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enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin
physical and kinetic interactions between glutamyl-trna reductase and glutamate-1-semialdehyde aminotransferase of chlamydomonas reinhardtii
a novel class of dual-family immunophilins
multiple mixed lineage leukemia (mll) fusion proteins suppress p53-mediated response to dna damage
hmi1p from saccharomyces cerevisiae mitochondria is a structure-specific dna helicase
sumo modification of the ets-related transcription factor erm inhibits its transcriptional activity
regulation of the g2/m transition in xenopus oocytes by the camp-dependent protein kinase
interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon -induced rantes/ccl5 expression in macrophages
role of creb1 and nfb-p65 in the down-regulation of renin gene expression by tumor necrosis factor
rac-gap-dependent inhibition of breast cancer cell proliferation by 2-chimerin
differential roles for sox15 and sox2 in transcriptional control in mouse embryonic stem cells
asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators
thrombopoietin complements gi- but not gq-dependent pathways for integrin iib3 activation and platelet aggregation
role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury
pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein
-arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the mdm2 e3 ligase
phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellul..
yin yang 1 cooperates with activator protein 2 to stimulate erbb2 gene expression in mammary cancer cells
the yeast f1f0-atp synthase
bone morphogenetic protein (bmp) type ii receptor deletion reveals bmp ligand-specific gain of signaling in pulmonary artery smooth muscle cells
thioesterase activity and acyl-coa/fatty acid cross-talk of hepatocyte nuclear factor-4
a role for mixed lineage kinases in regulating transcription factor ccaat/enhancer-binding protein--dependent gene expression in response to interferon-
mitochondrial deoxynucleotide pools in quiescent fibroblasts
alkali cation binding and permeation in the rat organic cation transporter roct2
sterically locked synthetic bilin derivatives and phytochrome agp1 from agrobacterium tumefaciens form photoinsensitive pr- and pfr-like adducts
brca1/bard1 ubiquitinate phosphorylated rna polymerase ii
parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants
glycosphingolipid accumulation inhibits cholesterol efflux via the abca1/apolipoprotein a-i pathway
cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis
yeast mrna poly(a) tail length control can be reconstituted in vitro in the absence of pab1p-dependent poly(a) nuclease activity
identification and active expression of the mycobacterium tuberculosis gene encoding 5-phospho--d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransfe..
a novel monothiol glutaredoxin (grx4) from escherichia coli can serve as a substrate for thioredoxin reductase
molecular mapping of functionalities in the solution structure of reduced grx4, a monothiol glutaredoxin from escherichia coli
atp binding to nucleotide binding domain (nbd)1 of the clpb chaperone induces motion of the long coiled-coil, stabilizes the hexamer, and activates nbd2
identification and structural determination of the m3 muscarinic acetylcholine receptor basolateral sorting signal
identification of novel cytosolic phospholipase a2s, murine cpla2,, and, which form a gene cluster with cpla2
g protein activation without subunit dissociation depends on a gi-specific region
a peptide triggers allostery in tet repressor by binding to a unique site
nuclear matrix binding regulates satb1-mediated transcriptional repression
solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains
expression profile of osteoblast lineage at defined stages of differentiation
an essential tryptophan of escherichia coli dnaa protein functions in oligomerization at the e. coli replication origin
interaction of the salmonella-containing vacuole with the endocytic recycling system
identification and characterization of novel isoforms of human dp-
caenorhabditus elegans arrestin regulates neural g protein signaling and olfactory adaptation and recovery
identification of an essential cleavage site in cole7 required for import and killing of cells
hyperphosphorylation of the bard1 tumor suppressor in mitotic cells
platelet endothelial aggregation receptor 1 (pear1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-indu..
cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activation
p21-activated kinase 1 (pak1)-dependent phosphorylation of raf-1 regulates its mitochondrial localization, phosphorylation of bad, and bcl-2 association
transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells
intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins
combined proteome and metabolite-profiling analyses reveal surprising insights into yeast sulfur metabolism
transcriptional regulation of nanog by oct4 and sox2
a multifunctional domain of the calcium-responsive transactivator (crest) that inhibits dendritic growth in cultured neurons
a novel 43-kda protein as a negative regulatory component of phenoloxidase-induced melanin synthesis
cellular quality control screening to identify amino acid pairs for substituting the disulfide bonds in immunoglobulin fold domains
a three-component dicamba o-demethylase from pseudomonas maltophilia, strain di-
an early event in adipogenesis, the nuclear selection of the ccaat enhancer-binding protein (c/ebp) mrna by hur and its translocation to the cytosol
membrane-proximal / stalk interactions differentially regulate integrin activation
def1p is involved in telomere maintenance in budding yeast
domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity
the foot structure from the type 1 ryanodine receptor is required for functional coupling to store-operated channels
characterization of a mouse second leukotriene b4 receptor, mblt
the expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code
the atpase activity of bfpd is greatly enhanced by zinc and allosteric interactions with other bfp proteins
immediate early gene x1 (iex-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in hela cells
the role of protein-tyrosine phosphatase 1b in integrin signaling
two residues of rubisco activase involved in recognition of the rubisco substrate
pronounced conformational changes following agonist activation of the m3 muscarinic acetylcholine receptor
fine tuning of the specificity of an anti-progesterone antibody by first and second sphere residue engineering
mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase
the iron-sulfur cluster of the rieske iron-sulfur protein functions as a proton-exiting gate in the cytochrome bc1 complex
activation of nur77 by selected 1,1-bis(3‘-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways
characterization of the interaction between interleukin-13 and interleukin-13 receptors
subunit assembly of n-methyl-d-aspartate receptors analyzed by fluorescence resonance energy transfer
raf kinase inhibitory protein regulates raf-1 but not b-raf kinase activation
akt-dependent expression of naip-1 protects neurons against amyloid- toxicity
identification of fez1 as a protein that interacts with jc virus agnoprotein and microtubules
inhibiting map kinase activity prevents calcium transients and mitosis entry in early sea urchin embryos
identification of a cyclin t-binding domain in hexim1 and biochemical analysis of its binding competition with hiv-1 tat
sites of tau important for aggregation populate -structure and bind to microtubules and polyanions
cellular distribution, post-translational modification, and tumorigenic potential of human group iii secreted phospholipase a2
molecular basis of intramolecular electron transfer in sulfite-oxidizing enzymes is revealed by high resolution structure of a heterodimeric complex of the catalyti..
direct interaction of the n-terminal domain of focal adhesion kinase with the n-terminal transactivation domain of p53
structural determinants of factor ix(a) binding in nitrophorin 2, a lipocalin inhibitor of the intrinsic coagulation pathway
sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases
functional selectivity of g protein signaling by agonist peptides and thrombin for the protease-activated receptor-1
activated mitofusin 2 signals mitochondrial fusion, interferes with bax activation, and reduces susceptibility to radical induced depolarization
crystallin b-i4f mutant protein binds to -crystallin and affects lens transparency
membrane type-1 matrix metalloproteinase (mt1-mmp) exhibits an important intracellular cleavage function and causes chromosome instability
mechanisms of cytoplasmic -catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from..
analysis of binding sites in human c-reactive protein for fcri, fcriia, and c1q by site-directed mutagenesis
cleavage site selection within a folded substrate by the atp-dependent lon protease
crystal structure of bmp-9 and functional interactions with pro-region and receptors
conformational dependence of intracellular nadh on metabolic state revealed by associated fluorescence anisotropy
plc1p, arg82p, and kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in saccharomyc..
caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer
functional characterization of the iron-regulatory transcription factor fep1 from schizosaccharomyces pombe
eukaryotic translation initiation factor 4e is a cellular target for toxicity and death due to exposure to cadmium chloride
cyclic amp and akap-mediated targeting of protein kinase a regulates lactate dehydrogenase subunit a mrna stability
identification of the major urinary metabolite of the highly reactive cyclopentenone isoprostane 15-a2t-isoprostane in vivo
cadmium down-regulates human ogg1 through suppression of sp1 activity
cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via amp-activated protein kinase
ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the erk1/2 signaling pathway
accumulation of diacylglycerol in the chlamydia inclusion vacuole
proteolytic cleavage of extracellular secreted -synuclein via matrix metalloproteinases
cross-talk between fmlp and vitronectin receptors triggered by urokinase receptor-derived srsry peptide
sigirr inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms
isolation of sterol-resistant chinese hamster ovary cells with genetic deficiencies in both insig-1 and insig-2
anti-lipolytic action of amp-activated protein kinase in rodent adipocytes
pituitary adenylyl cyclase-activating polypeptide 38 reduces astroglial proliferation by inhibiting the gtpase rhoa
selective induction of the tumor marker glutathione s-transferase p1 by proteasome inhibitors
comprehensive analysis of cytosolic nudix hydrolases in arabidopsis thaliana
thioredoxin reductase is irreversibly modified by curcumin
calcium-dependent activation of interleukin-21 gene expression in t cells
transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone h2a.z
glutathione redox state regulates mitochondrial reactive oxygen production
o-glcnacase uses substrate-assisted catalysis
carbon source-dependent assembly of the snf1p kinase complex in candida albicans
sp3/sp1 transcription activity regulates specific expression of collagen type x in hypertrophic chondrocytes
stearoyl-coa desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells
mitochondrial respiratory chain and nad(p)h oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle
the rna-binding protein hur binds to acetylcholinesterase transcripts and regulates their expression in differentiating skeletal muscle cells
-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop
chemical and biological evidence for base propenals as the major source of the endogenous m1dg adduct in cellular dna
apolipoprotein a-v-heparin interactions
regulation of apoptosis signal-regulating kinase 1 (ask1) by polyamine levels via protein phosphatase 5
physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis
a novel anti-platelet monoclonal antibody (3c7) specific for the complex of integrin iib3 inhibits platelet aggregation and adhesion
protein kinase c phosphorylation of the metabotropic glutamate receptor mglur5 on serine 839 regulates ca2+ oscillations
the oligomeric t4 primase is the functional form during replication
retrieval and reuse of pituitary secretory granule proteins
the broadly selective human na+/nucleoside cotransporter (hcnt3) exhibits novel cation-coupled nucleoside transport characteristics
analysis of the dna substrate specificity of the human bach1 helicase associated with breast cancer
cross-talk between signaling pathways regulates alternative splicing
pdgf-bb regulates p27 expression through erk-dependent rna turn-over in vascular smooth muscle cells
substrate-dependent differences in u2af requirement for splicing in adenovirus-infected cell extracts
phosphorylation of mammalian target of rapamycin (mtor) at ser-2448 is mediated by p70s6 kinase
role for protein phosphatase 2a in the regulation of calu-3 epithelial na+-k+-2cl-, type 1 co-transport function
the human mitochondrial transcription termination factor (mterf) is fully active in vitro in the non-phosphorylated form
tissue-specific changes in h19 methylation and expression in mice with hyperhomocysteinemia
proximity of transmembrane domains 1 and 3 of the -aminobutyric acid transporter gat-1 inferred from paired cysteine mutagenesis
integrase mutants defective for interaction with ledgf/p75 are impaired in chromosome tethering and hiv-1 replication
shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface
structure of escherichia coli ump kinase differs from that of other nucleoside monophosphate kinases and sheds new light on enzyme regulation
keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican
src regulates distinct pathways for cell volume control through vav and phospholipase c
reduction of irreversible protein adsorption on solid surfaces by protein engineering for increased stability
mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis
fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (nrf2) in spinal cord astrocytes
glycodelin-s in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa
elucidation of gene-to-gene and metabolite-to-gene networks in arabidopsis by integration of metabolomics and transcriptomics
dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, plasmodium falciparum transporter pf..
exogenously added fibroblast growth factor 2 (fgf-2) to nih3t3 cells interacts with nuclear ribosomal s6 kinase 2 (rsk2) in a cell cycle-dependent manner
nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein cad
membrane cholesterol content accounts for developmental differences in surface b cell receptor compartmentalization and signaling
mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-coas
-kinase 1, a new component in apical protein transport
energetic and structural consequences of perturbing gly-193 in the oxyanion hole of serine proteases
dynamic interaction between the dual specificity phosphatase mkp7 and the jnk3 scaffold protein -arrestin 2
interactions of motx with moty and with the poma/pomb sodium ion channel complex of the vibrio alginolyticus polar flagellum
rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5‘,5-triiodo-l-thyronine and inhibit homodimer formation
characterization of complexes formed between tsg-6 and inter--inhibitor that act as intermediates in the covalent transfer of heavy chains onto hyaluronan
analysis of double-stranded rna-induced apoptosis pathways using interferon-response noninducible small interfering rna expression vector library
structure of the g60a mutant of ras
remote site control of an active site fidelity checkpoint in a viral rna-dependent rna polymerase
an alliance between ras gtpase-activating protein, filamin c, and ras gtpase-activating protein sh3 domain-binding protein regulates myocyte growth
an obligatory intermediate in the folding pathway of cytochrome c552 from hydrogenobacter thermophilus
structure and mechanism of the alkyl hydroperoxidase ahpc, a key element of the mycobacterium tuberculosis defense system against oxidative stress
novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa
the low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein e but does not modify amyloid plaque pathology in..
the jak1 sh2 domain does not fulfill a classical sh2 function in jak/stat signaling but plays a structural role for receptor interaction and up-regulation of recept..
snap-29-mediated modulation of synaptic transmission in cultured hippocampal neurons
functional diversity of csk, chk, and src sh2 domains due to a single residue variation
mirk/dyrk1b mediates survival during the differentiation of c2c12 myoblasts
regulation of the proapoptotic arts protein by ubiquitin-mediated degradation
rapid transbilayer movement of ceramides in phospholipid vesicles and in human erythrocytes
an exo--1,3-galactanase having a novel -1,3-galactan-binding module from phanerochaete chrysosporium
search of factors that intermediate cytokine-induced group iia phospholipase a2 expression through the cytosolic phospholipase a2- and 12/15-lipoxygenase-dependent ..
a cryptic rab1-binding site in the p115 tethering protein
interferon activates nf-b in jak1-deficient cells through a tyk2-dependent pathway
regulation of smooth muscle-specific gene expression by homeodomain proteins, hoxa10 and hoxb8
ketone bodies stimulate chaperone-mediated autophagy
functional characterization of novel alternatively spliced clc-2 chloride channel variants in the heart
lman1 and mcfd2 form a cargo receptor complex and interact with coagulation factor viii in the early secretory pathway
the bacterial ybak protein is a cys-trnapro and cys-trnacys deacylase
spatial segregation of -secretase and substrates in distinct membrane domains
glutathionylation of two cysteine residues in paired domain regulates dna binding activity of pax-8
double-spanning plant viral movement protein integration into the endoplasmic reticulum membrane is signal recognition particle-dependent, translocon-mediated, and ..
surfactant protein a is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid
disabled-2 (dab2) mediates transforming growth factor (tgf)-stimulated fibronectin synthesis through tgf-activated kinase 1 and activation of the jnk pathway
nicotinic acetylcholine receptor subunits and associated proteins in human sperm
molecular and functional characterization of o antigen transfer in vibrio cholerae
characterization of lysine 56 of histone h3 as an acetylation site in saccharomyces cerevisiae
phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified
ferredoxin-nadp+ reductase
novel 3‘-ribonuclease and 3‘-phosphatase activities of the bacterial non-homologous end-joining protein, dna ligase d
an intersubunit zinc binding site in rat p2x2 receptors
targeting the nad7 subunit to mitochondria restores a functional complex i and a wild type phenotype in the nicotiana sylvestris cms ii mutant lacking nad7
differential involvement of erk2 and p38 in platelet adhesion to collagen
sphingosine activates protein kinase a type ii by a novel camp-independent mechanism
inhibition of cellular hiv-1 protease activity by lysyl-trna synthetase
the pro335 leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change
phospholipids as determinants of membrane protein topology
activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
viscosity effects on eukaryotic nitrate reductase activity
differential regulation of amino acid transporter snat3 by insulin in hepatocytes
n-glycans of caenorhabditis elegans are specific to developmental stages
y25s variant of paracoccus pantotrophus cytochrome cd1 provides insight into anion binding by d1 heme and a rare example of a critical difference between solution a..
characterization of chpbk, an mrna interferase from escherichia coli
identification of s6 kinase 1 as a novel mammalian target of rapamycin (mtor)-phosphorylating kinase
protein l-isoaspartyl methyltransferase catalyzes in vivo racemization of aspartate-25 in mammalian histone h2b
association between archaeal prolyl- and leucyl-trna synthetases enhances trnapro aminoacylation
phosphorylation of the yeast choline kinase by protein kinase c
nuclear factor of activated t cells and serum response factor cooperatively regulate the activity of an -actin intronic enhancer
cooperativity and pseudo-cooperativity in the glutathione s-transferase from plasmodium falciparum
thiocyanate modulates the catalytic activity of mammalian peroxidases
5-formyltetrahydrofolate is an inhibitory but well tolerated metabolite in arabidopsis leaves
recognition of phospholipids in streptomyces phospholipase d
interactive sites in the myd88 toll/interleukin (il) 1 receptor domain responsible for coupling to the il1 signaling pathway
mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing
the formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring l4..
a superhelical spiral in the escherichia coli dna gyrase a c-terminal domain imparts unidirectional supercoiling bias
disruption of fusion results in mitochondrial heterogeneity and dysfunction
chloramphenicol-induced mitochondrial stress increases p21 expression and prevents cell apoptosis through a p21-dependent pathway
residue leu-641 of acetyl-coa synthetase is critical for the acetylation of residue lys-609 by the protein acetyltransferase enzyme of salmonella enterica
on the interaction between amiloride and its putative -subunit epithelial na+ channel binding site
kaposi‘s sarcoma-associated herpesvirus activation of vascular endothelial growth factor receptor 3 alters endothelial function and enhances infection
bad detects coincidence of g2/m phase and growth factor deprivation to regulate apoptosis
phosphorylation of claudin-3 at threonine 192 by camp-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells
the endophytic fungus piriformospora indica stimulates the expression of nitrate reductase and the starch-degrading enzyme glucan-water dikinase in tobacco and arab..
base catalysis of chromophore formation in arg96 and glu222 variants of green fluorescent protein
rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms
the pro-atherogenic cytokine interleukin-18 induces cxcl16 expression in rat aortic smooth muscle cells via myd88, interleukin-1 receptor-associated kinase, tumor n..
binding of activated 2-macroglobulin to its cell surface receptor grp78 in 1-ln prostate cancer cells regulates pak-2-dependent activation of limk
ryanodine receptors in muscarinic receptor-mediated bronchoconstriction
macrophages survive hyperoxia via prolonged erk activation due to phosphatase down-regulation
gly-103 in the n-terminal domain of saccharomyces cerevisiae rad51 protein is critical for dna binding
point mutational analysis of the liganding site in human glycolipid transfer protein
headgroup-specific exposure of phospholipids in abca1-expressing cells
lipid droplets gain pat family proteins by interaction with specialized plasma membrane domains
estrogen inhibits cardiomyocyte hypertrophy in vitro
identification of the virb4-virb8-virb5-virb2 pilus assembly sequence of type iv secretion systems
translocation of dynorphin neuropeptides across the plasma membrane
structural and mutational analysis of trypanosoma brucei prostaglandin h2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases
mitochondrial dok-4 recruits src kinase and regulates nf-b activation in endothelial cells
7-nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione s-transferases
cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase cd39
direct binding to ceramide activates protein kinase c before the formation of a pro-apoptotic complex with par-4 in differentiating stem cells
caspase-dependent and -independent activation of acid sphingomyelinase signaling
a two-component hydroxylase involved in the assimilation of 3-hydroxyphenyl acetate in pseudomonas putida
ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of myod and id1 during muscle differentiation
crystal structure of acetylcholine-binding protein from bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholin..
characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells
engineering conformational destabilization into mouse apolipoprotein e
insig required for sterol-mediated inhibition of scap/srebp binding to copii proteins in vitro
mammalian selenoprotein thioredoxin-glutathione reductase
magi1 recruits dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface
critical hydrophobic interactions between phosphorylation and actuator domains of ca2+-atpase for hydrolysis of phosphorylated intermediate
a novel peroxisome proliferator-activated receptor isoform with dominant negative activity generated by alternative splicing
three distinct molecular surfaces in ephrin-a5 are essential for a functional interaction with epha3
lim kinase 1 coordinates microtubule stability and actin polymerization in human endothelial cells
structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators
identification of a myosin vii-talin complex
prostaglandin e2 stimulates the -catenin/t cell factor-dependent transcription in colon cancer
the crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in corynebacterineae
a physical and functional constituent of telomerase anchor site
g protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiote..
regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo
ceramide 1-phosphate, a mediator of phagocytosis
inefficient maturation of the rat luteinizing hormone receptor
role of integrin-linked kinase in regulating phosphorylation of akt and fibroblast survival in type i collagen matrices through a 1 integrin viability signaling pat..
crystal structure of the nad biosynthetic enzyme quinolinate synthase
(d)--hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor puma-g
properties of wnk1 and implications for other family members
evolution of matrix and bone -carboxyglutamic acid proteins in vertebrates
the highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase a
a cellular deficiency of gangliosides causes hypersensitivity to clostridium perfringens phospholipase c
glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus
induction of ogg1 gene expression by hiv-1 tat
statins exert endothelial atheroprotective effects via the klf2 transcription factor
detection of human red blood cell-bound nitric oxide
inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 9
2-arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in jb6 p+ ..
mutations in tfiiia that increase stability of the tfiiia-5 s rrna gene complex
erk1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter
analysis of the heteromeric csda-csde cysteine desulfurase, assisting fe-s cluster biogenesis in escherichia coli
sost is a ligand for lrp5/lrp6 and a wnt signaling inhibitor
a chromatin-associated and transcriptionally inactive p53-mdm2 complex occurs in mdm2 snp309 homozygous cells
uncoupling the chemical steps of telomere resolution by rest
epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids
homodimeric myod preferentially binds tetraplex structures of regulatory sequences of muscle-specific genes
cap-independent translation of tobacco etch virus is conferred by an rna pseudoknot in the 5‘-leader
differential involvement of calmodulin-dependent protein kinase ii-activated ap-1 and c-jun n-terminal kinase-activated egr-1 signaling pathways in tumor necrosis f..
characterization of the final step in the conversion of phytol into phytanic acid
cross-talk between jip3 and jip1 during glucose deprivation
structural requirements for activation of latent platelet-derived growth factor cc by tissue plasminogen activator
scf-trcp controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (per1) proteinm
protease-resistant prion protein amplification reconstituted with partially purified substrates and synthetic polyanions
amyloid formation modulates the biological activity of a bacterial protein
activation of human meiosis-specific recombinase dmc1 by ca2+
endothelin-induced, long lasting, and ca2+ influx-independent blockade of intrinsic secretion in pituitary cells by gz subunits
characterization of promoter elements of the human hyal-2 gene
1-oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the n-terminal c2-like domain
regulation of the p2x7 receptor permeability to large molecules by extracellular cl- and na+
atp-independent activation of natriuretic peptide receptors
the contribution of ring and b-box 2 domains to retroviral restriction mediated by monkey trim5
krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of dlk1
differential induction of glioblastoma migration and growth by two forms of pleiotrophin
identification of l-selectin binding heparan sulfates attached to collagen type xviii
biological, biochemical, and kinetic effects of mutations of the cardiomyopathy loop of dictyostelium myosin ii
acidic residues in the nucleotide-binding site of the bacteriophage t7 dna primase
structural characterization of the intermolecular interactions of synapse-associated protein-97 with the nr2b subunit of n-methyl-d-aspartate receptors
hirudin binding reveals key determinants of thrombin allostery
tsg101 and alix interact with murine leukemia virus gag and cooperate with nedd4 ubiquitin ligases during budding
acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the caenorhabditis elegans neuromuscular junction
smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor--positive breast cancer cells
periplasmic protein hdea exhibits chaperone-like activity exclusively within stomach ph range by transforming into disordered conformation
camp-response elements in aplysia creb1, creb2, and ap-uch promoters
characterization of the interaction between tumor necrosis factor-stimulated gene-6 and heparin
the murine hcn3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides
dual role of the ric-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors
a structural basis for cd8+ t cell-dependent recognition of non-homologous peptide ligands
antisense-mediated inhibition of the plasma membrane calcium-atpase suppresses proliferation of mcf-7 cells
keratocan expression of murine keratocytes is maintained on amniotic membrane by down-regulating transforming growth factor- signaling
a variable residue in the pore of kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions
role of active site residues and solvent in proton transfer and the modulation of flavin reduction potential in bacterial morphinone reductase
peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its c terminus
determining the environment of the ligand binding pocket of the human angiotensin ii type i (hat1) receptor using the methionine proximity assay
ca2+ influx through l-type ca2+ channels controls the trailing tail contraction in growth factor-induced fibroblast cell migration
characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-eet) as potent in vivo angiogenic lipids
goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement
strong effects of an individual water molecule on the rate of light-driven charge separation in the rhodobacter sphaeroides reaction center
tissue- and gene-specific recruitment of steroid receptor coactivator-3 by thyroid hormone receptor during development
association of plasminogen with dipeptidyl peptidase iv and na+/h+ exchanger isoform nhe3 regulates invasion of human 1-ln prostate tumor cells
involvement of nadph oxidase isoforms and src family kinases in cd95-dependent hepatocyte apoptosis
methionine sulfoximine treatment and carbon starvation elicit snf1-independent phosphorylation of the transcription activator gln3 in saccharomyces cerevisiae
hclca1 and mclca3 are secreted non-integral membrane proteins and therefore are not ion channels
basigin (cd147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and
bishistidyl heme hexacoordination, a key structural property in drosophila melanogaster hemoglobin
the human solute carrier gene slc35b4 encodes a bifunctional nucleotide sugar transporter with specificity for udp-xylose and udp-n-acetylglucosamine
the agaaaaga palindrome in prp is required to generate a productive prpsc-prpc complex that leads to prion propagation
differential responses of the nrf2-keap1 system to laminar and oscillatory shear stresses in endothelial cells
janus kinases affect thrombopoietin receptor cell surface localization and stability
high resolution reaction intermediates of rabbit muscle fructose-1,6-bisphosphate aldolase
transforming growth factor--activated kinase-1 (tak1), a map3k, interacts with smad proteins and interferes with osteogenesis in murine mesenchymal progenitors
alanine scanning mutants of the hiv gp41 loop
selective inhibition of 1a-adrenergic receptor signaling by rgs2 association with the receptor third intracellular loop
neurodegeneration in heterozygous niemann-pick type c1 (npc1) mouse
low density lipoprotein receptor-related protein (lrp) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (app) for -secret..
novel class of glycosphingolipids involved in male fertility
siroheme- and [fe4-s4]-dependent nira from mycobacterium tuberculosis is a sulfite reductase with a covalent cys-tyr bond in the active site
a novel diacylglycerol-lactone shows marked selectivity in vitro among c1 domains of protein kinase c (pkc) isoforms and as well as selectivity for rasgrp compared ..
localization-independent regulation of homocysteine secretion by phosphatidylethanolamine n-methyltransferase
rapid turnover of c-flipshort is determined by its unique c-terminal tail
crystal structure of the interferon-induced ubiquitin-like protein isg15
structural and functional analyses of a novel ig-like cell adhesion molecule, hepacam, in the human breast carcinoma mcf7 cells
unfolding-resistant translocase targeting
reorganization of erbb family and cell survival signaling after knock-down of erbb2 in colon cancer cells
incorporation of factor va into prothrombinase is required for coordinated cleavage of prothrombin by factor xa
copper-catalyzed protein oxidation and its modulation by carbon dioxide
modulation of the nucleoside triphosphatase/rna helicase and 5‘-rna triphosphatase activities of dengue virus type 2 nonstructural protein 3 (ns3) by interaction w..
formation of an atp-dnaa-specific initiation complex requires dnaa arginine 285, a conserved motif in the aaa+ protein family
a novel peptide screened by phage display can mimic trap antigen epitope against staphylococcus aureus infections
stard10, a start domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein
the chaperone-associated ubiquitin ligase chip is able to target p53 for proteasomal degradation
the identification of a minimal dimerization motif qxxs that enables homo- and hetero-association of transmembrane helices in vivo
uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system
the peroxisome proliferator-activated receptor- regulates murine pyruvate carboxylase gene expression in vivo and in vitro
yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme
interaction between the cd8 coreceptor and major histocompatibility complex class i stabilizes t cell receptor-antigen complexes at the cell surface
chimeric mutations in the m2 segment of the 5-hydroxytryptamine-gated chloride channel mod-1 define a minimal determinant of anion/cation permeability
substrate specificity and recognition is conferred by the pleckstrin homology domain of the dbl family guanine nucleotide exchange factor p-rex2
natural antisense mrnas to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation
high mobility group protein-b1 interacts with sterol regulatory element-binding proteins to enhance their dna binding
thyroid hormone regulates the hypotriglyceridemic gene apoa5
inhibition of platelet-derived growth factor-induced cell growth signaling by a short interfering rna for ews-fli1 via down-regulation of phospholipase d2 in ewing ..
differentiation-dependent alterations in histone methylation and chromatin architecture at the inducible chicken lysozyme gene
phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase c-mediated protein kinase c-independent pathway
inhibition of nuclear import of limk2 in endothelial cells by protein kinase c-dependent phosphorylation at ser-283
phosphate-limited oat
identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association
efficient processing of primary microrna hairpins by drosha requires flanking nonstructured rna sequences
the role of galacturonic acid in outer membrane stability in klebsiella pneumoniae
cog1p plays a central role in the organization of the yeast conserved oligomeric golgi complex
acute reduction of an origin recognition complex (orc) subunit in human cells reveals a requirement of orc for cdk2 activation
molecular dissection of pinch-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival
regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis
aip4 restricts transforming growth factor- signaling through a ubiquitination-independent mechanism
molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in saccharomyces cerevisiae
µ and opioid receptors activate erk/mapk via different protein kinase c isoforms and secondary messengers in astrocytes
effective translation of the second cistron in two drosophila dicistronic transcripts is determined by the absence of in-frame aug codons in the first cistron
loss of outer membrane proteins without inhibition of lipid export in an escherichia coli yaet mutant
characterization of the intraflagellar transport complex b core
cooperation between small nuclear rna-activating protein complex (snapc) and tata-box-binding protein antagonizes protein kinase ck2 inhibition of dna binding by sn..
git1 is a scaffold for erk1/2 activation in focal adhesions
intracellular trafficking of thyroid peroxidase to the cell surface
characterization of four variant forms of human propionyl-coa carboxylase expressed in escherichia coli
simultaneous blockade of nfb, jnk, and p38 mapk by a kinase-inactive mutant of the protein kinase tak1 sensitizes cells to apoptosis and affects a distinct spectrum..
novel autoregulatory function of hepatitis b virus m protein on surface gene expression
inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic t cells into the pancreas
pellino3 is a novel upstream regulator of p38 mapk and activates creb in a p38-dependent manner
structural organization of a sex-comb-on-midleg/polyhomeotic copolymer
interaction of fxyd10 (plms) with na,k-atpase from shark rectal glands
fbi-1 enhances transcription of the nuclear factor-b (nf-b)-responsive e-selectin gene by nuclear localization of the p65 subunit of nf-b
staphylococcus aureus aminopeptidase s is a founding member of a new peptidase clan
endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor 1 with higher affinity receptors and an activated alk1 path..
h1 family histones in the nucleus
metabolism and transactivation activity of 13,14-dihydroretinoic acid
imaging epidermal growth factor receptor phosphorylation in human colorectal cancer cells and human tissues
crystal structure of kunitz domain 1 (kd1) of tissue factor pathway inhibitor-2 in complex with trypsin
the fucose-binding lectin from ralstonia solanacearum
mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit
a causative role of stromelysin-3 in extracellular matrix remodeling and epithelial apoptosis during intestinal metamorphosis in xenopus laevis
cell surface expression of cd147/emmprin is regulated by cyclophilin 60
platelet-derived growth factor receptor- (pdgfr-) activation promotes its association with the low density lipoprotein receptor-related protein (lrp)
roles for c16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-
inhibition of activator protein-1, nf-b, and mapks and induction of phase 2 detoxifying enzyme activity by chlorogenic acid
cysteine-mediated cross-linking indicates that subunit c of the v-atpase is in close proximity to subunits e and g of the v1 domain and subunit a of the v0 domain
the 1.3 å crystal structure of the flavoprotein yqjm reveals a novel class of old yellow enzymes
a new arrangement of (/)8 barrels in the synthase subunit of plp synthase
uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors
peptides derived from human decorin leucine-rich repeat 5 inhibit angiogenesis
innate immune defense of the sponge suberites domuncula against bacteria involves a myd88-dependent signaling pathway
quantitative calcium measurements in subcellular compartments of plasmodium falciparum-infected erythrocytes
the prodomain of bmp-7 targets the bmp-7 complex to the extracellular matrix
modulation of charge in the phosphate binding site of escherichia coli atp synthase
structural insights into the mechanism of nuclease a, a metal nuclease from anabaena
human aldehyde dehydrogenase 3a1 inhibits proliferation and promotes survival of human corneal epithelial cells
cross-species sequence analysis reveals multiple charged residue-rich domains that regulate nuclear/cytoplasmic partitioning and membrane localization of a kinase a..
functional analysis of slac2-c/myrip as a linker protein between melanosomes and myosin viia
differential activities and regulation of saccharomyces cerevisiae formin proteins bni1 and bnr1 by bud6
contribution of the carboxyl terminus of the vpac1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling
secretory phospholipases a2 induce neurite outgrowth in pc12 cells through lysophosphatidylcholine generation and activation of g2a receptor
ric-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains
transcriptional activity of sp1 is regulated by molecular interactions between the zinc finger dna binding domain and the inhibitory domain with corepressors, and t..
biochemical analysis of the dna unwinding and strand annealing activities catalyzed by human recq1
recq1 helicase interacts with human mismatch repair factors that regulate genetic recombination
a novel porphyromonas gingivalis feob plays a role in manganese accumulation
caveolin-1 is not required for murine intestinal cholesterol transport
inhibition of glycosphingolipid biosynthesis reduces secretion of the -amyloid precursor protein and amyloid -peptide
the cotranslational contacts between ribosome-bound nascent polypeptides and the subunits of the hetero-oligomeric chaperonin tric probed by photocross-linking
role of p97 aaa-atpase in the retrotranslocation of the cholera toxin a1 chain, a non-ubiquitinated substrate
induction of p53 by urokinase in lung epithelial cells
a role for mitogen-activated protein kinaseerk1/2 activation and non-selective pore formation in p2x7 receptor-mediated thymocyte death
ctcf regulates growth and erythroid differentiation of human myeloid leukemia cells
genetic and pharmacologic evidence that calcium-independent phospholipase a2 regulates virus-induced inducible nitric-oxide synthase expression by macrophages
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