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rapid turnover of unspliced xbp-1 as a factor that modulates the unfolded protein response
solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3
real time single cell analysis of bid cleavage and bid translocation during caspase-dependent and neuronal caspase-independent apoptosis
the endonuclease domain of bacteriophage terminases belongs to the resolvase/integrase/ribonuclease h superfamily
the structure of leishmania mexicana icp provides evidence for convergent evolution of cysteine peptidase inhibitors
selective loss of fine tuning of gq/11 signaling by rgs2 protein exacerbates cardiomyocyte hypertrophy
acetobacter turbidans -amino acid ester hydrolase
docking studies show that d-glucose and quercetin slide through the transporter glut1
origin of informational polymers
isoform specificity of ankyrin-b
mcl-1 interacts with truncated bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis
fusion peptide of influenza hemagglutinin requires a fixed angle boomerang structure for activity
ligands for the -glucan receptor, dectin-1, assigned using “designer“ microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides
a novel protease inhibitor of the 2-macroglobulin family expressed in the human epidermis
protein kinase c regulates ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to dna damage
tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor
dynamics of the upper 50-kda domain of myosin v examined with fluorescence resonance energy transfer
the presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells
the pii signal transduction protein of arabidopsis thaliana forms an arginine-regulated complex with plastid n-acetyl glutamate kinase
suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-b activation
sodium and epithelial sodium channels participate in the regulation of the capacitation-associated hyperpolarization in mouse sperm
euglena gracilis ribonucleotide reductase
interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells
stimulation of dna strand exchange by the human tbpip/hop2-mnd1 complex
identification of fungal sphingolipid c9-methyltransferases by phylogenetic profiling
antiapoptotic effects of erythropoietin in differentiated neuroblastoma sh-sy5y cells require activation of both the stat5 and akt signaling pathways
reverse gyrase functions as a dna renaturase
mouse sperm lacking adam1b/adam2 fertilin can fuse with the egg plasma membrane and effect fertilization
kinetics of the atp hydrolysis cycle of the nucleotide-binding domain of mdl1 studied by a novel site-specific labeling technique
direct regulation of myelin protein zero expression by the egr2 transactivator
feed forward cycle of hypotonic stress-induced atp release, purinergic receptor activation, and growth stimulation of prostate cancer cells
expression of flr1 transporter requires phospholipase c and is repressed by mediator
hemoglobin is expressed by alveolar epithelial cells
nf-b regulates phagocytic nadph oxidase by inducing the expression of gp91phox
sumoylation inhibits cleavage of sp1 n-terminal negative regulatory domain and inhibits sp1-dependent transcription
socs1 inhibits tumor necrosis factor-induced activation of ask1-jnk inflammatory signaling by mediating ask1 degradation
phosphodiesterase-5 gln817 is critical for cgmp, vardenafil, or sildenafil affinity
carbon catabolite repression regulates amino acid permeases in saccharomyces cerevisiae via the tor signaling pathway
the histone chaperone asf1 increases the rate of histone eviction at the yeast pho5 and pho8 promoters
regulation of cytosolic phospholipase a2 activation and cyclooxygenase 2 expression in macrophages by the -glucan receptor
serum opacity factor, a streptococcal virulence factor that binds to apolipoproteins a-i and a-ii and disrupts high density lipoprotein structure
structural regions of md-2 that determine the agonist-antagonist activity of lipid iva
transportin is a major nuclear import receptor for c-fos
the glutamic acid-rich protein-2 (garp2) is a high affinity rod photoreceptor phosphodiesterase (pde6)-binding protein that modulates its catalytic properties
cyanobacterial clpc/hsp100 protein displays intrinsic chaperone activity
oligomers of tha4 organize at the thylakoid tat translocase during protein transport
membrane insertion of escherichia coli -hemolysin is independent from membrane lysis
effects of a leukemia-associated gain-of-function mutation of shp-2 phosphatase on interleukin-3 signaling
quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells
cathepsin d is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide dcd-1l
4‘-phosphopantetheine biosynthesis in archaea
creb-ap1 protein complexes regulate transcription of the collagen xxiv gene (col24a1) in osteoblasts
follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis
critical elements of oligosaccharide acceptor substrates for the pasteurella multocida hyaluronan synthase
physical and functional interactions of the cytomegalovirus us6 glycoprotein with the transporter associated with antigen processing
6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase c
the nerve hemoglobin of the bivalve mollusc spisula solidissima
prediction of mitochondrial proteins using support vector machine and hidden markov model
overexpression of heparan sulfate 6-o-sulfotransferases in human embryonic kidney 293 cells results in increased n-acetylglucosaminyl 6-o-sulfation
extracellular matrix-mediated signaling by dentin phosphophoryn involves activation of the smad pathway independent of bone morphogenetic protein
insulin antagonizes ischemia-induced thr172 phosphorylation of amp-activated protein kinase -subunits in heart via hierarchical phosphorylation of ser485/491
involvement of endoplasmic reticulum stress in hereditary tyrosinemia type i
high resolution crystal structures and molecular dynamics studies reveal substrate binding in the porin omp32
structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase
rapid degradation of bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons
latent nitrate transport activity of a novel sulfate permease-like protein of the cyanobacterium synechococcus elongatus
tumor cells enhance their own cd44 cleavage and motility by generating hyaluronan fragments
structural interactions between fxyd proteins and na+,k+-atpase
nucleotide-binding sites in the voltage-dependent anion channel
characterization of a novel interaction between elmo1 and erm proteins
chronic inhibition of cardiac kir2.1 and herg potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking
modulation of streptomyces leucine aminopeptidase by calcium
peptidoglycan recognition proteins are a new class of human bactericidal proteins
topology of the porin mspa in the outer membrane of mycobacterium smegmatis
ablation of mouse phosphomannose isomerase (mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality
inhibition of werner syndrome helicase activity by benzopyrene diol epoxide adducts can be overcome by replication protein a
the smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3‘-kinase and enhance platelet-derived growth factor receptor down-regulation
3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex ii, forms a covalent adduct with a catalytic base arginine..
structure of microsomal cytochrome p450 2b4 complexed with the antifungal drug bifonazole
identification and functions of chondroitin sulfate in the milieu of neural stem cells
proteoglycan mechanics studied by single-molecule force spectroscopy of allotypic cell adhesion glycans
sec14 homology domain targets p50rhogap to endosomes and provides a link between rab and rho gtpases
tab-1 modulates intracellular localization of p38 map kinase and downstream signaling
processivity of chimeric class v myosins
the crystal structure of (s)-3-o-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme
mechanism of chain selection in the assembly of collagen iv
phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts
cathepsin s controls angiogenesis and tumor growth via matrix-derived angiogenic factors
crystal structure of a bacterial type ib dna topoisomerase reveals a preassembled active site in the absence of dna
assembly of active zone precursor vesicles
inheritable histone h4 acetylation of somatic chromatins in cloned embryos
regulation of fibroblast growth factor-23 signaling by klotho
overexpression of cytosolic group iva phospholipase a2 protects cells from ca2+-dependent death
inducible phosphorylation of nf-b p65 at serine 468 by t cell costimulation is mediated by ikk
a peroxisome proliferator-activated receptor- agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosin..
nuclear transportation of diacylglycerol kinase and its possible function in the nucleus
dynamic ligation properties of the escherichia coli heme chaperone ccme to non-covalently bound heme
leukemia inhibitory factor induces dna synthesis in swiss mouse 3t3 cells independently of cyclin d1 expression through a mechanism involving mek/erk1/2 activation
efficient twin arginine translocation (tat) pathway transport of a precursor protein covalently anchored to its initial cptatc binding site
the role of human htra1 in arthritic disease
hepatic pcsk9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c
notch 1 overexpression inhibits osteoblastogenesis by suppressing wnt/-catenin but not bone morphogenetic protein signaling
the n terminus of gtps-activated transducin -subunit interacts with the c terminus of the cgmp phosphodiesterase -subunit
calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated gly-93 mutants of superoxide dismutase
importance of k+-dependent na+/ca2+-exchanger 2, nckx2, in motor learning and memory
functional characterization of the hansenula polymorpha hoc1, och1, and ocr1 genes as members of the yeast och1 mannosyltransferase family involved in protein glyco..
proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and cdk2 kinase activat..
pcna is a cofactor for cdt1 degradation by cul4/ddb1-mediated n-terminal ubiquitination
phosphorylation of serine 526 is required for mekk3 activity, and association with 14-3-3 blocks dephosphorylation
blockade of nfat activation by the second calcineurin binding site
consequences of erp57 deletion on oxidative folding of obligate and facultative clients of the calnexin cycle
yeast gtb1 encodes a subunit of glucosidase ii required for glycoprotein processing in the endoplasmic reticulum
divergent mechanisms utilized by socs3 to mediate interleukin-10 inhibition of tumor necrosis factor and nitric oxide production by macrophages
identification and characterization of an 8-kda light chain associated with dictyostelium discoideum myob, a class i myosin
transcriptional regulation of the osterix (osx, sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and nfb path..
mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in trypanosoma brucei
role of the carbohydrate binding site of the streptococcus pneumoniae capsular polysaccharide type 3 synthase in the transition from oligosaccharide to polysacchari..
activation of protein kinase c by peroxynitrite regulates lkb1-dependent amp-activated protein kinase in cultured endothelial cells
a long n-terminal-extended nested set of abundant and antigenic major histocompatibility complex class i natural ligands from hiv envelope protein
the protein phosphatase 2a phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase
a point mutation in nemo associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipo..
aifsh, a novel apoptosis-inducing factor (aif) pro-apoptotic isoform with potential pathological relevance in human cancer
genome-wide transcriptional dependence on taf1 functional domains
phosphorylation marks ipf1/pdx1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms
purification, kinetic characterization, and mapping of the minimal catalytic domain and the key polar groups of helicobacter pylori -(1,3/1,4)-fucosyltransferases
long chain base tolerance in saccharomyces cerevisiae is induced by retrograde signals from the mitochondria
hoxa1 is required for e-cadherin-dependent anchorage-independent survival of human mammary carcinoma cells
molecular mechanism of 1(i)-osteogenesis imperfecta/ehlers-danlos syndrome
membrane topology of the transporter associated with antigen processing (tap1) within an assembled functional peptide-loading complex
in vitro reconstitution of catabolite repression in escherichia coli
leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells
vangl1 protein acts as a downstream effector of intestinal trefoil factor (itf)/tff3 signaling and regulates wound healing of intestinal epithelium
structural and spectroscopic studies shed light on the mechanism of oxalate oxidase
the carboxyl terminus of the -subunit of the amiloride-sensitive epithelial sodium channel binds to f-actin
crystal structure of the human b-form low molecular weight phosphotyrosyl phosphatase at 1.6-å resolution
association of a model class a (apolipoprotein) amphipathic helical peptide with lipid
role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes
antagonistic effects of oxidized low density lipoprotein and -tocopherol on cd36 scavenger receptor expression in monocytes
carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex i in plants
histone h1 phosphorylation occurs site-specifically during interphase and mitosis
determination of the substrate specificity of tripeptidyl-peptidase i using combinatorial peptide libraries and development of improved fluorogenic substrates
aberrant folding of a mutant stat5b causes growth hormone insensitivity and proteasomal dysfunction
hexose-6-phosphate dehydrogenase knock-out mice lack 11-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation
trigger factor forms a protective shield for nascent polypeptides at the ribosome
cholesterol-regulated translocation of npc1l1 to the cell surface facilitates free cholesterol uptake
down-regulation of histone deacetylases stimulates adipocyte differentiation
pyrithiamine as a substrate for thiamine pyrophosphokinase
phosphorylation of histones by tissue transglutaminase
-latrotoxin induces exocytosis by inhibition of voltage-dependent k+ channels and by stimulation of l-type ca2+ channels via latrophilin in -cells
bopc is a novel type iii effector secreted by bordetella bronchiseptica and has a critical role in type iii-dependent necrotic cell death
annular arrangement and collaborative actions of four domains of protein-disulfide isomerase
selective permeability of different connexin channels to the second messenger cyclic amp
a critical role for calponin 2 in vascular development
probing the functional link between androgen receptor coactivator and ligand-binding sites in prostate cancer and androgen insensitivity
the structure of the interleukin-15 receptor and its implications for ligand binding
the second member of the human and murine “bubblegum“ family is a testis- and brainstem-specific acyl-coa synthetase
structure-function studies of two synthetic anti-vascular endothelial growth factor fabs and comparison with the avastintm fab
involvement of endonuclease g in nucleosomal dna fragmentation under sustained endogenous oxidative stress
cdp-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase a2 and ctp: phosphocholine cytidylyltransferase after stroke
cholesterol-induced apoptotic macrophages elicit an inflammatory response in phagocytes, which is partially attenuated by the mer receptor
ikk regulates estrogen-induced cell cycle progression by modulating e2f1 expression
group v secretory phospholipase a2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis
single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins)
ptpn11 (shp2) mutations in leopard syndrome have dominant negative, not activating, effects
the inflammatory mediator leukotriene d4 induces -catenin signaling and its association with antiapoptotic bcl-2 in intestinal epithelial cells
identification of a ubiquinone-binding site that affects autophosphorylation of the sensor kinase regb
estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms
the pyrococcus exosome complex
the molecular mechanism of peptide-mediated erythromycin resistance
ccaat enhancer-binding protein suppresses the rat placental glutathione s-transferase gene in normal liver
type i collagen abrogates the clathrin-mediated internalization of membrane type 1 matrix metalloproteinase (mt1-mmp) via the mt1-mmp hemopexin domain
equilibrium between metarhodopsin-i and metarhodopsin-ii is dependent on the conformation of the third cytoplasmic loop
n-methyl-dd-aspartate blocks activation of jnk and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells
phosphoprotein crh-ser46-p displays altered binding to ccpa to effect carbon catabolite regulation
inhibition or activation of apert syndrome fgfr2 (s252w) signaling by specific glycosaminoglycans
the house dust mite allergen der p 1, unlike der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated recepto..
phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase
plant sulfite oxidase as novel producer of h2o
the rab5 guanine nucleotide exchange factor rabex-5 binds ubiquitin (ub) and functions as a ub ligase through an atypical ub-interacting motif and a zinc finger dom..
extracellular tnfr1 release requires the calcium-dependent formation of a nucleobindin 2-arts-1 complex
atp hydrolysis is essential for the function of the uup atp-binding cassette atpase in precise excision of transposons
myospryn is a direct transcriptional target for mef2a that encodes a striated muscle, -actinin-interacting, costamere-localized protein
the effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum ca2+ atpase (serca) ca2+ pump isoforms 1, 2, and 3 ..
hydrolysis of atp by aminoglycoside 3‘-phosphotransferases
interaction of mannan binding lectin with 2 macroglobulin via exposed oligomannose glycans
activation of p21-activated kinase 2 and its association with nef are conserved in murine cells but are not sufficient to induce an aids-like disease in cd4c/hiv tr..
mitochondrial ipla2 activity modulates the release of cytochrome c from mitochondria and influences the permeability transition
construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody
the rna-binding pua domain of archaeal trna-guanine transglycosylase is not required for archaeosine formation
active conformation of the erythropoietin receptor
phlp3 modulates cct-mediated actin and tubulin folding via ternary complexes with substrates
hsp70 chaperone machine remodels protein aggregates at the initial step of hsp70-hsp100-dependent disaggregation
candida albicans spt23p controls the expression of the ole1p 9 fatty acid desaturase and regulates unsaturated fatty acid biosynthesis
the dna-binding domain of the yeast spt10p activator includes a zinc finger that is homologous to foamy virus integrase
activation of bak and bax through c-abl-protein kinase c-p38 mapk signaling in response to ionizing radiation in human non-small cell lung cancer cells
herpes simplex virus disrupts nf-b regulation by blocking its recruitment on the ib promoter and directing the factor on viral genes
effector-repressor interactions, binding of a single effector molecule to the operator-bound ttgr homodimer mediates derepression
dual roles for the phosphatase ppm1d in regulating progesterone receptor function
a functional -1 ribosomal frameshift signal in the human paraneoplastic ma3 gene
direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
a uracil-dna glycosylase inhibitor encoded by a non-uracil containing viral dna
identification of a polymeric ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric iga competition
intracellular trafficking and secretion of adiponectin is dependent on gga-coated vesicles
opposite transcriptional regulation in skeletal muscle of amp-activated protein kinase 3 r225q transgenic versus knock-out mice
smoothened regulates activator and repressor functions of hedgehog signaling via two distinct mechanisms
the vinculin binding sites of talin and -actinin are sufficient to activate vinculin
solution structure of the immunodominant domain of protective antigen gna1870 of neisseria meningitidis
murine thrombin lacks na+ activation but retains high catalytic activity
alternate recruitment of signal recognition particle and trigger factor to the signal sequence of a growing nascent polypeptide
cell cycle-dependent phosphorylation of the runx2 transcription factor by cdc2 regulates endothelial cell proliferation
fyn is required for haloperidol-induced catalepsy in mice
rotenone-like action of the branched-chain phytanic acid induces oxidative stress in mitochondria
unusual structural features of the bacteriophage-associated hyaluronate lyase (hylp2)
drosophila myosin viia is a high duty ratio motor with a unique kinetic mechanism
modulation of chaperone function and cochaperone interaction by novobiocin in the c-terminal domain of hsp9
membrane-associated stat3 and py-stat3 in the cytoplasm
trp-ml1 regulates lysosomal ph and acidic lysosomal lipid hydrolytic activity
mitochondrial and nuclear forms of wnt13 are generated via alternative promoters, alternative rna splicing, and alternative translation start sites
different mechanisms of cdk5 and cdk2 activation as revealed by cdk5/p25 and cdk2/cyclin a dynamics
endoplasmic reticulum stress-induced apoptosis
control of mitochondrial outer membrane permeabilization and bcl-xl levels by thioredoxin 2 in dt40 cells
cyclin-dependent kinase (cdk) inhibitors regulate the cdk-cyclin complex activities in endoreduplicating cells of developing tomato fruit
human arsenic methyltransferase (as3mt) pharmacogenetics
a nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to s6 kinase 1
nmr structure of the r-module
warp is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan
regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-
neutral ceramidase encoded by the asah2 gene is essential for the intestinal degradation of sphingolipids
structural and computational analysis of the quinone-binding site of complex ii (succinate-ubiquinone oxidoreductase)
prostate-derived sterile 20-like kinase 2 (psk2) regulates apoptotic morphology via c-jun n-terminal kinase and rho kinase-1
the activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod
the essential vertebrate abce1 protein interacts with eukaryotic initiation factors
nhp6 is a transcriptional initiation fidelity factor for rna polymerase iii transcription in vitro and in vivo
selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity
hyposecretion, not hyperabsorption, is the basic defect of cystic fibrosis airway glands
humanized -thalassemia mouse model containing the common ivsi-110 splicing mutation
single amino acid substitution in the pc1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme
the structure of -carbonic anhydrase from the carboxysomal shell reveals a distinct subclass with one active site for the price of two
crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-coa lyases suggest a common catalytic mechanism among a family of tim barrel metalloenzymes cleaving ..
crystal structure of human 3-hydroxy-3-methylglutaryl-coa lyase
interaction of surfactant protein a with peroxiredoxin 6 regulates phospholipase a2 activity
modulation of the transforming growth factor- signal transduction pathway by hepatitis c virus nonstructural 5a protein
ionic contacts at dnak substrate binding domain involved in the allosteric regulation of lid dynamics
phosphorylation and transactivation of pax6 by homeodomain-interacting protein kinase 2
involvement of the mouse prp19 gene in neuronal/astroglial cell fate decisions
four and a half lim protein 1 binds myosin-binding protein c and regulates myosin filament formation and sarcomere assembly
the catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (pon1) is essential for pon1-mediated inhibition of low density lipoprotein ..
the histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases
conformational changes associated with receptor-stimulated guanine nucleotide exchange in a heterotrimeric g-protein -subunit
desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies
the outer membrane protein ompw forms an eight-stranded -barrel with a hydrophobic channel
age-dependent participation of ras-grf proteins in coupling calcium-permeable ampa glutamate receptors to ras/erk signaling in cortical neurons
amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein
organelle proteomics reveals cargo maturation mechanisms associated with golgi-like encystation vesicles in the early-diverged protozoan giardia lamblia
crystal structure of a bifunctional deaminase and reductase from bacillus subtilis involved in riboflavin biosynthesis
crystal structure of human cytochrome p450 2d6
profiling of early gene expression induced by erythropoietin receptor structural variants
role of the g protein-coupled receptor kinase site serine cluster in 2-adrenergic receptor internalization, desensitization, and -arrestin translocation
the hsp70 chaperone ssq1p is dispensable for iron-sulfur cluster formation on the scaffold protein isu1p
val-407 and ile-408 in the 5‘-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles
phospholemman inhibition of the cardiac na+/ca2+ exchanger
redundancy of non-aug initiators
novel permissive role of epidermal growth factor in transforming growth factor (tgf-) signaling and growth suppression
plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility
a synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade
influence of membrane composition on osmosensing by the betaine carrier betp from corynebacterium glutamicum
interactions involved in the realignment of membrane-associated helices
protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1
up-regulation of pten (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 mapk stress signal-induced inhibition of insulin signaling
gpx2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner
phosphorylation of the hinge domain of the nuclear hormone receptor lrh-1 stimulates transactivation
insertion of the enteropathogenic escherichia coli tir virulence protein into membranes in vitro
regulation of mammalian ribonucleotide reduction and dntp pools after dna damage and in resting cells
9-o-acetylation of exogenously added ganglioside gd
heparan sulfate plays a central role in a dynamic in vitro model of protein-losing enteropathy
ig-h3 interacts directly with biglycan and decorin, promotes collagen vi aggregation, and participates in ternary complexing with these macromolecules
the brl domain in sec63p is required for assembly of functional endoplasmic reticulum translocons
secretion of the notch-1 a-like peptide during notch signaling
low conductance gap junctions mediate specific electrical coupling in body-wall muscle cells of caenorhabditis elegans
distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation
tak1 is a component of the epstein-barr virus lmp1 complex and is essential for activation of jnk but not of nf-b
gec1 interacts with the opioid receptor and enhances expression of the receptor
a pathway of structural changes produced by monastrol binding to eg5
tissue kallikrein mk13 is a candidate processing enzyme for the precursor of interleukin-1 in the submandibular gland of mice
activation of ccaat/enhancer-binding protein (c/ebp) expression by c/ebp during adipogenesis requires a peroxisome proliferator-activated receptor--associated repre..
leishmania major expresses a single dihydroxyacetone phosphate acyltransferase localized in the glycosome, important for rapid growth and survival at high cell dens..
the molecular circuitry regulating the switch between iron deficiency and overload in mice
non-cytotoxic cobra cardiotoxin a5 binds to v3 integrin and inhibits bone resorption
nucleoprotein interactions governing cell type-dependent repression of the mouse smooth muscle -actin promoter by single-stranded dna-binding proteins pur and pur
regulation of neuroendocrine exocytosis by the arf6 gtpase-activating protein git1
jab1, a novel protease-activated receptor-2 (par-2)-interacting protein, is involved in par-2-induced activation of activator protein-1
requirement of the protein b23 for nucleolar disassembly induced by the frgy2a family proteins
enhanced 1 microglobulin secretion from hepatitis e virus orf3-expressing human hepatoma cells is mediated by the tumor susceptibility gene 101
the growth and tumor suppressor nore1a is a cytoskeletal protein that suppresses growth by inhibition of the erk pathway
gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly
the cytotoxic lymphocyte protease, granzyme b, targets the cytoskeleton and perturbs microtubule polymerization dynamics
the gtp-binding protein ylqf participates in the late step of 50 s ribosomal subunit assembly in bacillus subtilis
expression profiling of a hypercontraction-induced myopathy in drosophila suggests a compensatory cytoskeletal remodeling response
genome-wide transcriptional profile of escherichia coli in response to high levels of the second messenger 3‘,5‘-cyclic diguanylic acid
identification of morphine-6-glucuronide in chromaffin cell secretory granules
common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and 42 nicotinic acetylcholine receptors
the pnra (tp0319; tmpc) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an atp-binding cassette (abc)-like operon in trep..
mutation of a conserved threonine in the third transmembrane helix of - and -connexins creates a dominant-negative closed gap junction channel
conformation-assisted inhibition of protein-tyrosine phosphatase-1b elicits inhibitor selectivity over t-cell protein-tyrosine phosphatase
fibrillins 1 and 2 perform partially overlapping functions during aortic development
latent pathway activation and increased pathway capacity enable escherichia coli adaptation to loss of key metabolic enzymes
a chondroitin sulfate chain attached to the bone dentin matrix protein 1 nh2-terminal fragment
identification of myxomaviral serpin reactive site loop sequences that regulate innate immune responses
conformational flexibility of mammalian cytochrome p450 2b4 in binding imidazole inhibitors with different ring chemistry and side chains
sumo-1 controls the protein stability and the biological function of phosducin
identification of the mste gene encoding a glucose-inducible, low affinity glucose transporter in aspergillus nidulans
hiv-1 tat is a natively unfolded protein
endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor
regulation of protein kinase c by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes
apobec3 cytidine deaminases: distinct antiviral actions along the retroviral life cycle
tsc1 stabilizes tsc2 by inhibiting the interaction between tsc2 and the herc1 ubiquitin ligase
direct stimulation of transcription initiation by brca1 requires both its amino and carboxyl termini
structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins
the bacillus subtilis ykuv is a thiol:disulfide oxidoreductase revealed by its redox structures and activity
role of early growth response-1 (egr-1) in interleukin-13-induced inflammation and remodeling
self-association and chaperone activity of hsp27 are thermally activated
versican g3 domain promotes blood coagulation through suppressing the activity of tissue factor pathway inhibitor-1
docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase, c-terminal src kinase (csk)
role of n-terminal familial mutations in prion protein fibrillization and prion amyloid propagation in vitro
regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide
mutations conferring resistance to sch6, a novel hepatitis c virus ns3/4a protease inhibitor
enhancement of streptolysin o activity and intrinsic cytotoxic effects of the group a streptococcal toxin, nad-glycohydrolase
-subunit confers novel biophysical features to -human epithelial sodium channel (enac) via a physical interaction
the amphoterin (hmgb1)/receptor for advanced glycation end products (rage) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness
molecular cloning and characterization of udp-glucose dehydrogenase from the amphibian xenopus laevis and its involvement in hyaluronan synthesis
assembly of a polymeric chain of sumo1 on human topoisomerase i in vitro
variable reactivity of an engineered cysteine at position 338 in cystic fibrosis transmembrane conductance regulator reflects different chemical states of the thiol
the kinetic mechanism of the sufc atpase
substrate preferences of the ezh2 histone methyltransferase complex
novel carbohydrate-binding activity of pancreatic trypsins to n-linked glycans of glycoproteins
regions of the catalytic subunit of na,k-atpase important for functional interactions with fxyd 2
regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
dual role for transactivator protein c in activation of mom promoter of bacteriophage mu
integrin 2-mediated erk and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling
agmatine stimulates hepatic fatty acid oxidation
histone h3 lysine 9 methyltransferase g9a is a transcriptional coactivator for nuclear receptors
interaction between eukaryotic initiation factors 1a and 5b is required for efficient ribosomal subunit joining
differentiation of carbazole catabolic operons by replacement of the regulated promoter via transposition of an insertion sequence
oncostatin m receptor-mediated signal transduction is negatively regulated by socs3 through a receptor tyrosine-independent mechanism
src-dependent aprotein kinase c / (apkc/) tyrosine phosphorylation is required for apkc/ association with rab2 and glyceraldehyde-3-phosphate dehydrogenase on pre-g..
relationship between udp-galactose 4‘-epimerase activity and galactose sensitivity in yeast
regulation of lipid metabolism genes, lipid carrier protein lipophorin, and its receptor during immune challenge in the mosquito aedes aegypti
regulation of g protein-coupled receptor trafficking by inefficient plasma membrane expression
cyclic gmp-dependent protein kinase i inhibits thrombin receptor-mediated calcium mobilization in vascular smooth muscle cells
the dna binding activity of mutl is required for methyl-directed mismatch repair in escherichia coli
synapsin i is a major endogenous substrate for protein l-isoaspartyl methyltransferase in mammalian brain
protein kinase c-rhoa cross-talk in ccl2-induced alterations in brain endothelial permeability
pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways
catalytic mechanism of class b2 metallo--lactamase
loss of pecam-1 function impairs alveolarization
hip3 interacts with the hira proteins hip1 and slm9 and is required for transcriptional silencing and accurate chromosome segregation
loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction
p19ras interacts with and activates p73 by involving the mdm2 protein
site-directed mutations of t4 helicase loading protein (gp59) reveal multiple modes of dna polymerase inhibition and the mechanism of unlocking by gp41 helicase
antianoikis effect of nuclear factor-b through up-regulated expression of osteoprotegerin, bcl-2, and iap-1
structure and activation mechanism of the drosophila initiator caspase dronc
dna damage-induced expression of p53 suppresses mitotic checkpoint kinase hmps
calcium-induced acrosomal exocytosis requires camp acting through a protein kinase a-independent, epac-mediated pathway
the novel wd-repeat protein morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (phd3)
the viral e3 ubiquitin ligase mk3 uses the derlin/p97 endoplasmic reticulum-associated degradation pathway to mediate down-regulation of major histocompatibility co..
function and solution structure of huwentoxin-x, a specific blocker of n-type calcium channels, from the chinese bird spider ornithoctonus huwena
dynamic association between the catalytic and lectin domains of human udp-galnac:polypeptide -n-acetylgalactosaminyltransferase-2
leucine motif-dependent tyrosine autophosphorylation of type iii receptor tyrosine kinases
dapper 1 antagonizes wnt signaling by promoting dishevelled degradation
wt p53, but not tumor-derived mutants, bind to bcl2 via the dna binding domain and induce mitochondrial permeabilization
parkin suppresses the expression of monoamine oxidases
stress activation of mammary epithelial cell xanthine oxidoreductase is mediated by p38 mapk and ccaat/enhancer-binding protein-
tumor necrosis factor receptor (tnfr)-associated factor 5 is a critical intermediate of costimulatory signaling pathways triggered by glucocorticoid-induced tnfr in..
nfb signaling is induced by the oncoprotein tio through direct interaction with traf6
chromophore attachment to phycobiliprotein -subunits
importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate
solution structure of a post-transition state analog of the phosphotransfer reaction between the a and b cytoplasmic domains of the mannitol transporter iimannitol ..
role for akt/protein kinase b and activator protein-1 in cellular proliferation induced by the human t-cell leukemia virus type 1 tax oncoprotein
dynamics of the ras/erk mapk cascade as monitored by fluorescent probes
structural and functional characterization of psec, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in hel..
the structure of the mammalian signal recognition particle (srp) receptor as prototype for the interaction of small gtpases with longin domains
dynamic changes in histone h3 lysine 9 methylations
in vivo regulation of grp78/bip transcription in the embryonic heart
self-association and lipid binding properties of the lipoprotein initiating domain of apolipoprotein b
activation of family c g-protein-coupled receptors by the tripeptide glutathione
subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4b
effects of coumarate 3-hydroxylase down-regulation on lignin structure
opposite effects of rho family gtpases on engulfment of apoptotic cells by macrophages
dissociation of recruitment and activation of the small g-protein rac during fc receptor-mediated phagocytosis
contact inhibition of hepatocyte growth regulated by functional association of the c-met/hepatocyte growth factor receptor and lar protein-tyrosine phosphatase
role of hirudin-like factor va heavy chain sequences in prothrombinase function
structural model for the mannose receptor family uncovered by electron microscopy of endo180 and the mannose receptor
poly(adp-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires rip1/traf2-mediated jnk1 activation
the affinity of a major ca2+ binding site on grp78 is differentially enhanced by adp and atp
syk tyrosine kinase mediates epstein-barr virus latent membrane protein 2a-induced cell migration in epithelial cells
xyloglucan is recognized by carbohydrate-binding modules that interact with -glucan chains
a growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer
dissection of the interaction of the human cytomegalovirus-derived us2 protein with major histocompatibility complex class i molecules
cpsufe activates the cysteine desulfurase cpnifs for chloroplastic fe-s cluster formation
subclassification of the rbcc/trim superfamily reveals a novel motif necessary for microtubule binding
crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis
polyamines are potent ligands for the capsaicin receptor trpv1
cytochrome p-450 4f18 is the leukotriene b4 -1/-2 hydroxylase in mouse polymorphonuclear leukocytes
atgat1, a high affinity transporter for -aminobutyric acid in arabidopsis thaliana
functions of the cytoplasmic tails of the human receptor activity-modifying protein components of calcitonin gene-related peptide and adrenomedullin receptors
accelerated lipid absorption in mice overexpressing intestinal sr-bi
protein interaction analysis of st14 domains and their point and deletion mutants
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