate) decarboxylase from rhizobium sp. strain mtp-10005
functional compensation for adipose differentiation-related protein (adfp) by tip47 in an adfp null embryonic cell line
structure of the calmodulin ii-spectrin complex provides insight into the regulation of cell plasticity
alloreactivity between disparate cognate and allogeneic pmhc-i complexes is the result of highly focused, peptide-dependent structural mimicry
integrin ligands mobilize ca2+ from ryanodine receptor-gated stores and lysosome-related acidic organelles in pulmonary arterial smooth muscle cells
nicotiana tabacum osmotic stress-activated kinase is regulated by phosphorylation on ser-154 and ser-158 in the kinase activation loop
regulatory factor interactions and somatic silencing of the germ cell-specific alf gene
-amyloid precursor protein is a direct cleavage target of htra2 serine protease
structural basis for the differential regulation of dna by the methionine repressor metj
prolyl-trnapro in the a-site of secm-arrested ribosomes inhibits the recruitment of transfer-messenger rna
the role of a conserved serine residue within hydrogen bonding distance of fad in redox properties and the modulation of catalysis by ca2+/calmodulin of constitutiv..
functional importance of the interhelical hydrogen bond between thr204 and tyr174 of sensory rhodopsin ii and its alteration during the signaling process
marco mediates silica uptake and toxicity in alveolar macrophages from c57bl/6 mice
antagonistic interactions of kleisins and dna with bacterial condensin mukb
regulation of cd4 expression via recycling by hres-1/rab4 controls susceptibility to hiv infection
seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking
rgs3 and rgs4 differentially associate with g protein-coupled receptor-kir3 channel signaling complexes revealing two modes of rgs modulation
human hepatitis b viral e antigen interacts with cellular interleukin-1 receptor accessory protein and triggers interleukin-1 response
control of phospholipid synthesis by phosphorylation of the yeast lipin pah1p/smp2p mg2+-dependent phosphatidate phosphatase
mu opioid receptor activation of erk1/2 is grk3 and arrestin dependent in striatal neurons
characterization and classification of atp-binding cassette transporter abca3 mutants in fatal surfactant deficiency
the import competence of a peroxisomal membrane protein is determined by pex19p before the docking step
the shb adapter protein is required for normal maturation of mesoderm during in vitro differentiation of embryonic stem cells
structure-function analysis and insights into the reduced toxicity of abrus precatorius agglutinin i in relation to abrin
induction of transcriptionally active jun proteins regulates drug-induced senescence
medium-chain fatty acids as ligands for orphan g protein-coupled receptor gpr84
mutational analysis of the medicago glycosyltransferase ugt71g1 reveals residues that control regioselectivity for (iso)flavonoid glycosylation
tuning of dnak chaperone action by nonnative protein sensor dnaj and thermosensor grpe
regulation of ncx1 expression
functional and biochemical analysis of the n-terminal domain of phytochrome a
transcription enhancer factor-1-dependent expression of the -tropomyosin gene in the three muscle cell types
ras triggers ataxia-telangiectasia-mutated and rad-3-related activation and apoptosis through sustained mitogenic signaling
an unorthodox bacteriophytochrome from rhodobacter sphaeroides involved in turnover of the second messenger c-di-gmp
the cell cycle inhibitor p21waf1 binds to the myc and cdc25a promoters upon dna damage and induces transcriptional repression
the anaphase-promoting complex/cyclosome inhibitor emi2 is essential for meiotic but not mitotic cell cycles
the ins and outs of myc regulation by posttranslational mechanisms
elafin prevents lipopolysaccharide-induced ap-1 and nf-b activation via an effect on the ubiquitin-proteasome pathway
critical role of vimentin phosphorylation at ser-56 by p21-activated kinase in vimentin cytoskeleton signaling
spatial compartmentalization of tumor necrosis factor (tnf) receptor 1-dependent signaling pathways in human airway smooth muscle cells
replication-dependent and -independent responses of rad18 to dna damage in human cells
bmi-1 regulates the differentiation and clonogenic self-renewal of i-type neuroblastoma cells in a concentration-dependent manner
spectroscopic and kinetic studies of the reaction of bromopropanesulfonate with methyl-coenzyme m reductase
cag pathogenicity island-independent up-regulation of matrix metalloproteinases-9 and -2 secretion and expression in mice by helicobacter pylori infection
involvement of the conserved adaptor protein alix in actin cytoskeleton assembly
functional categorization of the conserved basic amino acid residues in trmh (trna (gm18) methyltansferase) enzymes
neuronal pas domain protein 1 is a transcriptional repressor and requires arylhydrocarbon nuclear translocator for its nuclear localization
structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80r
acylation of cd44 and its association with lipid rafts are required for receptor and hyaluronan endocytosis
triad3a regulates ubiquitination and proteasomal degradation of rip1 following disruption of hsp90 binding
identification of an ahnak binding motif specific for the annexin2/s100a10 tetramer
frat1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase a
nitric oxide produced in response to engagement of 2 integrins on human neutrophils activates the monomeric gtpases rap1 and rap2 and promotes adhesion
heterogeneous nucleotide occupancy stimulates functionality of phage shock protein f, an aaa+ transcriptional activator
sensitivity of the yeast mitochondrial rna polymerase to +1 and +2 initiating nucleotides
id1 potentiates nf-b activation upon t cell receptor signaling
transglutaminase 2 mediates polymer formation of i-b through c-terminal glutamine cluster
ib kinase interacts with p52 and promotes transactivation via p65
characterization of novel splice variants of lgr7 and lgr8 reveals that receptor signaling is mediated by their unique low density lipoprotein class a modules
a novel mechanism of tissue inhibitor of metalloproteinases-1 activation by interleukin-1 in primary human astrocytes
hyaluronan constitutively regulates activation of multiple receptor tyrosine kinases in epithelial and carcinoma cells
kinetic effect of a downstream strand and its 5‘-terminal moieties on single nucleotide gap-filling synthesis catalyzed by human dna polymerase
activation mechanism for crac current and store-operated ca2+ entry
differences in hydration coupled to specific and nonspecific competitive binding and to specific dna binding of the restriction endonuclease bamhi
helicobacter pylori induces gastric epithelial cell invasion in a c-met and type iv secretion system-dependent manner
the chemistry of phospholipid binding by the saccharomyces cerevisiae phosphatidylinositol transfer protein sec14p as determined by epr spectroscopy
combination of nadph and copper ions generates proteinase k-resistant aggregates from recombinant prion protein
amp-activated protein kinase and the regulation of autophagic proteolysis
nitrated fatty acids: endogenous anti-inflammatory signaling mediators
insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains
neural cell adhesion molecule-associated polysialic acid inhibits nr2b-containing n-methyl-d-aspartate receptors and prevents glutamate-induced cell death
the inhibition of mitochondrial complex i (nadh:ubiquinone oxidoreductase) by zn2+
c-jun nh2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor ctbp
identification of the heparin-binding determinants within fibronectin repeat iii
a splice variant of cd99 increases motility and mmp-9 expression of human breast cancer cells through the akt-, erk-, and jnk-dependent ap-1 activation signaling pa..
dimerization of laforin is required for its optimal phosphatase activity, regulation of gsk3 phosphorylation, and wnt signaling
transcriptional regulatory cascade for elastase production in vibrio vulnificus
mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells
transient state kinetics of transcription elongation by t7 rna polymerase
a derivative of lipid a is involved in signal recognition particle/secyeg-dependent and -independent membrane integrations
blood group antigen recognition by a streptococcus pneumoniae virulence factor
identification of a dock180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of cdc42
involvement of helix 34 of 16 s rrna in decoding and translocation on the ribosome
ultra-efficient replication of infectious prions by automated protein misfolding cyclic amplification
regulation of legionella phagosome maturation and infection through flagellin and host ipaf
role of racc for the regulation of wasp and phosphatidylinositol 3-kinase during chemotaxis of dictyostelium
pegylation and multimerization of the anti-p185her-2 single chain fv fragment 4d
requirement for annexin a1 in plasma membrane repair
loss of cngb1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping
selection and characterization of her2 binding-designed ankyrin repeat proteins
knock-out mice reveal the contributions of p2y and p2x receptors to nucleotide-induced ca2+ signaling in macrophages
phosphorylation of specific serine residues in the pkr activation domain of pact is essential for its ability to mediate apoptosis
angiotensin ii-induced nadph oxidase activation impairs insulin signaling in skeletal muscle cells
identification of precise electrostatic recognition sites between cytochrome c6 and the photosystem i subunit psaf using mass spectrometry
structural basis for substrate binding and regioselective oxidation of monosaccharides at c3 by pyranose 2-oxidase
the wnt signaling receptor lrp5 is required for mammary ductal stem cell activity and wnt1-induced tumorigenesis
conformational changes mediate interleukin-10 receptor 2 (il-10r2) binding to il-10 and assembly of the signaling complex
transcriptional profiling of the protein phosphatase 2c family in yeast provides insights into the unique functional roles of ptc1
-actinin 4 potentiates myocyte enhancer factor-2 transcription activity by antagonizing histone deacetylase 7
gonadotropin-regulated testicular rna helicase (grth/ddx25) is a transport protein involved in gene-specific mrna export and protein translation during spermatogene..
the mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion
hcf164 receives reducing equivalents from stromal thioredoxin across the thylakoid membrane and mediates reduction of target proteins in the thylakoid lumen
cdca4 is an e2f transcription factor family-induced nuclear factor that regulates e2f-dependent transcriptional activation and cell proliferation
cytoplasmic targeting motifs control localization of toll-like receptor 9
suppressing wnt signaling by the hedgehog pathway through sfrp-1
act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor
critical role of the proline-rich region in huntingtin for aggregation and cytotoxicity in yeast
atp from subplasmalemmal mitochondria controls ca2+-dependent inactivation of crac channels
suppression of cancer cell migration and invasion by protein phosphatase 2a through dephosphorylation of µ- and m-calpains
structural rearrangements of sucrose phosphorylase from bifidobacterium adolescentis during sucrose conversion
tobacco etch virus mrna preferentially binds wheat germ eukaryotic initiation factor (eif) 4g rather than eifiso4g
a novel set domain methyltransferase in yeast
effects of the n-terminal domains of myosin binding protein-c in an in vitro motility assay
redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins
stored ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (stim1) via the ef-sam region
a novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression
differential transcriptional control of the superoxide dismutase-2 b element in neurons and astrocytes
the replication factor c clamp loader requires arginine finger sensors to drive dna binding and proliferating cell nuclear antigen loading
structural and functional insights into the regulation of arabidopsis agc viiia kinases
rho kinase differentially regulates phosphorylation of nonmuscle myosin ii isoforms a and b during cell rounding and migration
crystal structure of the galectin-9 n-terminal carbohydrate recognition domain from mus musculus reveals the basic mechanism of carbohydrate recognition
integrin 4 regulates migratory behavior of keratinocytes by determining laminin-332 organization
regulation of mapk-activated protein kinase 5 activity and subcellular localization by the atypical mapk erk4/mapk4
characterization of the atypical mapk erk4 and its activation of the mapk-activated protein kinase mk5
molecular basis for specificity of the extracytoplasmic thioredoxin resa
hiv gp120-induced interaction between cd4 and ccr5 requires cholesterol-rich microenvironments revealed by live cell fluorescence resonance energy transfer imaging
solution structures and backbone dynamics of a flavodoxin mioc from escherichia coli in both apo- and holo-forms
gaba increases both the conductance and mean open time of recombinant gabaa channels co-expressed with gabarap
spy1 expression prevents normal cellular responses to dna damage
demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method
skipping of exon 1 in the kcnq1 gene causes jervell and lange-nielsen syndrome
protein interactions within the set1 complex and their roles in the regulation of histone 3 lysine 4 methylation
interactions between tonb from escherichia coli and the periplasmic protein fhud
group via calcium-independent phospholipase a2 mediates endothelial cell s phase progression
identification of a novel apical sorting motif and mechanism of targeting of the m2 muscarinic acetylcholine receptor
a conserved subtilisin protease identified in babesia divergens merozoites
the role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation
evolution of a basic helix-loop-helix protein from a transcriptional repressor to a plastid-resident regulatory factor
temperature-sensitive eif5a mutant accumulates transcripts targeted to the nonsense-mediated decay pathway
the rac binding domain/irsp53-mim homology domain of irsp53 induces rac-dependent membrane deformation
regulation of the ring finger e3 ligase siah2 by p38 mapk
helix 8 of the viral chemokine receptor orf74 directs chemokine binding
the human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression
hormone-response genes are direct in vivo regulatory targets of brahma (swi/snf) complex function
streptococcal mitogenic exotoxin, smez, is the most susceptible m1t1 streptococcal superantigen to degradation by the streptococcal cysteine protease, speb
a highly specific mechanism of histone h3-k4 recognition by histone demethylase lsd1
cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2
activation of stat3 by gs distinctively requires protein kinase a, jnk, and phosphatidylinositol 3-kinase
tbid elicits a conformational alteration in membrane-bound bcl-2 such that it inhibits bax pore formation
the duck hepatitis b virus reverse transcriptase functions as a full-length monomer
a functional transsulfuration pathway in the brain links to glutathione homeostasis
energetics of ligand-induced conformational flexibility in the lactose permease of escherichia coli
the 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system
interdomain interactions in the tumor suppressor discs large regulate binding to the synaptic protein gukholder
krab can repress lentivirus proviral transcription independently of integration site
characterization of nobox dna binding specificity and its regulation of gdf9 and pou5f1 promoters
the potassium channel kat1 is activated by plant and animal 14-3-3 proteins
enzymatically active n-deacetylase/n-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate n-sulfation
modulation of collagen and mmp-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin
mdmx overexpression prevents p53 activation by the mdm2 inhibitor nutlin
hdmx modulates the outcome of p53 activation in human tumor cells
sumoylated snon represses transcription in a promoter-specific manner
mutual antagonism of target of rapamycin and calcineurin signaling
c-terminal src kinase-homologous kinase (chk), a unique inhibitor inactivating multiple active conformations of src family tyrosine kinases
identification of acid-base catalytic residues of high-mr thioredoxin reductase from plasmodium falciparum
lipopolysaccharide-induced cyclooxygenase-2 expression in human u937 macrophages is phosphatidic acid phosphohydrolase-1-dependent
functional cross-modulation between socs proteins can stimulate cytokine signaling
evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation
the mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1a is a major determinant of its malonyl-coa sensitivity
differential cleavage of eif4gi and eif4gii in mammalian cells
mechanistic analysis of a dna end processing pathway mediated by the xenopus werner syndrome protein
functional characterization of pmhs1, a pasteurella multocida heparosan synthase
elevated activity of stat3c due to higher dna binding affinity of phosphotyrosine dimer rather than covalent dimer formation
heat shock proteins 70 and 90 inhibit early stages of amyloid -(1-42) aggregation in vitro
protein kinase a-mediated phosphorylation of connexin36 in mouse retina results in decreased gap junctional communication between aii amacrine cells
the single transmembrane segment drives self-assembly of outc and the formation of a functional type ii secretion system in erwinia chrysanthemi
plant seed peroxygenase is an original heme-oxygenase with an ef-hand calcium binding motif
chondroitin sulfate perlecan enhances collagen fibril formation
coordinated regulation of the neisseria gonorrhoeae-truncated denitrification pathway by the nitric oxide-sensitive repressor, nsrr, and nitrite-insensitive narq-narp
insights into deglutathionylation reactions
identification of mapk phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1
structural determinants for phosphatidic acid regulation of phospholipase c-1
the marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway
coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein s..
abca1 overexpression in the liver of ldlr-ko mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis
gs activation is time-limiting in initiating receptor-mediated signaling
the anti-angiogenic activity of rpai-123 inhibits fibroblast growth factor-2 functions
insoluble mutant sod1 is partly oligoubiquitinated in amyotrophic lateral sclerosis mice
hsp90 functions in the targeting and outer membrane translocation steps of tom70-mediated mitochondrial import
a typical n-terminal extensions confer novel regulatory properties on gtp cyclohydrolase isoforms in drosophila melanogaster
pten regulates fibroblast elimination during collagen matrix contraction
repeated phosphopeptide motifs in human claspin are phosphorylated by chk1 and mediate claspin function
self-association of collagen triple helic peptides into higher order structures
regulation of fnr dimerization by subunit charge repulsion
n-glycosylation of the -propeller domain of the integrin 5 subunit is essential for 51 heterodimerization, expression on the cell surface, and its biological function
dyrk1a phosphorylates -synuclein and enhances intracellular inclusion formation
phosphorylation-independent ubiquitylation and endocytosis of fcriia
a viable amino acid editing activity in the leucyl-trna synthetase cp1-splicing domain is not required in the yeast mitochondria
yin yang 1 physically interacts with hoxa11 and represses hoxa11-dependent transcription
akap79-mediated targeting of the cyclic amp-dependent protein kinase to the 1-adrenergic receptor promotes recycling and functional resensitization of the receptor
identification and characterization of l-arabonate dehydratase, l-2-keto-3-deoxyarabonate dehydratase, and l-arabinolactonase involved in an alternative pathway of ..
identification of a peroxisomal acyl-activating enzyme involved in the biosynthesis of jasmonic acid in arabidopsis
germ cell nuclear factor is a repressor of cripto-1 and cripto-3
selective blockade of glycoprotein vi clustering on collagen helices
canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling
azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor
a specific dileucine motif is required for the gga-dependent entry of newly synthesized insulin-responsive aminopeptidase into the insulin-responsive compartment
the nr4a orphan nuclear receptor nor1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation
separating the anti-apoptotic and mitotic roles of survivin
the crystal and solution structures of glyceraldehyde-3-phosphate dehydrogenase reveal different quaternary structures
two crystal structures of the isochorismate pyruvate lyase from pseudomonas aeruginosa
dual signaling functions of the hybrid sensor kinase rpfc of xanthomonas campestris involve either phosphorelay or receiver domain-protein interaction
heme oxygenase-1 protects gastric mucosal cells against non-steroidal anti-inflammatory drugs
glutamine-dependent nad+ synthetase
rna editing by adar2 is metabolically regulated in pancreatic islets and -cells
the first luminal domain of vesicular monoamine transporters mediates g-protein-dependent regulation of transmitter uptake
art2, a t cell surface mono-adp-ribosyltransferase, generates extracellular poly(adp-ribose)
modulation of the cellular cholesterol level affects shedding of the type xiii collagen ectodomain
bm88 is a dual function molecule inducing cell cycle exit and neuronal differentiation of neuroblastoma cells via cyclin d1 down-regulation and retinoblastoma prote..
transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for fola..
neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2
human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation
structure and chemical inhibition of the ret tyrosine kinase domain
µ- and -opioids induce the differentiation of embryonic stem cells to neural progenitors
erp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with erp57
mapping atp-dependent activation at a 54 promoter
structural and mutational analysis of human ad37 and canine adenovirus 2 fiber heads in complex with the d1 domain of coxsackie and adenovirus receptor
sequence-specific interactions in the rna-binding domain of escherichia coli transcription termination factor rho
calcium-dependent modulation of poly(adp-ribose) polymerase-1 alters cellular metabolism and dna repair
real-time and single fibril observation of the formation of amyloid spherulitic structures
structure of the cadherin-related neuronal receptor/protocadherin- first extracellular cadherin domain reveals diversity across cadherin families
kinectin-dependent assembly of translation elongation factor-1 complex on endoplasmic reticulum regulates protein synthesis
sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in acat-competent macrophages
activation of ras up-regulates pro-apoptotic bnip3 in nitric oxide-induced cell death
necessary role for the lag1p motif in (dihydro)ceramide synthase activity
regulation of bone morphogenetic protein-4 by matrix gla protein in vascular endothelial cells involves activin-like kinase receptor 1
biochemistry of the initial steps of mycothiol biosynthesis
inhibition of fructose-1,6-bisphosphatase by aminoimidazole carboxamide ribotide prevents growth of salmonella enterica purh mutants on glycerol
dna-pkcs dependence of artemis endonucleolytic activity, differences between hairpins and 5‘ or 3‘ overhangs
a novel regulatory metal binding domain is present in the c terminus of arabidopsis zn2+-atpase hma2
molecular pathways regulating pro-migratory effects of hedgehog signaling
comparison of lipoteichoic acid from different serotypes of streptococcus pneumoniae
requirement of transmembrane transport for s-nitrosocysteine-dependent modification of intracellular thiols
the orphan nuclear receptor rev-erb regulates circadian expression of plasminogen activator inhibitor type 1
a crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism
first structure of a eukaryotic phosphohistidine phosphatase
protein repair in the brain, proteomic analysis of endogenous substrates for protein l-isoaspartyl methyltransferase in mouse brain
oxidative stress causes heart failure with impaired mitochondrial respiration
effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the c1 domain binding cleft in the atypical prot..
constitutive overexpression of nrf2-dependent heme oxygenase-1 in a549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate
two xyloglucan xylosyltransferases catalyze the addition of multiple xylosyl residues to cellohexaose
proteolytically processed soluble tumor endothelial marker (tem) 5 mediates endothelial cell survival during angiogenesis by linking integrin v3 to glycosaminoglycans
three complement-like repeats compose the complete 2-macroglobulin binding site in the second ligand binding cluster of the low density lipoprotein receptor-related..
molecular heterosis of prion protein -oligomers
arrestin-2 and g protein-coupled receptor kinase 5 interact with nfb1 p105 and negatively regulate lipopolysaccharide-stimulated erk1/2 activation in macrophages
an exonic splicing silencer is involved in the regulated splicing of glucose 6-phosphate dehydrogenase mrna
very long-chain fatty acid-containing lipids rather than sphingolipids per se are required for raft association and stable surface transport of newly synthesized pl..
coordination of jnk1 and jnk2 is critical for gadd45 induction and its mediated cell apoptosis in arsenite responses
s-nitrosylation of bcl-2 inhibits its ubiquitin-proteasomal degradation
identification of a filamin docking site on ptp-pest
ryanodine receptors in liver
mdm2-mediated nedd8 modification of tap73 regulates its transactivation function
distinct induction patterns and functions of two closely related interferon-inducible human genes, isg54 and isg56
biochemical, molecular, and functional characterization of piscf-allatostatin, a regulator of juvenile hormone biosynthesis in the mosquito aedes aegypti
clioquinol, a cu(ii)/zn(ii) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1, leading to expression of vascular end..
mitochondrial metabolism in developing embryos of brassica napus
specific epitopes of domains ii and iii of bacillus thuringiensis cry1ab toxin involved in the sequential interaction with cadherin and aminopeptidase-n receptors i..
regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain
phosphorylation of tyr1214 within vegfr-2 triggers the recruitment of nck and activation of fyn leading to sapk2/p38 activation and endothelial cell migration in re..
identification and characterization of a novel gene, mcpr1, and its possible function in the proliferation of embryonic palatal mesenchymal cells
a novel positive feedback loop between peroxisome proliferator-activated receptor- and prostaglandin e2 signaling pathways for human cholangiocarcinoma cell growth
glucocorticoids repress bcl-x expression in lymphoid cells by recruiting stat5b to the p4 promoter
procyclic trypanosoma brucei expresses separate sialidase and trans-sialidase enzymes on its surface membrane
aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in raw264.7 murine macrophages
evidence for specificity in lipid-rhodopsin interactions
sulfonylureas correct trafficking defects of disease-causing atp-sensitive potassium channels by binding to the channel complex
the human oct-4 isoforms differ in their ability to confer self-renewal
sgt1p is a unique co-chaperone that acts as a client adaptor to link hsp90 to skp1p
crystal structure of aminopeptidase n (proteobacteria alanyl aminopeptidase) from escherichia coli and conformational change of methionine 260 involved in substrate..
epstein-barr virus induces cellular transcription factors to allow active expression of eber genes by rna polymerase iii
cysteine-scanning mutagenesis and disulfide mapping studies of the conserved domain of the twin-arginine translocase tatb component
smad4-dependent regulation of urokinase plasminogen activator secretion and rna stability associated with invasiveness by autocrine and paracrine transforming growt..
functional analysis of cbpa, a dnaj homolog and nucleoid-associated dna-binding protein
psbi affects the stability, function, and phosphorylation patterns of photosystem ii assemblies in tobacco
novel splice variants of ing4 and their possible roles in the regulation of cell growth and motility
interaction of the membrane-bound glnk-amtb complex with the master regulator of nitrogen metabolism tnra in bacillus subtilis
mass spectrometric analysis of glycine receptor-associated gephyrin splice variants
identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme
the fibroblast growth factor receptor acid box is essential for interactions with n-cadherin and all of the major isoforms of neural cell adhesion molecule
dab1 and reelin effects on amyloid precursor protein and apoe receptor 2 trafficking and processing
serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro
crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation
triterpenoid cddo-me blocks the nf-b pathway by direct inhibition of ikk on cys-179
sulfated signal from asj sensory neurons modulates stomatin-dependent coordination in caenorhabditis elegans
investigating the qn site of the cytochrome bc1 complex in saccharomyces cerevisiae with mutants resistant to ilicicolin h, a novel qn site inhibitor
characterization of a new thermophilic spore photoproduct lyase from geobacillus stearothermophilus (splg) with defined lesion containing dna substrates
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