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a unified view of the role of electrostatic interactions in modulating the gating of cys loop receptors
structural basis for activation of the thiamin diphosphate-dependent enzyme oxalyl-coa decarboxylase by adenosine diphosphate
distinct roles for scl in erythroid specification and maturation in zebrafish
endocytosis resumes during late mitosis and is required for cytokinesis
ubiquitylation and degradation of serum-inducible kinase by hvps18, a ring-h2 type ubiquitin ligase
human centromere protein b induces translational positioning of nucleosomes on -satellite sequences
a prohormone convertase cleavage site within a predicted -helix mediates sorting of the neuronal and endocrine polypeptide vgf into the regulated secretory pathway
mva1269i: a monomeric type iis restriction endonuclease from micrococcus varians with two ecori- and foki-like catalytic domains
the two thrombospondin type i repeat domains of the heparin-binding growth-associated molecule bind to heparin/heparan sulfate and regulate neurite extension and pl..
evidence for direct roles of two additional factors, secp43 and soluble liver antigen, in the selenoprotein synthesis machinery
biochemical and motile properties of myo1b splice isoforms
structural basis of antigen mimicry in a clinically relevant melanoma antigen system
human kruppel-like factor 5 is a target of the e3 ubiquitin ligase wwp1 for proteolysis in epithelial cells
the c-terminal rpon domain of 54 forms an unpredicted helix-turn-helix motif similar to domains of 70
p300 modulates atf4 stability and transcriptional activity independently of its acetyltransferase domain
s100a8 and s100a9 in human arterial wall
production of recombinant human trimeric cd137l (4-1bbl)
the structure of human sult1a1 crystallized with estradiol
diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of -tubulin
novel antibody hinge regions for efficient production of ch2 domain-deleted antibodies
does amp-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in o2-sensing cells?
the cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2a
human but not yeast chd1 binds directly and selectively to histone h3 methylated at lysine 4 via its tandem chromodomains
effects of hmgn1 on chromatin structure and swi/snf-mediated chromatin remodeling
g binds histone deacetylase 5 (hdac5) and inhibits its transcriptional co-repression activity
mass spectrometric and kinetic analysis of asf/sf2 phosphorylation by srpk1 and clk/sty
a ph-dependent molten globule transition is required for activity of the steroidogenic acute regulatory protein, star
slam-associated protein as a potential negative regulator in trk signaling
hypoxia-inducible factor prolyl 4-hydroxylase inhibition
cpg-binding protein (cxxc finger protein 1) is a component of the mammalian set1 histone h3-lys4 methyltransferase complex, the analogue of the yeast set1/compass c..
structures of the mthk rck domain and the effect of ca2+ on gating ring stability
structural basis for stable dna complex formation by the caspase-activated dnase
functional characterization of 2‘,5‘-linked oligoadenylate binding determinant of human rnase l
identification of an alternatively spliced variant of ca2+-promoted ras inactivator as a possible regulator of rankl shedding
tyrosine phosphorylation of kir3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress
structure and substrate specificity of the pim-1 kinase
l55p transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers
reversible inactivation of hif-1 prolyl hydroxylases allows cell metabolism to control basal hif-1
4-hydroxynonenal induces adaptive response and enhances pc12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of nrf2
dmi-2 chromatin binding and remodeling activities are regulated by dck2 phosphorylation
detection of oligomerization and conformational changes in the na+/h+ antiporter from helicobacter pylori by fluorescence resonance energy transfer
jak1 and tyk2 activation by the homologous polycythemia vera jak2 v617f mutation
the transcriptional response of saccharomyces cerevisiae to pichia membranifaciens killer toxin
transient state kinetics of enzyme iicbglc, a glucose transporter of the phosphoenolpyruvate phosphotransferase system of escherichia coli
regulation of l-type ca2+ channel activity and insulin secretion by the rem2 gtpase
the conserved leu-724 residue is required for both serine phosphorylation and co-activator recruitment for stat1-mediated transcription activation in response to in..
biochemical and mutational analyses of a unique clamp loader complex in the archaeon methanosarcina acetivorans
inhibition of acetyl-coa carboxylase isoforms by pyridoxal phosphate
an unusual, his-dependent family i pyrophosphatase from mycobacterium tuberculosis
nf-b protects macrophages from lipopolysaccharide-induced cell death
functional characterization of complement proteases c1s/mannan-binding lectin-associated serine protease-2 (masp-2) chimeras reveals the higher c4 recognition effic..
genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis
a membrane-bound multienzyme, hydrogen-oxidizing, and sulfur-reducing complex from the hyperthermophilic bacterium aquifex aeolicus
state-dependent chemical reactivity of an engineered cysteine reveals conformational changes in the outer vestibule of the cystic fibrosis transmembrane conductance..
-secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site
temperature-sensitive mutant of the caenorhabditis elegans neurotoxic mec-4(d) deg/enac channel identifies a site required for trafficking or surface maintenance
pen-2 is incorporated into the -secretase complex through binding to transmembrane domain 4 of presenilin 1
evidence that the “nf“ motif in transmembrane domain 4 of presenilin 1 is critical for binding with pen-2
a novel anti-human dr5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death
novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay
aspirin induces platelet receptor shedding via adam17 (tace)
transactivation of cxcr4 by the insulin-like growth factor-1 receptor (igf-1r) in human mda-mb-231 breast cancer epithelial cells
prib stimulates pria helicase via an interaction with single-stranded dna
an anti-inflammatory function for the complement anaphylatoxin c5a-binding protein, c5l2
a role for hypothalamic malonyl-coa in the control of food intake
error-prone translesion synthesis by human dna polymerase on dna-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzopyrene
rapid b cell receptor-induced unfolded protein response in nonsecretory b cells correlates with pro- versus antiapoptotic cell fate
human mismatch repair
physiological and pathological changes in glucose regulate brain akt and glycogen synthase kinase-3
characterization of peroxy-a2e and furan-a2e photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin
cdk phosphorylation inhibits the dna-binding and atp-hydrolysis activities of the drosophila origin recognition complex
enzymatically active adamts13 variants are not inhibited by anti-adamts13 autoantibodies
intracellular lipidation of newly synthesized apolipoprotein a-i in primary murine hepatocytes
dissociation of emerin from barrier-to-autointegration factor is regulated through mitotic phosphorylation of emerin in a xenopus egg cell-free system
the caterpiller protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor -, and mycobacterium tuberculosis-induced pro-inflammatory signals
proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis
effects of spontaneous deamidation on the cytotoxic activity of the bacillus anthracis protective antigen
transport activity of mct1 expressed in xenopus oocytes is increased by interaction with carbonic anhydrase
sources of nadph in yeast vary with carbon source
identification and characterization of a novel human type ii diacylglycerol kinase, dgk
the sequence at specific positions in the early transcribed region sets the rate of transcript synthesis by rna polymerase ii in vitro
spermine oxidase smo(paoh1), not n1-acetylpolyamine oxidase pao, is the primary source of cytotoxic h2o2 in polyamine analogue-treated human breast cancer cell lines
cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes
glycosylphosphatidylinositol-anchored fungal polysaccharide in aspergillus fumigatus
nuclear factor 1 family members interact with hepatocyte nuclear factor 1 to synergistically activate l-type pyruvate kinase gene transcription
prohormone-convertase 1 processing enhances post-golgi sorting of prothyrotropin-releasing hormone-derived peptides
the monocarboxylate transporter homolog mch5p catalyzes riboflavin (vitamin b2) uptake in saccharomyces cerevisiae
hepatitis c virus nonstructural proteins inhibit apolipoprotein b100 secretion
tis7 regulation of the -catenin/tcf-4 target gene osteopontin (opn) is histone deacetylase-dependent
role of endogenous trpc6 channels in ca2+ signal generation in a7r5 smooth muscle cells
reassembly of active caspase-3 is facilitated by the propeptide
small ubiquitin-like modifier (sumo) recognition of a sumo binding motif
mechanism of hairpin-duplex conversion for the hiv-1 dimerization initiation site
a flagellum-specific calcium sensor
the inv(16) cooperates with arf haploinsufficiency to induce acute myeloid leukemia
endogenous thioredoxin is required for redox cycling of anthracyclines and p53-dependent apoptosis in cancer cells
role of the lid hydrophobicity pattern in pancreatic lipase activity
hsulf-1 and hsulf-2 are potent inhibitors of myeloma tumor growth in vivo
structural basis for the specificity and catalysis of human atg4b responsible for mammalian autophagy
accommodation and repair of a uv photoproduct in dna at different rotational settings on the nucleosome surface
heat shock protein 40 is necessary for human immunodeficiency virus-1 nef-mediated enhancement of viral gene expression and replication
regulation of the interaction of pak2 with cdc42 via autophosphorylation of serine 141
disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects
binding of the intracellular fas ligand (fasl) domain to the adaptor protein pstpip results in a cytoplasmic localization of fasl
substrate specificity and activity regulation of protein kinase melk
extracellular domain nicotinic acetylcholine receptors formed by 4 and 2 subunits
ddb1-ddb2 (xeroderma pigmentosum group e) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions i..
elevated levels of the 64-kda cleavage stimulatory factor (cstf-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative po..
geldanamycin induces heat shock protein 70 and protects against mptp-induced dopaminergic neurotoxicity in mice
a novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport
a role for erbin in the regulation of nod2-dependent nf-b signaling
naturally occurring capsid substitutions render hiv-1 cyclophilin a independent in human cells and trim-cyclophilin-resistant in owl monkey cells
hdac6 and microtubules are required for autophagic degradation of aggregated huntingtin
structural studies on a mitochondrial glyoxalase ii
arachidonic acid inhibits the insulin induction of glucose-6-phosphate dehydrogenase via p38 map kinase
peroxisome proliferator-activated receptor suppresses proximal 1(i) collagen promoter via inhibition of p300-facilitated nf-i binding to dna in hepatic stellate cells
protein kinase c- regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3
determination of peptide substrate specificity for µ-calpain by a peptide library-based approach
the disintegrin adam9 indirectly contributes to the physiological processing of cellular prion by modulating adam10 activity
molecular characterization of the gerbil c5a receptor and identification of a transmembrane domain v amino acid that is crucial for small molecule antagonist intera..
phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase
molecular determinants of kinase pathway activation by apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
the vitamin d receptor, runx2, and the notch signaling pathway cooperate in the transcriptional regulation of osteopontin
stabilization of basally translated nf-b-inducing kinase (nik) protein functions as a molecular switch of processing of nf-b2 p100
electron paramagnetic resonance analysis of nitrosylhemoglobin in humans during no inhalation
chromosomal instability induced by pim-1 is passage-dependent and associated with dysregulation of cyclin b1
the pso4 mrna splicing and dna repair complex interacts with wrn for processing of dna interstrand cross-links
repair of formamidopyrimidines in dna involves different glycosylases
pre-steady-state kinetic characterization of the dinb homologue dna polymerase of sulfolobus solfataricus
evidence that hiv-1 reverse transcriptase employs the dna 3‘ end-directed primary/secondary rnase h cleavage mechanism during synthesis and strand transfer
oxidant-specific folding of yap1p regulates both transcriptional activation and nuclear localization
extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1 expression in human monocyte-derived macrophages
analysis of coumarin 7-hydroxylation activity of cytochrome p450 2a6 using random mutagenesis
structural and functional evidence for bacillus subtilis paia as a novel n1-spermidine/spermine acetyltransferase
a transgenic mouse model of heart failure using inducible gq
gq inhibits cardiac l-type ca2+ channels through phosphatidylinositol 3-kinase
mechanisms of plakoglobin-dependent adhesion
sirt1 protects against microglia-dependent amyloid- toxicity through inhibiting nf-b signaling
characterization of archaeal group ii chaperonin-adp-metal fluoride complexes
mitochondrial cyclic amp response element-binding protein (creb) mediates mitochondrial gene expression and neuronal survival
c-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (htert) promoter
mtor·rictor is the ser473 kinase for akt/protein kinase b in 3t3-l1 adipocytes
absence of nucleoside diphosphatase activities in the yeast secretory pathway does not abolish nucleotide sugar-dependent protein glycosylation
hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin a..
calmodulin is involved in the ca2+-dependent activation of ceramide kinase as a calcium sensor
psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase c-dependent mechanisms
acetylation of poly(adp-ribose) polymerase-1 by p300/creb-binding protein regulates coactivation of nf-b-dependent transcription
discovery and characterization of the cryptic subunit of the pseudomonad dna replicase
functions of early (ap-2) and late (aip1/alix) endocytic proteins in equine infectious anemia virus budding
subunit a of the yeast v-atpase participates in binding of bafilomycin
mapping the interaction of the stt3 subunit of the oligosaccharyl transferase complex with nascent polypeptide chains
low energy pathways and non-native interactions
the arac-type regulator ripa represses aconitase and other iron proteins from corynebacterium under iron limitation and is itself repressed by dtxr
overproduction of chains provides a proton-insensitive component to the bluefish hemoglobin system
multifunctional roles of the conserved arg residues in the second region of homology of p97/valosin-containing protein
an aberrant sequence in a connexin46 mutant underlies congenital cataracts
sumoylation and acetylation play opposite roles in the transactivation of plag1 and plagl2
structure of the unphosphorylated stat5a dimer
individual phosphoinositide 3-kinase c2 domain activities independently regulate clathrin function
functional interaction between the drosophila knirps short range transcriptional repressor and rpd3 histone deacetylase
procainamide is a specific inhibitor of dna methyltransferase 1
identification and characterization of keyhole limpet hemocyanin n-glycans mediating cross-reactivity with schistosoma mansoni
the nanomechanics of polycystin-1 extracellular region
cdna cloning and functional expression of jerdostatin, a novel rts-disintegrin from trimeresurus jerdonii and a specific antagonist of the 11 integrin
extended upstream a-t sequence increases t7 promoter strength
p-hydroxybenzoic acid synthesis in mycobacterium tuberculosis
intramolecular electron transfer between tyrosyl radical and cysteine residue inhibits tyrosine nitration and induces thiyl radical formation in model peptides trea..
identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the g protein-coupled receptor g2a
regulation of ck2 activity by phosphatidylinositol phosphates
pseudomonas aeruginosa ld-carboxypeptidase, a serine peptidase with a ser-his-glu triad and a nucleophilic elbow
transducin activation state controls its light-dependent translocation in rod photoreceptors
expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein
peroxisomal proliferation protects from -amyloid neurodegeneration
pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating bcl-2 gene expression
single molecule adhesion measurements reveal two homophilic neural cell adhesion molecule bonds with mechanically distinct properties
the camp pathway regulates both transcription and activity of the paired homeobox transcription factor phox2a required for development of neural crest-derived and c..
carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in hiv gp12
active site residues and amino acid specificity of the ubiquitin carrier protein-binding ring-h2 finger domain
the modular adaptor protein autosomal recessive hypercholesterolemia (arh) promotes low density lipoprotein receptor clustering into clathrin-coated pits
the lysosome-associated apoptosis-inducing protein containing the pleckstrin homology (ph) and fyve domains (lapf), representative of a novel family of ph and fyve ..
calcium ion promotes yeast dmc1 activity via formation of long and fine helical filaments with single-stranded dna
neutron scattering reveals the dynamic basis of protein adaptation to extreme temperature
3-phosphoinositide-dependent protein kinase-1-mediated ib kinase (ikkb) phosphorylation activates nf-b signaling
computer-assisted docking of flavodoxin with the atp:co(i)rrinoid adenosyltransferase (coba) enzyme reveals residues critical for protein-protein interactions but n..
fluorescent, acyl chain-labeled phosphatidylcholine analogs reveal novel transport pathways across the plasma membrane of yeast
absence of a detectable intermediate in the compound i formation of horseradish peroxidase at ambient temperature
tropoelastin interacts with cell-surface glycosaminoglycans via its cooh-terminal domain
regulation of nad(p)h oxidase by associated protein disulfide isomerase in vascular smooth muscle cells
isolation of a calmodulin-binding transcription factor from rice (oryza sativa l.)
activation of the src family kinase hck without sh3-linker release
roles of the n-domains of the clpa unfoldase in binding substrate proteins and in stable complex formation with the clpp protease
characterization of a novel filarial serine protease inhibitor, ov-spi-1, from onchocerca volvulus, with potential multifunctional roles during development of the p..
sp1 is a co-activator with ets-1, and net is an important repressor of the transcription of ctp:phosphocholine cytidylyltransferase
endothelin-converting enzyme-1, abundance of isoforms a-d and identification of a novel alternatively spliced variant lacking a transmembrane domain
crystal structures of 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase belonging to a new family of nad(p)h-dependent oxidoreductases
phosphatidylinositol 3,4,5-trisphosphate mediates aldosterone stimulation of epithelial sodium channel (enac) and interacts with -enac
the type iii inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic ca2+ signals into mitochondria
importin 4 is responsible for ligand-independent nuclear translocation of vitamin d receptor
polymorphism and double hexamer structure in the archaeal minichromosome maintenance (mcm) helicase from methanobacterium thermoautotrophicum
cell-specific regulation of androgen receptor phosphorylation in vivo
na+/h+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (cftr) expression and activity in human ai..
catalase plays a critical role in the csf-independent survival of human macrophages via regulation of the expression of bcl-2 family
all four putative selectivity filter glycine residues in ktrb are essential for high affinity and selective k+ uptake by the ktrab system from vibrio alginolyticus
clotrimazole inhibits hemoperoxidase of plasmodium falciparum and induces oxidative stress
the tumor suppressor cylindromatosis (cyld) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with traf6 and traf7
structure of human phytanoyl-coa 2-hydroxylase identifies molecular mechanisms of refsum disease
expansion of substrate specificity of cytochrome p450 2a6 by random and site-directed mutagenesis
fln29, a novel interferon- and lps-inducible gene acting as a negative regulator of toll-like receptor signaling
structural and hemostatic activities of a sulfated galactofucan from the brown alga spatoglossum schroederi
ynd1 interacts with cdc55 and is a novel mediator of e4orf4-induced toxicity
the yeast hsp110 sse1 functionally interacts with the hsp70 chaperones ssa and ssb
light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells
pak4 functions in tumor necrosis factor (tnf) -induced survival pathways by facilitating tradd binding to the tnf receptor
processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth
a mammalian chromatin remodeling complex with similarities to the yeast ino80 complex
inflammatory cytokines induce production of chi3l1 by articular chondrocytes
gene-specific changes in promoter occupancy by thyroid hormone receptor during frog metamorphosis
biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2
flhb regulates ordered export of flagellar components via autocleavage mechanism
hsp110 cooperates with different cytosolic hsp70 systems in a pathway for de novo folding
liver x receptor interferes with srebp1c-mediated abcd2 expression
identification of six novel allosteric effectors of arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms
the thylakoid ph/ are not required for the initial stages of tat-dependent protein transport in tobacco protoplasts
diacylglycerol induces fusion of nuclear envelope membrane precursor vesicles
functional dissection of osteoprotegerin and its interaction with receptor activator of nf-b ligand
three-dimensional solution structures of the chromodomains of cpsrp43
structural evidence for non-canonical binding of ca2+ to a canonical ef-hand of a conventional myosin
conjugation of lg domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering
blocking tumor cell migration and invasion with biphenyl isoxazole derivative kribb3, a synthetic molecule that inhibits hsp27 phosphorylation
the highly abundant protein ag-lbp55 from ascaridia galli represents a novel type of lipid-binding proteins
conserved ets domain arginines mediate dna binding, nuclear localization, and a novel mode of bzip interaction
an axonemal dynein particularly important for flagellar movement at high viscosity
specific enhancement of sk channel activity selectively potentiates the afterhyperpolarizing current iahp and modulates the firing properties of hippocampal pyramid..
isolation of monomeric human vhs by a phage selection
silencing of the meiotic genes smc1 and stag3 in somatic cells by e2f6
the osmotic activation of transporter prop is tuned by both its c-terminal coiled-coil and osmotically induced changes in phospholipid composition
activation of cuzn superoxide dismutases from caenorhabditis elegans does not require the copper chaperone ccs
human histone demethylase lsd1 reads the histone code
the structural and functional role of med5 in the yeast mediator tail module
thrombin-activable factor x re-establishes an intrinsic amplification in tenase-deficient plasmas
wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by -catenin-dependent and -independent signaling cascades i..
atpase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in walker a motif
differential contribution of troponin i phosphorylation sites to the endothelin-modulated contractile response
stability domains, substrate-induced conformational changes, and hinge-bending motions in a psychrophilic phosphoglycerate kinase
rna polymerase holoenzymes can share a single transcription start site for the pm promoter
polycystin 2 interacts with type i inositol 1,4,5-trisphosphate receptor to modulate intracellular ca2+ signaling
regulation of fatty acid synthesis by farnesyl pyrophosphate
uv irradiation and desiccation modulate the three-dimensional extracellular matrix of nostoc commune (cyanobacteria)
structure of the bundle-forming pilus from enteropathogenic escherichia coli
btk plays a crucial role in the amplification of fcri-mediated mast cell activation by kit
altered exon usage in the juxtamembrane domain of mouse and human ron regulates receptor activity and signaling specificity
direct observation of protein folding, aggregation, and a prion-like conformational conversion
disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin a deficiency
homo- and hetero-oligomerization of -arrestins in living cells
oligomerization state of the dna fragmentation factor in normal and apoptotic cells
ataxia-telangiectasia-mutated (atm) is a t-antigen kinase that controls sv40 viral replication in vivo
identification of a novel extracellular cation-sensing g-protein-coupled receptor
structural basis for a functional antagonist in the transforming growth factor superfamily
distinct protein classes including novel merozoite surface antigens in raft-like membranes of plasmodium falciparum
the roles of two clip domain serine proteases in innate immune responses of the malaria vector anopheles gambiae
nuclear import of the retinoid x receptor, the vitamin d receptor, and their mutual heterodimer
inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization
real-time monitoring of conformational dynamics of the subunit in f1-atpase
the dnaj-domain protein rme-8 functions in endosomal trafficking
discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen
resistin-like molecule activates mapks, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a h..
rotenone model of parkinson disease
acute physical stress elevates mouse period1 mrna expression in mouse peripheral tissues via a glucocorticoid-responsive element
nitric oxide negatively regulates fas cd95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of flice inhibitory protein
characterization of an erk-binding domain in microphthalmia-associated transcription factor and differential inhibition of erk2-mediated substrate phosphorylation
kinetics and template nucleation of self-assembled hydroxyapatite nanocrystallites by chondroitin sulfate
the smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor
gpx2, encoding a phospholipid hydroperoxide glutathione peroxidase homologue, codes for an atypical 2-cys peroxiredoxin in saccharomyces cerevisiae
defective tumor necrosis factor--dependent control of astrocyte glutamate release in a transgenic mouse model of alzheimer disease
the survival kinase mirk/dyrk1b is activated through rac1-mkk3 signaling
the rna binding g-patch domain in retroviral protease is important for infectivity and d-type morphogenesis of mason-pfizer monkey virus
the transcription factors ap-1 and ets are regulators of c3a receptor expression
losa, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from mycobacterium marinum
direct observation of a novel perturbed oxyferrous catalytic intermediate during reduced putidaredoxin-initiated turnover of cytochrome p-450-cam
nutritional status, cognition, and survival
inhibition of hiv-1 maturation via drug association with the viral gag protein in immature hiv-1 particles
calcium binding by the essential virulence factor bad-1 of blastomyces dermatitidis
tumor suppressor in lung cancer (tslc)1 suppresses epithelial cell scattering and tubulogenesis
nitrosylation of human glutathione transferase p1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo
heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia
role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome p450 158a
mechanisms of cell-surface rerouting of an endoplasmic reticulum-retained mutant of the vasopressin v1b/v3 receptor by a pharmacological chaperone
two-dimensional kinetics regulation of l2-icam-1 interaction by conformational changes of the l-inserted domain
phosphorylation of wasp by the cdc42-associated kinase ack
proteomic analysis of srm160-containing complexes reveals a conserved association with cohesin
centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice
g12/13 is essential for directed cell migration and localized rho-dia1 function
binding of barrier to autointegration factor (baf) to histone h3 and selected linker histones including h1.1
lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle
cooperative dimerization of fibroblast growth factor 1 (fgf1) upon a single heparin saccharide may drive the formation of 2:2:1 fgf1·fgfr2c·heparin ternary comple..
ileal bile acid-binding protein, functionally associated with the farnesoid x receptor or the ileal bile acid transporter, regulates bile acid activity in the small..
death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia
disruption of microtubules ablates the specificity of insulin signaling to glut4 translocation in 3t3-l1 adipocytes
directed evolution of a ring-cleaving dioxygenase for polychlorinated biphenyl degradation
the crystal structure of mitochondrial (type 1a) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms
regulated localization of rab18 to lipid droplets
tetanus toxin is transported in a novel neuronal compartment characterized by a specialized ph regulation
proinsulin is refractory to protein fibrillation
structure and function of the xpse n-terminal domain, an essential component of the xanthomonas campestris type ii secretion system
role of 14-3-3 in fe65-dependent gene transactivation mediated by the amyloid -protein precursor cytoplasmic fragment
epha2 phosphorylates the cytoplasmic tail of claudin-4 and mediates paracellular permeability
the ste20-like kinase slk is required for cell cycle progression through g2
novel conformational states of peptide deformylase from pathogenic bacterium leptospira interrogans
proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (clic4) in tub..
double hexamer disruption and biochemical activities of methanobacterium thermoautotrophicum mcm
role of the main access channel of catalase-peroxidase in catalysis
analysis of rova, a transcriptional regulator of yersinia pseudotuberculosis virulence that acts through antirepression and direct transcriptional activation
regulation of the ink4a/arf locus by histone deacetylase inhibitors
h2-calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton
lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in o-fucosylated epidermal growth factor-like repeats
fatty acid transduction of nitric oxide signaling
structural basis for membrane anchorage of viral 29 dna during replication
sequences required for the activity of ptox (immutans), a plastid terminal oxidase
tumor suppressor p53 binds with high affinity to ctg·cag trinucleotide repeats and induces topological alterations in mismatched duplexes
high resolution 1h nmr-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of batten disease
solution structure of the human immunodeficiency virus type 1 p6 protein
retrograde response to mitochondrial dysfunction is separable from tor1/2 regulation of retrograde gene expression
hsk1-dfp1/him1, the cdc7-dbf4 kinase in schizosaccharomyces pombe, associates with swi1, a component of the replication fork protection complex
m-rip targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells
raf60, a novel component of the rpd3 histone deacetylase complex required for rpd3 activity in saccharomyces cerevisiae
synthetic vpr protein activates activator protein-1, c-jun n-terminal kinase, and nf-b and stimulates hiv-1 transcription in promonocytic cells and primary macropha..
p53 monitors replication fork regression by binding to “chickenfoot“ intermediates
transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4
calcium triggers folding of lipoprotein lipase into active dimers
role of histone modifications in marking and activating genes through mitosis
hemextin ab complex, a unique anticoagulant protein complex from hemachatus haemachatus (african ringhals cobra) venom that inhibits clot initiation and factor viia..
substrate recognition by the human fatty-acid synthase
human serum from patients with septic shock activates transcription factors stat1, irf1, and nf-b and induces apoptosis in human cardiac myocytes
the saccharomyces cerevisiae coq10 gene encodes a start domain protein required for function of coenzyme q in respiration
a novel type of detergent-resistant membranes may contribute to an early protein sorting event in epithelial cells
positive regulation of raf1-mek1/2-erk1/2 signaling by protein serine/threonine phosphatase 2a holoenzymes
similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of -synuclein, parkin, and dj-1 in caenorhabditis elegans
early events in the fibrillation of monomeric insulin
oxygen tension regulates mitochondrial dna-encoded complex i gene expression
wnk1 regulates phosphorylation of cation-chloride-coupled cotransporters via the ste20-related kinases, spak and osr1
receptor-type protein-tyrosine phosphatase- regulates epidermal growth factor receptor function
shp-2 phosphatase regulates dna damage-induced apoptosis and g2/m arrest in catalytically dependent and independent manners, respectively
interferon--induced expression of phospholipid scramblase 1 through stat1 requires the sequential activation of protein kinase c and jnk
gsk-3 directly phosphorylates and activates mark2/par-1
targeting of unfolded phoa to the tat translocon of escherichia coli
p38 mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis
role of the transmembrane domain of fxyd7 in structural and functional interactions with na,k-atpase
starvation-induced cleavage of the trna anticodon loop in tetrahymena thermophila
high affinity binding between copper and full-length prion protein identified by two different techniques
cholesterol-mediated neurite outgrowth is differently regulated between cortical and hippocampal neurons
adenovirus-mediated gene transfer of mutated ib kinase and ib reveal nf-b-dependent as well as nf-b-independent pathways of has1 activation
decorin core protein secretion is regulated by n-linked oligosaccharide and glycosaminoglycan additions
egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop
mycobacterium tuberculosis lipoarabinomannan-mediated irak-m induction negatively regulates toll-like receptor-dependent interleukin-12 p40 production in macrophages
polyamine transport by mammalian cells and mitochondria
regulation of luteinizing hormone receptor expression
enzymatic redesigning of biologically active heparan sulfate
transgenic small interfering rna halts amyotrophic lateral sclerosis in a mouse model
phosphoinositide specificity of and mechanism of lipid domain formation by annexin a2-p11 heterotetramer
post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway
the pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers
vat, the thermoplasma homolog of mammalian p97/vcp, is an n domain-regulated protein unfoldase
the proto-oncoprotein syt interacts with syt-interacting protein/co-activator activator (sip/coaa), a human nuclear receptor co-activator with similarity to ews and..
glycogen synthase kinase 3 modulates synphilin-1 ubiquitylation and cellular inclusion formation by siah
the tissue factor requirement in blood coagulation
regulation of transforming growth factor- signaling and pdk1 kinase activity by physical interaction between pdk1 and serine-threonine kinase receptor-associated pr..
altered glycosylated prp proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties
crystallographic trapping of the glutamyl-coa thioester intermediate of family i coa transferases
the needle component of the type iii secreton of shigella regulates the activity of the secretion apparatus
cement proteins of the tube-building polychaete phragmatopoma californica
cathepsin d and h2o2 stimulate degradation of thioredoxin-
the p2x7 nucleotide receptor mediates skeletal mechanotransduction
bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia
genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule
identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter slc2a7 (glut7)
cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3
the role of polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation
proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-1-induced release of extracellular fibroblast growth factor-2 and phos..
nuclear localization of stat5a modified with o-linked n-acetylglucosamine and early involution in the mammary gland of hirosaki hairless rat
the human enhancer blocker ctc-binding factor interacts with the transcription factor kaiso
pkc mediates testosterone-induced increases in coronary smooth muscle cav1.2
the mechanism of membrane targeting of human sphingosine kinase 1
why is the arg5-glu13 salt bridge conserved in mammalian -defensins?
discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators
tak1 is recruited to the tumor necrosis factor- (tnf-) receptor 1 complex in a receptor-interacting protein (rip)-dependent manner and cooperates with mekk3 leading..
receptor activator of nf-b (rank) cytoplasmic motif, 369pfqep373, plays a predominant role in osteoclast survival in part by activating akt/pkb and its downstream e..
the crystal structure of the bacillus anthracis spore surface protein bcla shows remarkable similarity to mammalian proteins
the docosatriene protectin d1 is produced by th2 skewing and promotes human t cell apoptosis via lipid raft clustering
nuclear export determines the cytokine sensitivity of stat transcription factors
wox1 is essential for tumor necrosis factor-, uv light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes s..
perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase
poly(adp-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by nad+ depletion and reduced sir2 deacetylase activity
mammalian smaug is a translational repressor that forms cytoplasmic foci similar to stress granules
functionally important substructures of circadian clock protein kaib in a unique tetramer complex
dj-1 up-regulates glutathione synthesis during oxidative stress and inhibits a53t -synuclein toxicity
recombinant addition of n-glycosylation sites to the basolateral na,k-atpase 1 subunit results in its clustering in caveolae and apical sorting in hgt-1 cells
the murine orthologue of human antichymotrypsin
comparison of structure and dynamics of micelle-bound human -synuclein and parkinson disease variants
stimulatory cross-talk between nfat3 and estrogen receptor in breast cancer cells
subplasmalemmal mitochondria modulate the activity of plasma membrane ca2+-atpases
identification of the preprotein binding domain of seca
trp-ml1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage
lack of abca1 considerably decreases brain apoe level and increases amyloid deposition in app23 mice
deletion of abca1 increases a deposition in the pdapp transgenic mouse model of alzheimer disease
the absence of abca1 decreases soluble apoe levels but does not diminish amyloid deposition in two murine models of alzheimer disease
rhob protects human keratinocytes from uvb-induced apoptosis through epidermal growth factor receptor signaling
c-myb and members of the c-ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor..
site-specific monoubiquitination of ib kinase ikk regulates its phosphorylation and persistent activation
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