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secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
in vitro analysis of the escherichia coli amtb-glnk complex reveals a stoichiometric interaction and sensitivity to atp and 2-oxoglutarate
slco/oatp-like transport of glutathione in fasl-induced apoptosis
the cadmium transport sites of cada, the cd2+-atpase from listeria monocytogenes
magnesium, essential for base excision repair enzymes, inhibits substrate binding of n-methylpurine-dna glycosylase
purification, kinetic characterization, and molecular cloning of a novel enzyme, ecdysteroid 22-kinase
phospholipase c suppresses integrin activation
paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-b-containing lipoproteins
requirement of smad3 and creb-1 in mediating transforming growth factor- (tgf) induction of tgf3 secretion
differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular -amyloid-induced inhibition of complex iv and ..
the putative chloride channel hclca2 has a single c-terminal transmembrane segment
specific amino acids of the glycosyltransferase lpsa direct the addition of glucose or galactose to the terminal inner core heptose of haemophilus influenzae lipopo..
atp-consuming and atp-generating enzymes secreted by pancreas
brain-derived neurotrophic factor (bdnf)-induced synthesis of early growth response factor 3 (egr3) controls the levels of type a gaba receptor4 subunits in hippoca..
insertion of an arginine residue into the transmembrane segments corrects protein misfolding
tyrosine phosphorylation of the integrin 3 subunit regulates 3 cleavage by calpain
phosphorylation of ser-129 is the dominant pathological modification of -synuclein in familial and sporadic lewy body disease
growth factor-dependent akt activation and cell migration requires the function of c-k(b)-ras versus other cellular ras isoforms
effect of trb3 on insulin and nutrient-stimulated hepatic p70 s6 kinase activity
the protein kinase c catalytic fragment targets mcl-1 for degradation to trigger apoptosis
the tyrosine kinase c-abl protects c-jun from ubiquitination-mediated degradation in t cells
receptor-induced activation of drosophila trp by polyunsaturated fatty acids
unique biologic properties of recombinant aav1 transduction in polarized human airway epithelia
multiple antigenic mimotopes of hiv carbohydrate antigens
rgs2 inhibits the epithelial ca2+ channel trpv6
loss of caspase-9 provides genetic evidence for the type i/ii concept of cd95-mediated apoptosis
a dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from streptomyces griseus
substrate specificity of the adenylation enzyme sgcc1 involved in the biosynthesis of the enediyne antitumor antibiotic c-1027
human macrophage migration inhibitory factor
expression of mouse abcg2 mrna during hematopoiesis is regulated by alternative use of multiple leader exons and promoters
fibronectin increases matrix metalloproteinase 9 expression through activation of c-fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathway..
no change in glomerular heparan sulfate structure in early human and experimental diabetic nephropathy
lipidic antagonists to snare-mediated fusion
the phylogenetically conserved molluscan chitinase-like protein 1 (cg-clp1), homologue of human hc-gp39, stimulates proliferation and regulates synthesis of extrace..
alterations of tension-dependent atp utilization in a transgenic rat model of hypertrophic cardiomyopathy
yidc-mediated membrane insertion of assembly mutants of subunit c of the f1f0 atpase
regulation of hypocretin (orexin) expression in embryonic zebrafish
direct evidence for the modulation of the activity of the erwinia chrysanthemi quorum-sensing regulator expr by acylhomoserine lactone pheromone
the pdz scaffold nherf-2 interacts with mglur5 and regulates receptor activity
control of myod function during initiation of muscle differentiation by an autocrine signaling pathway activated by insulin-like growth factor-ii
androgen induction of prostate cancer cell invasion is mediated by ezrin
odorant binding and conformational dynamics in the odorant-binding protein
effect of the substitution of muscle actin-specific subdomain 1 and 2 residues in yeast actin on actin function
effects of conducting and blocking ions on the structure and stability of the potassium channel kcsa
bisandrographolide from andrographis paniculata activates trpv4 channels
engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for ret receptor-mediated cell survival
plasma protein -2-glycoprotein 1 mediates interaction between the anti-tumor monoclonal antibody 3g4 and anionic phospholipids on endothelial cells
comparative genomics and experimental characterization of n-acetylglucosamine utilization pathway of shewanella oneidensis
underexpressed coactivators pgc1 and src1 impair hepatocyte nuclear factor 4 function and promote dedifferentiation in human hepatoma cells
mutations in the intersubunit bridge regions of 23 s rrna
ion specificity and ionic strength dependence of the osmoregulatory abc transporter opua
structural and functional characterization of transmembrane segment vii of the na+/h+ exchanger isoform 1
crystal structure of unsaturated glucuronyl hydrolase complexed with substrate
fucosylation of n-glycans regulates the secretion of hepatic glycoproteins into bile ducts
structural rearrangements at the translocation pore of the human glutamate transporter, eaat1
enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
substrate recognition and catalysis by the exoribonuclease rnase r
reversible heart failure in gq transgenic mice
a src homology 3-binding sequence on the c terminus of sprouty2 is necessary for inhibition of the ras/erk pathway downstream of fibroblast growth factor receptor s..
identification of -aminobutyric acid receptor-interacting factor 1 (trak2) as a trafficking factor for the k+ channel kir2.1
the condensing activities of the mycobacterium tuberculosis type ii fatty acid synthase are differentially regulated by phosphorylation
cxcl12 induces tyrosine phosphorylation of cortactin, which plays a role in cxc chemokine receptor 4-mediated extracellular signal-regulated kinase activation and c..
both cleavage products of the mclca3 protein are secreted soluble proteins
ubiquitination of mhc class i heavy chains is essential for dislocation by human cytomegalovirus-encoded us2 but not us11
stat3 mediates interelukin-6 inhibition of human endothelial nitric-oxide synthase expression
regulation of gephyrin assembly and glycine receptor synaptic stability
ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest
essential role of protein kinase c in platelet signaling, iib3 activation, and thromboxane a2 release
dna binding properties of taf1 isoforms with two at-hooks
identification of a domain in the vo subunit d that is critical for coupling of the yeast vacuolar proton-translocating atpase
characterization of amyotrophic lateral sclerosis-linked p56s mutation of vesicle-associated membrane protein-associated protein b (vapb/als8)
interleukin-1 released by gp120 drives neural death through tyrosine phosphorylation and trafficking of nmda receptors
molecular network and chromosomal clustering of genes involved in synaptic plasticity in the hippocampus
structure-based functional annotation
function and structure of the molybdenum cofactor carrier protein from chlamydomonas reinhardtii
jab1 mediates cytoplasmic localization and degradation of west nile virus capsid protein
induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
excitation-contraction coupling in airway smooth muscle
characterization of distant enhancers and promoters in the albumin--fetoprotein locus during active and silenced expression
structural and functional evidence for the role of the tlr2 dd loop in tlr1/tlr2 heterodimerization and signaling
the bacterial signal molecule, ppgpp, mediates the environmental regulation of both the invasion and intracellular virulence gene programs of salmonella
oatp8/1b3-mediated cotransport of bile acids and glutathione
antigen processing of a short viral antigen by proteasomes
spectral and kinetic equivalence of oxidized cytochrome c oxidase as isolated and “activated“ by reoxidation
endoplasmic reticulum stress triggers autophagy
the pilz domain is a receptor for the second messenger c-di-gmp
structure of francisella tularensis acpa
efficient trafficking of ceramide from the endoplasmic reticulum to the golgi apparatus requires a vamp-associated protein-interacting ffat motif of cert
signal transfer from gpcrs to g proteins
prion protein helix1 promotes aggregation but is not converted into -sheet
an isoflavone conjugate-hydrolyzing -glucosidase from the roots of soybean (glycine max) seedlings
c-terminal truncation impairs glycosylation of transmembrane collagen xvii and leads to intracellular accumulation
tracking and elucidating alphavirus-host protein interactions
differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation
regulation of steady-state -amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme
distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel
p21waf1/cip1 suppresses keratinocyte differentiation independently of the cell cycle through transcriptional up-regulation of the igf-i gene
characterization of 3‘hexo, a 3‘ exonuclease specifically interacting with the 3‘ end of histone mrna
pro-urokinase-type plasminogen activator is a substrate for hepsin
conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein
transcriptional regulation of ulbp1, a human ligand of the nkg2d receptor
laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates
molecular mapping of the chloride-binding site in von willebrand factor (vwf)
perlecan proteolysis induces an 21 integrin- and src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation
a direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin
structure and dynamics of membrane-associated icp47, a viral inhibitor of the mhc i antigen-processing machinery
nf-b activation represses tumor necrosis factor--induced autophagy
identification of two domains involved in the assembly of transient receptor potential canonical channels
the deg proteases protect synechocystis sp. pcc 6803 during heat and light stresses but are not essential for removal of damaged d1 protein during the photosystem t..
deletion mutagenesis of p22phox subunit of flavocytochrome b55
a pyruvate cycling pathway involving cytosolic nadp-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion
protein-protein interactions in the archaeal transcriptional machinery
enhancer blocking by chicken -globin 5‘-hs
the proprotein convertase (pc) pcsk9 is inactivated by furin and/or pc5/6a
allelic gene regulation of pcdh- and pcdh- clusters involving both monoallelic and biallelic expression in single purkinje cells
molecular insights into nitrogenase femoco insertion
cloning and characterization of the annexin ii receptor on human marrow stromal cells
degradation of amyotrophic lateral sclerosis-linked mutant cu,zn-superoxide dismutase proteins by macroautophagy and the proteasome
competitive and cooperative interactions in receptor signaling complexes
the 4 regulatory subunit exerts opposing allosteric effects on protein phosphatases pp6 and pp2a
the translocation inhibitor cam741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon
cytotoxic t lymphocytes from cathepsin b-deficient mice survive normally in vitro and in vivo after encountering and killing target cells
identification of novel glycogen synthase kinase-3 substrate-interacting residues suggests a common mechanism for substrate recognition
the chk1-mediated s-phase checkpoint targets initiation factor cdc45 via a cdc25a/cdk2-independent mechanism
antisense inhibition of rnase p
immunophilin-like twisted dwarf1 modulates auxin efflux activities of arabidopsis p-glycoproteins
an induced fit conformational change underlies the binding mechanism of the heme transport proteobacteria-protein hems
biochemical fates of hemoglobin bound to hemoglobin-stabilizing protein ahsp
proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme
hypertonic stress increases phosphatidylinositol 4,5-bisphosphate levels by activating pip5ki
translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance
participation of the lys313-ile333 sequence of the purinergic p2x4 receptor in agonist binding and transduction of signals to the channel gate
g proteins g12 and g13 control the dynamic turnover of growth factor-induced dorsal ruffles
the thioredoxin domain of neisseria gonorrhoeae pilb can use electrons from dsbd to reduce downstream methionine sulfoxide reductases
isoaspartyl post-translational modification triggers anti-tumor t and b lymphocyte immunity
up-regulation of endogenous rgs2 mediates cross-desensitization between gs and gq signaling in osteoblasts
the cheys of rhodobacter sphaeroides
cyanobacterial small chlorophyll-binding protein scpd (hlib) is located on the periphery of photosystem ii in the vicinity of psbh and cp47 subunits
abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor
bovine complex i is a complex of 45 different subunits
fragment-based screening of the donor substrate specificity of human blood group b galactosyltransferase using saturation transfer difference nmr
unique membrane interaction mode of group iif phospholipase a2
retrocyclins kill bacilli and germinating spores of bacillus anthracis and inactivate anthrax lethal toxin
phospholemman phosphorylation alters its fluorescence resonance energy transfer with the na/k-atpase pump
siglec-7 undergoes a major conformational change when complexed with the (2,8)-disialylganglioside gt1b
structural basis for inhibition of protein-tyrosine phosphatase 1b by isothiazolidinone heterocyclic phosphonate mimetics
bone marrow plasminogen activator inhibitor-1 influences the development of obesity
laminin 1 chain lg4 module promotes cell attachment through syndecans and cell spreading through integrin 21
crystal structure of thrombin in a self-inhibited conformation
genome-wide analysis reveals new roles for the activation domains of the saccharomyces cerevisiae heat shock transcription factor (hsf1) during the transient heat s..
double-stranded dna binding, an unusual property of dna polymerase, promotes epigenetic silencing in saccharomyces cerevisiae
the molecular basis of rhoa specificity in the guanine nucleotide exchange factor pdz-rhogef
cannabinoid win 55,212-2 regulates trpv1 phosphorylation in sensory neurons
structural basis for the mechanistic understanding of human cd38-controlled multiple catalysis
eukaryotic initiation factor 2-independent pathway of stress granule induction by the natural product pateamine a
glutamine deamidation destabilizes human d-crystallin and lowers the kinetic barrier to unfolding
the last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase c
an intermediate ph unfolding transition abrogates the ability of ige to interact with its high affinity receptor fcri
two separate, conserved acidic amino acid domains within the toxoplasma gondii mic2 cytoplasmic tail are required for parasite survival
a point mutation in the sh1 helix alters elasticity and thermal stability of myosin ii
ttll7 is a mammalian -tubulin polyglutamylase required for growth of map2-positive neurites
structural analysis of septin 2, 6, and 7 complexes
differentiation arrest by hypoxia
p2y1 receptor-evoked glutamate exocytosis from astrocytes
caveolar endocytosis and microdomain association of a glycosphingolipid analog is dependent on its sphingosine stereochemistry
negative modulation of rxr transcriptional activity by small ubiquitin-related modifier (sumo) modification and its reversal by sumo-specific protease susp1
soluble aldose sugar dehydrogenase from escherichia coli
transition state of the sulfuryl transfer reaction of estrogen sulfotransferase
nqo1 and nqo2 regulation of humoral immunity and autoimmunity
src family kinases phosphorylate the bcr-abl sh3-sh2 region and modulate bcr-abl transforming activity
mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity
cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and runx2 expression
conversion of a putative agrobacterium sugar-binding protein into a fret sensor with high selectivity for sucrose
suppression of the lethality of high light to a quadruple hli mutant by the inactivation of the regulatory protein pfsr in synechocystis pcc 6803
neuroglycan c is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells
annexin v/5 integrin interactions regulate apoptosis of growth plate chondrocytes
function of the two xenopus smad4s in early frog development
the iron-sulfur cluster-free hydrogenase (hmd) is a metalloenzyme with a novel iron binding motif
defective mre11-dependent activation of chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent dna double strand b..
acyl coenzyme a-binding protein augments bid-induced mitochondrial damage and cell death by activating µ-calpain
role of protein kinase c-mediated protein phosphorylation in mitochondrial translocation of mouse cyp1a1, which contains a non-canonical targeting signal
crn7 interacts with ap-1 and is required for the maintenance of golgi morphology and protein export from the golgi
conformation of amyloid fibrils of 2-microglobulin probed by tryptophan mutagenesis
structural analysis of the regulatory dithiol-containing domain of the chloroplast atp synthase subunit
examination of key intermediates in the catalytic cycle of aspartate--semialdehyde dehydrogenase from a gram-positive infectious bacteria
binding of myotrophin/v-1 to actin-capping protein
controlling electron transfer in acyl-coa oxidases and dehydrogenases
membrane sorting of toll-like receptor (tlr)-2/6 and tlr2/1 heterodimers at the cell surface determines heterotypic associations with cd36 and intracellular targeting
suppression of cyclic gmp-dependent protein kinase is essential to the wnt/cgmp/ca2+ pathway
-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts
mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone
targeting protein kinase c activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling
structure of the thiazole biosynthetic enzyme thi1 from arabidopsis thaliana
degradation of escherichia coli recn aggregates by clpxp protease and its implications for dna damage tolerance
structures of ternary complexes of bphk, a bacterial glutathione s-transferase that reductively dechlorinates polychlorinated biphenyl metabolites
transcription factor activating enhancer-binding protein-
understanding the polymerization mechanism of glycoside-hydrolase family 70 glucansucrases
the polycystic kidney disease-1 gene is a target for p53-mediated transcriptional repression
interferon--inducible protein (ip)-10 mrna stabilized by rna-binding proteins in monocytes treated with s100b
phosphorylation of myosin phosphatase targeting subunit 3 (mypt3) and regulation of protein phosphatase 1 by protein kinase a
selenocompounds can serve as oxidoreductants with the methionine sulfoxide reductase enzymes
nuclear export of s6k1 ii is regulated by protein kinase ck2 phosphorylation at ser-17
functional role of the c terminus of human organic anion transporter hoat1
nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor--converting enzyme
the amino terminus of the human multidrug resistance transporter abcc1 has a u-shaped folding with a gating function
a dominant function of ikk/nf-b signaling in global lipopolysaccharide-induced gene expression
arrestin is required for agonist-induced trafficking of voltage-dependent calcium channels
contribution of interferon- to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide
the cmp-sialic acid transporter is localized in the medial-trans golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytop..
phosphorylation of shp-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced ca2+ signaling
oxygen tension regulates chondrocyte differentiation and function during endochondral ossification
quantitative analysis of anti-apoptotic function of akt in akt1 and akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions
pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired stat3 activation and association with transcriptional coactivators in hepatocytes
suberoylanilide hydroxamic acid induces akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of rela/p65
serpinb2 is an inducible host factor involved in enhancing hiv-1 transcription and replication
ca2+- and protein kinase c-dependent signaling pathway for nuclear factor-b activation, inducible nitric-oxide synthase expression, and tumor necrosis factor- produ..
the tail domain of myosin va modulates actin binding to one head
phospholipid hydroxyalkenals, a subset of recently discovered endogenous cd36 ligands, spontaneously generate novel furan-containing phospholipids lacking cd36 bind..
c-abl interacts with the wave2 signaling complex to induce membrane ruffling and cell spreading
intra- or intercomplex binding to the -secretase enzyme
transcriptional regulation of the glucose-6-phosphatase gene by camp/vasoactive intestinal peptide in the intestine
mechanism of cholesterol transfer from the niemann-pick type c2 protein to model membranes supports a role in lysosomal cholesterol transport
mutational analysis of the conserved tges loop of sarcoplasmic reticulum ca2+-atpase
identification of carotenoid cleavage dioxygenases from nostoc sp. pcc 7120 with different cleavage activities
the low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin
the first structure from the soul/hbp family of heme-binding proteins, murine p22hbp
metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization
structures of r- and t-state escherichia coli aspartokinase iii
oxylipin profiling of the hypersensitive response in arabidopsis thaliana
interactions between merozoite surface proteins 1, 6, and 7 of the malaria parasite plasmodium falciparum
the proform of the eosinophil major basic protein binds the cell surface through a site distinct from its c-type lectin ligand-binding region
the secreted protease factor cpaf is responsible for degrading pro-apoptotic bh3-only proteins in chlamydia trachomatis-infected cells
substrate specificity analysis of endoplasmic reticulum glucosidase ii using synthetic high mannose-type glycans
effects of factor xa and protein s on the individual activated protein c-mediated cleavages of coagulation factor va
as160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle
multiple degradation pathways for misfolded mutants of the yeast plasma membrane atpase, pma1
down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its co-chaperone chip
proteasome inhibitor ps-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of noxa
cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein
cross-species and cross-compartmental aminoacylation of isoaccepting trnas by a class ii trna synthetase
extracellular nad+ is an agonist of the human p2y11 purinergic receptor in human granulocytes
insulin-like growth factors mediate heterotrimeric g protein-dependent erk1/2 activation by transactivating sphingosine 1-phosphate receptors
the yeast ccr4-not complex controls ubiquitination of the nascent-associated polypeptide (nac-egd) complex
porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier
wnt/-catenin signaling is a normal physiological response to mechanical loading in bone
cuzn-sod deficiency causes apob degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice
site-specific phosphorylation differentiates active from inactive forms of the human t-cell leukemia virus type 1 tax oncoprotein
the reactions of heme- and verdoheme-heme oxygenase-1 complexes with fmn-depleted nadph-cytochrome p450 reductase
intracellular hiv-tat expression induces il-10 synthesis by the creb-1 transcription factor through ser133 phosphorylation and its regulation by the erk1/2 mapk in ..
significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor
phosphorylation and up-regulation of diacylglycerol kinase via its interaction with protein kinase c
caffeine targets tor complex i and provides evidence for a regulatory link between the frb and kinase domains of tor1p
polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases st8siaii and st8siaiv
ucp1-independent thermogenesis in white adipose tissue of cold-acclimated ucp1-/- mice
a model for the proteolipid ring and bafilomycin/concanamycin-binding site in the vacuolar atpase of neurospora crassa
apo- and holo-structures of 3-hydroxysteroid dehydrogenase from pseudomonas sp. b-083
structure and dynamics of asc2, a pyrin domain-only protein that regulates inflammatory signaling
crystal structure of the run domain of the rap2-interacting protein x
marfan syndrome-causing mutations in fibrillin-1 result in gross morphological alterations and highlight the structural importance of the second hybrid domain
comprehensive alanine-scanning mutagenesis of escherichia coli csra defines two subdomains of critical functional importance
identification of epi64 as a gtpase-activating protein specific for rab27a
control of listeria superoxide dismutase by phosphorylation
functional characterization of a gja1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma
the p14 fusion-associated small transmembrane (fast) protein effects membrane fusion from a subset of membrane microdomains
up-regulation of cyclin d1 by hbx is mediated by nf-b2/bcl3 complex through b site of cyclin d1 promoter
specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the ph/gram domain
renin enhancer is critical for control of renin gene expression and cardiovascular function
the wilms tumor suppressor wt1 promotes cell adhesion through transcriptional activation of the 4integrin gene
crystal structures of expressed non-polymerizable monomeric actin in the adp and atp states
cytoplasmic tail of phospholemman interacts with the intracellular loop of the cardiac na+/ca2+ exchanger
a conserved region in the ebl proteins is implicated in microneme targeting of the malaria parasite plasmodium falciparum
regulation of myosin v processivity by calcium at the single molecule level
interaction of phospholipase c-1 with villin regulates epithelial cell migration
mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis
role of hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function
temporal regulation of enhancer function in intestinal epithelium
ctip2 associates with the nurd complex on the promoter of p57kip2, a newly identified ctip2 target gene
novel mechanism of resistance to glycopeptide antibiotics in enterococcus faecium
ubiquilin 1 modulates amyloid precursor protein trafficking and a secretion
mechanisms by which bloom protein can disrupt recombination intermediates of okazaki fragment maturation
heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells
pkr1 encodes an assembly factor for the yeast v-type atpase
characterization of the substrate specificity of phld, a type iii polyketide synthase from pseudomonas fluorescens
functional consequences of mutations in cdkl5, an x-linked gene involved in infantile spasms and mental retardation
a novel nucleotide found in human erythrocytes, 4-pyridone-3-carboxamide-1--d-ribonucleoside triphosphate
thioredoxin-h1 reduces and reactivates the oxidized cytosolic malate dehydrogenase dimer in higher plants
paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice
monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of dna polymerase and mini-chromosome maintenance helica..
synergistic transmembrane alignment of the antimicrobial heterodimer pgla/magainin
proteinase-activated receptors, targets for kallikrein signaling
reduced dntp interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer
n-acetylglucosaminyltransferase iii antagonizes the effect of n-acetylglucosaminyltransferase v on 31 integrin-mediated cell migration
molecular and functional interactions between escherichia coli nucleoside-diphosphate kinase and the uracil-dna glycosylase ung
rip140 expression is stimulated by estrogen-related receptor during adipogenesis
cytosolic proteins regulate -synuclein dissociation from presynaptic membranes
a conserved nxip motif is required for cell adhesion properties of the syndecan-4 ectodomain
erk5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor (ppar) stimulation
differential engagement of modules 1 and 4 of vascular cell adhesion molecule-1 (cd106) by integrins 41 (cd49d/29) and m2 (cd11b/18) of eosinophils
the cop9 signalosome regulates skp2 levels and proliferation of human cells
the arginase ii gene is an anti-inflammatory target of liver x receptor in macrophages
dissecting the role of 5‘-amp for allosteric stimulation, activation, and deactivation of amp-activated protein kinase
high resolution characterization of formamidopyrimidine-dna glycosylase interaction with its substrate by chemical cross-linking and mass spectrometry using substra..
structural basis and functional consequence of helicobacter pylori caga multimerization in cells
rat spongiotrophoblast-specific protein is predominantly a unique low sulfated chondroitin sulfate proteoglycan
tcr and tcr-cd28 engagement of protein kinase b (pkb/akt) and glycogen synthase kinase-3 (gsk-3) operates independently of guanine nucleotide exchange factor vav-1
gib2, a novel g-like/rack1 homolog, functions as a g subunit in camp signaling and is essential in cryptococcus neoformans
the ephb4 receptor-tyrosine kinase promotes the migration of melanoma cells through rho-mediated actin cytoskeleton reorganization
requirement of protein kinase d tyrosine phosphorylation for vegf-a165-induced angiogenesis through its interaction and regulation of phospholipase c phosphorylation
crystal structure and desulfurization mechanism of 2‘-hydroxybiphenyl-2-sulfinic acid desulfinase
homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of trpc3 to the plasma membrane
effects of oncogenic mutations and dna response elements on the binding of p53 to p53-binding protein 2 (53bp2)
structural and functional analysis of a conjugated bile salt hydrolase from bifidobacterium longum reveals an evolutionary relationship with penicillin v acylase
structure of the full-length enzyme i of the phosphoenolpyruvate-dependent sugar phosphotransferase system
interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with g protein-coupled signal transduction but not agonist-mediated intern..
role of amino acid side chains in region 17-31 of parathyroid hormone (pth) in binding to the pth receptor
calreticulin represses e-cadherin gene expression in madin-darby canine kidney cells via slug
invariant leu preceding turn motif phosphorylation site controls the interaction of protein kinase c with hsp70
the role of the hybrid cluster protein in oxidative stress defense
saposin a mobilizes lipids from low cholesterol and high bis(monoacylglycerol)phosphate-containing membranes
the exon 6abc region of amelogenin mrna contribute to increased levels of amelogenin mrna through amelogenin protein-enhanced mrna stabilization
effect of dna modifications on dna processing by hiv-1 integrase and inhibitor binding
a cysteine-scanning mutagenesis study of transmembrane domain 8 of the electrogenic sodium/bicarbonate cotransporter nbce1
dichotomic phylogenetic tree of the pyruvate kinase family
mutant analysis of the shal (kv4) voltage-gated fast transient k+ channel in caenorhabditis elegans
regulatory interactions between ubiquinol oxidation and ubiquinone reduction sites in the dimeric cytochrome bc1 complex
the unorthodox snap50 zinc finger domain contributes to cooperative promoter recognition by human snapc
role of glutamine depletion in directing tissue-specific nutrient stress responses to l-asparaginase
e2f1 modulates p38 mapk phosphorylation via transcriptional regulation of ask1 and wip1
transient activation and delayed inhibition of na+,k+,cl- cotransport in atp-treated c11-mdck cells involve distinct p2y receptor subtypes and signaling mechanisms
secreted neutral metalloproteases of bacillus anthracis as candidate pathogenic factors
crystallographic analysis of calcium-dependent heparin binding to annexin a2
human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented ctp-binding site
glutathionylation induces the dissociation of 1-cys d-peroxiredoxin non-covalent homodimer
orientation of the tyrosyl radical in salmonella typhimurium class ib ribonucleotide reductase determined by high field epr of r2f single crystals
twisted gastrulation modulates bone morphogenetic protein-induced collagen ii and x expression in chondrocytes in vitro and in vivo
clathrin required for phosphorylation and internalization of 2-adrenergic receptor by g protein-coupled receptor kinase 2 (grk2)
csk-binding protein mediates sequential enzymatic down-regulation and degradation of lyn in erythropoietin-stimulated cells
allosteric control of cyclic di-gmp signaling
the c-terminal domain of escherichia coli trigger factor represents the central module of its chaperone activity
the polypyrimidine tract-binding protein (ptb) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression
domain and nucleotide dependence of the interaction between saccharomyces cerevisiae translation elongation factors 3 and 1a
the a-site finger in 23 s rrna acts as a functional attenuator for translocation
the quinone binding site in escherichia coli succinate dehydrogenase is required for electron transfer to the heme b
the actin cross-linking domain of the vibrio cholerae rtx toxin directly catalyzes the covalent cross-linking of actin
toward elucidating the membrane topology of helix two of the colicin e1 channel domain
anthrax edema factor, voltage-dependent binding to the protective antigen ion channel and comparison to lf binding
cloning and characterization of deoxymugineic acid synthase genes from graminaceous plants
identification of common and unique peptide substrate preferences for the udp-galnac:polypeptide -n-acetylgalactosaminyltransferases t1 and t2 derived from oriented..
disruption of extracellular matrix structure may cause pseudoachondroplasia phenotypes in the absence of impaired cartilage oligomeric matrix protein secretion
arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms
disruption of a tight cluster surrounding tyrosine 131 in the native conformation of antithrombin iii activates it for factor xa inhibition
identification of a tyrosine-based motif (ygsi) in the amino terminus of nramp1 (slc11a1) that is important for lysosomal targeting
age-specific cugbp1-eif2 complex increases translation of ccaat/enhancer-binding protein in old liver
gata-4 incompletely substitutes for gata-1 in promoting both primitive and definitive erythropoiesis in vivo
cgmp-dependent protein kinase type i inhibits tab1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes
akt2 regulates cardiac metabolism and cardiomyocyte survival
modulation of galt1 and sialt1 sub-golgi localization by sialt2 expression reveals an organellar level of glycolipid synthesis control
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