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免疫学杂志2004年第05期封面 购买


accommodation: preventing injury in transplantation and disease
cutting edge: tgf- induces a regulatory phenotype in cd4 + cd25 - t cells through foxp3 induction and down-regulation of smad
cutting edge: il-21 is a switch factor for the production of igg 1 and igg 3 by human b cells
paracrine release of il-12 stimulates ifn- production and dramatically enhances the antigen-specific t cell response after vaccination with a novel peptide-based ca..
breaking immune tolerance to the prion protein using prion protein peptides plus oligodeoxynucleotide-cpg in mice
toll-like receptor signaling alters the expression of regulator of g protein signaling proteins in dendritic cells: implications for g protein-coupled receptor sign..
enzymatically quiescent heparanase augments t cell interactions with vcam-1 and extracellular matrix components under versatile dynamic contexts
inflammatory cytokines overcome age-related defects in cd4 t cell responses in vivo
ctl-dependent and -independent antitumor immunity is determined by the tumor not the vaccine
dihydropyridine receptors are selective markers of th2 cells and can be targeted to prevent th2-dependent immunopathological disorders
natural and induced cd4 + cd25 + cells educate cd4 + cd25 - cells to develop suppressive activity: the role of il-2, tgf-, and il-10
passive and active mechanisms trap activated cd8 + t cells in the liver
obligatory role for cooperative signaling by pre-tcr and notch during thymocyte differentiation
antigen-specific t cell repertoire modification of cd4 + cd25 + regulatory t cells
the hiv-1 hla-a2-slyntvatl is a help-independent ctl epitope
pro-th1 cytokines promote fas-dependent apoptosis of immature peripheral basophils
igg2a-mediated enhancement of antibody and t cell responses and its relation to inhibitory and activating fc receptors
bacterial heat shock proteins promote cd91-dependent class i mhc cross-presentation of chaperoned peptide to cd8 + t cells by cytosolic mechanisms in dendritic cell..
distinct il-2 receptor signaling pattern in cd4 + cd25 + regulatory t cells
platelets, after exposure to a high shear stress, induce il-10-producing, mature dendritic cells in vitro
cd1d1 displayed on cell size beads identifies and enriches an nk cell population negatively regulated by cd1d1
editing rescues autoreactive b cells destined for deletion in mice transgenic for a dual specific anti-laminin ig
autoreactive t cells persist in rats protected against experimental autoimmune encephalomyelitis and can be activated through stimulation of innate immunity
latent membrane protein 2a, a viral b cell receptor homologue, induces cd5 + b-1 cell development
in vivo cyclophosphamide and il-2 treatment impedes self-antigen-induced effector cd4 cell tolerization: implications for adoptive immunotherapy
the magnitude of tcr engagement is a critical predictor of t cell anergy or activation
deficiencies in gut nk cell number and function precede diabetes onset in bb rats
role of cross-talk between ifn- -induced monocyte-derived dendritic cells and nk cells in priming cd8 + t cell responses against human tumor antigens
human t cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic t cells with regulatory cell activity
control of tcr-mediated activation of 1 integrins by the zap-70 tyrosine kinase interdomain b region and the linker for activation of t cells adapter protein
the distribution of antigen in lymphoid tissues following its injection into the anterior chamber of the rat eye
dendritic cells exposed to herpes simplex virus in vivo do not produce ifn- after rechallenge with virus in vitro and exhibit decreased t cell alloreactivity
cathepsin-dependent apoptosis triggered by supraoptimal activation of t lymphocytes: a possible mechanism of high dose tolerance
nonmyeloablative bone marrow transplantation of bxsb lupus mice using fully matched allogeneic donor cells from green fluorescent protein transgenic mice
helper requirements for generation of effector ctl to islet cell antigens
modular nature of blimp-1 in the regulation of gene expression during b cell maturation
a proline-rich motif in the c terminus of akt contributes to its localization in the immunological synapse
lymphocyte activation gene-3 (cd223) regulates the size of the expanding t cell population following antigen activation in vivo
in vivo helper functions of alloreactive memory cd4 + t cells remain intact despite donor-specific transfusion and anti-cd40 ligand therapy
il-4 protects tumor cells from anti-cd95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins
mutational analysis of terminal deoxynucleotidyltransferase- mediated n-nucleotide addition in v(d)j recombination
v region carbohydrate and antibody expression
cathepsin g, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human b lymphocytes
determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from ctl recognition
human cd1d gene has tata boxless dual promoters: an sp1-binding element determines the function of the proximal promoter
reciprocal control of forkhead box o 3a and c-myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27 kip1 levels
cathepsin e: a novel target for regulation by class ii transactivator
the mouse homologue of the leukocyte-associated ig-like receptor-1 is an inhibitory receptor that recruits src homology region 2-containing protein tyrosine phospha..
allelic exclusion at the tcr locus and commitment to lineage: different modalities apply to distinct human subsets
hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific cd8 + t cell responses: correlation of cytokine profile and tcr avidity
induction in humans of cd8 + and cd4 + t cell and antibody responses by sequential immunization with malaria dna and recombinant protein
inhibition of 19-kda c-terminal region of merozoite surface protein-1-specific antibody responses in neonatal pups by maternally derived 19-kda c-terminal region of..
initial stages of mammary tumor virus infection are superantigen independent
increased mitogen-activated protein kinase activity and tnf- production associated with mycobacterium smegmatis - but not mycobacterium avium -infected macrophages ..
influenza a vaccine based on the extracellular domain of m2: weak protection mediated via antibody-dependent nk cell activity
protective activity of monoclonal antibodies to genome-derived neisserial antigen 1870, a neisseria meningitidis candidate vaccine
enteric nematodes induce stereotypic stat6-dependent alterations in intestinal epithelial cell function
immune-deficient drosophila melanogaster : a model for the innate immune response to human fungal pathogens 1,
specific recognition of the viral protein ul18 by cd85j/lir-1/ilt2 on cd8 + t cells mediates the non-mhc-restricted lysis of human cytomegalovirus-infected cells
distinctive roles for 2‘,5‘-oligoadenylate synthetases and double-stranded rna-dependent protein kinase r in the in vivo antiviral effect of an adenoviral vector ..
il-6 prevents t cell-mediated hepatitis via inhibition of nkt cells in cd4 + t cell- and stat3-dependent manners
arthritogenic properties of double-stranded (viral) rna
immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase
differential regulation of neutrophil-activating chemokines by il-6 and its soluble receptor isoforms
generation of an allergy vaccine by disruption of the three-dimensional structure of the cross-reactive calcium-binding allergen, phl p 7
endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection
effects of complement c5 on apoptosis in experimental autoimmune encephalomyelitis
substance p augments borrelia burgdorferi -induced prostaglandin e 2 production by murine microglia
suppressor of cytokine signaling-1 overexpression protects pancreatic cells from cd8 + t cell-mediated autoimmune destruction
activation of endoplasmic reticulum-specific stress responses associated with the conformational disease z 1-antitrypsin deficiency
phosphoinositide 3-kinase and akt occupy central roles in inflammatory responses of toll-like receptor 2-stimulated neutrophils
monosodium urate crystals synergize with ifn- to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and nf- b
circulating immune complexes augment severity of antibody-mediated myasthenia gravis in hypogammaglobulinemic riiis/j mice
metastable tolerance to rhesus monkey renal transplants is correlated with allograft tgf- 1 + cd4 + t regulatory cell infiltrates
identification of anti-plasmin antibodies in the antiphospholipid syndrome that inhibit degradation of fibrin
regulation of postsurgical fibrosis by the programmed death-1 inhibitory pathway
treatment with -galactosylceramide attenuates the development of bleomycin-induced pulmonary fibrosis
peroxisome proliferator-activated receptor agonists as therapy for autoimmune disease
dna acrobats of the ig class switch
cutting edge: the natural ligand for glucocorticoid-induced tnf receptor-related protein abrogates regulatory t cell suppression
cutting edge: extracellular signal-regulated kinases 1/2 function as integrators of tcr signal strength
cutting edge: c3d functions as a molecular adjuvant in the absence of cd21/35 expression
cutting edge: trem-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inh..
shift from systemic to site-specific memory by tumor-targeted il-2
evolutionary origins of lymphocytes: ensembles of t cell and b cell transcriptional regulators in a cartilaginous fish
cpg motifs as proinflammatory factors render autochthonous tumors permissive for infiltration and destruction
differential gene expression patterns by oligonucleotide microarray of basal versus lipopolysaccharide-activated monocytes from cord blood versus adult peripheral b..
cd28 signals in the immature immunological synapse
cd4 raft association and signaling regulate molecular clustering at the immunological synapse site
depletion of cd8 + cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the th1/th2 cytokine profile
generation of anergic and regulatory t cells following prolonged exposure to a harmless antigen
up-regulation of cd1d expression restores the immunoregulatory function of nkt cells and prevents autoimmune diabetes in nonobese diabetic mice
the inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of cd28
heart, but not skin, allografts from donors lacking flt3 ligand exhibit markedly prolonged survival time
an inhibitory ig superfamily protein expressed by lymphocytes and apcs is also an early marker of thymocyte positive selection
curcumin (diferuloylmethane) inhibits receptor activator of nf- b ligand-induced nf- b activation in osteoclast precursors and suppresses osteoclastogenesis
conversion of ctla-4 from inhibitor to activator of t cells with a bispecific tandem single-chain fv ligand
il-4 confers nk stimulatory capacity to murine dendritic cells: a signaling pathway involving karap/dap12-triggering receptor expressed on myeloid cell 2 molecules
autoreactive t cells in healthy individuals
il-2 induces a competitive survival advantage in t lymphocytes
adult human liver contains cd8 pos t cells with naive phenotype, but is not a site for conventional t cell development
il-10-secreting regulatory t cells do not express foxp3 but have comparable regulatory function to naturally occurring cd4 + cd25 + regulatory t cells
thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic t cells
induction of foxp3 + regulatory t cells in the periphery of t cell receptor transgenic mice tolerized to transplants
the serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release
the role of il-5 for mature b-1 cells in homeostatic proliferation, cell survival, and ig production
the ability of two listeria monocytogenes vaccines targeting human papillomavirus-16 e7 to induce an antitumor response correlates with myeloid dendritic cell funct..
stimulation by soluble cd70 promotes strong primary and secondary cd8 + cytotoxic t cell responses in vivo
the role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-oh kinase signal transduction pathways in cd40 l..
t cells associated with tumor regression recognize frameshifted products of the cdkn2a tumor suppressor gene locus and a mutated hla class i gene product
toll-like receptor ligands directly promote activated cd4 + t cell survival
the tumoricidal activity of memory cd8 + t cells is hampered by persistent systemic antigen, but full functional capacity is regained in an antigen-free environment
the toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with ifn- to reverse the th2 skew in an in vitro allergy model
glycoprotein 96 can chaperone both mhc class i- and class ii-restricted epitopes for in vivo presentation, but selectively primes cd8 + t cell effector function
restoration of nk t cell development in fyn -mutant mice by a tcr reveals a requirement for fyn during early nk t cell ontogeny
il-9-induced expansion of b-1b cells restores numbers but not function of b-1 lymphocytes in xid mice
the size and phenotype of virus-specific t cell populations is determined by repetitive antigenic stimulation and environmental cytokines
cd1d-independent nkt cells in 2 -microglobulin-deficient mice have hybrid phenotype and function of nk and t cells
human cd4 + cd25 + regulatory t cells share equally complex and comparable repertoires with cd4 + cd25 - counterparts
loading of mhc class i and ii presentation pathways by exogenous antigens: a quantitative in vivo comparison
il-2 secretion by cd4 + t cells in vivo is rapid, transient, and influenced by tcr-specific competition
transcriptional activation of the sh2d2a gene is dependent on a cyclic adenosine 5‘-monophosphate-responsive element in the proximal sh2d2a promoter
genetic makeup of the dr region in rhesus macaques: gene content, transcripts, and pseudogenes
il-4-induced gata-3 expression is a time-restricted instruction switch for th2 cell differentiation
fusion of two malaria vaccine candidate antigens enhances product yield, immunogenicity, and antibody-mediated inhibition of parasite growth in vitro
structures of hla-a1101 complexed with immunodominant nonamer and decamer hiv-1 epitopes clearly reveal the presence of a middle, secondary anchor residue
lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced ifn- signaling pathway in human monocytes
lysine-dependent multipoint binding of the borrelia burgdorferi virulence factor outer surface protein e to the c terminus of factor h
toll-like receptor 4 dependence of innate and adaptive immunity to salmonella : importance of the kupffer cell network
induction of hiv immunity in the genital tract after intranasal delivery of a mva vector: enhanced immunogenicity after dna prime-modified vaccinia virus ankara boo..
immunological characteristics associated with the protective efficacy of antibodies to ricin
filaria-induced immune evasion: suppression by the infective stage of brugia malayi at the earliest host-parasite interface
visualizing the viral burden: phenotypic and functional alterations of t cells and apcs during persistent infection
mycobacterium tuberculosis -induced cxcr4 and chemokine expression leads to preferential x4 hiv-1 replication in human macrophages
iga class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut
cellular and humoral immunity against vaccinia virus infection of mice
mycobacterium tuberculosis inhibits macrophage responses to ifn- through myeloid differentiation factor 88-dependent and -independent mechanisms
dendritic cells (dc) activated by cpg dna ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of il-12 derived from the ..
immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-ad5 immunity
mouse strain susceptibility to trypanosome infection: an arginase-dependent effect
dendritic cells from mice neonatally vaccinated with modified vaccinia virus ankara transfer resistance against herpes simplex virus type i to naive one-week-old mice
viral flip impairs survival of activated t cells and generation of cd8 + t cell memory
dual role of tlr2 and myeloid differentiation factor 88 in a mouse model of invasive group b streptococcal disease
augmentation of chemotherapy-induced cytokine production by expression of the platelet-activating factor receptor in a human epithelial carcinoma cell line
transient and selective nf- b p65 serine 536 phosphorylation induced by t cell costimulation is mediated by i b kinase and controls the kinetics of p65 nuclear import
intracellular bacterial infection-induced ifn- is critically but not solely dependent on toll-like receptor 4-myeloid differentiation factor 88-ifn- -stat1 signaling
studies of congenic lines in the brown norway rat model of th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological ..
the transmembrane cxc-chemokine ligand 16 is induced by ifn- and tnf- and shed by the activity of the disintegrin-like metalloproteinase adam10
6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase form a supramolecular complex in human neutrophils that undergoes retrograde trafficking duri..
inactivation of c5a anaphylatoxin by a peptide that is complementary to a region of c5a
ectopic cd40 ligand expression on b cells triggers intestinal inflammation
mast cells, fc ri, and il-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant
the functional profile of primary human antiviral cd8 + t cell effector activity is dictated by cognate peptide concentration
attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by ifn- plus vitamin b 12 : treatment to modify notch-1/sonic hedgehog balance
generation and regulation of human th1-biased immune responses in vivo: a critical role for il-4 and il-10
cd4 + cd25 bright regulatory t cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible
antiviral cytokines induce hepatic expression of the granzyme b inhibitors, proteinase inhibitor 9 and serine proteinase inhibitor 6
lack of galactose- -1,3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic nk cytotoxicity
type i regulatory t cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris
ifn- priming results in a gain of proinflammatory function by il-10: implications for systemic lupus erythematosus pathogenesis
the novel cyclophilin-binding drug sanglifehrin a specifically affects antigen uptake receptor expression and endocytic capacity of human dendritic cells
molecular characterization of polygalacturonases as grass pollen-specific marker allergens: expulsion from pollen via submicronic respirable particles
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