il-2, regulatory t cells, and tolerance
cutting edge: innate immune system discriminates between rna containing bacterial versus eukaryotic structural features that prime for high-level il-12 secretion by..
cutting edge: cd96 (tactile) promotes nk cell-target cell adhesion by interacting with the poliovirus receptor (cd155)
ccr7 directs the migration of thymocytes into the thymic medulla
siva-1 and an alternative splice form lacking the death domain, siva-2, similarly induce apoptosis in t lymphocytes via a caspase-dependent mitochondrial pathway
antibody targeting of the cc chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a vir..
intralesional injection of adenovirus encoding cc chemokine ligand 16 inhibits mammary tumor growth and prevents metastatic-induced death after surgical removal of ..
establishment of early lymphoid organ infrastructure in transplanted tumors mediated by local production of lymphotoxin and in the combined absence of functional b ..
monomeric ige stimulates nfat translocation into the nucleus, a rise in cytosol ca 2+, degranulation, and membrane ruffling in the cultured rat basophilic leukemia-..
proinflammatory mediators and genetic background in oncogene mediated tumor progression
protection from fluorescein isothiocyanate-induced fibrosis in il-13-deficient, but not il-4-deficient, mice results from impaired collagen synthesis by fibroblasts
flt3 ligand preferentially increases the number of functionally active myeloid dendritic cells in the lungs of mice
mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen ia-2 by peptide phage display and molecular modeling: overlap of antibody and t cell deter..
src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of langerhans cells from the epidermis to draining lymph nodes
ligation of b7-1/b7-2 by human cd4 + t cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells
genome-wide analysis of molecular changes in il-12-induced control of mammary carcinoma via ifn- -independent mechanisms
cd4 + cd25 + regulatory t cells control the severity of viral immunoinflammatory lesions
microarray analysis of lyn-deficient b cells reveals germinal center-associated nuclear protein and other genes associated with the lymphoid germinal center
effect of decreasing the affinity of the class ii-associated invariant chain peptide on the mhc class ii peptide repertoire in the presence or absence of h-2m
intestinal intraepithelial lymphocyte -t cell-derived keratinocyte growth factor modulates epithelial growth in the mouse
separation of the new zealand black genetic contribution to lupus from new zealand black determined expansions of marginal zone b and b1a cells
detection of cell surface ligands for the tcr using soluble tcrs
virus-induced activation of self-specific tcr cd8 intraepithelial lymphocytes does not abolish their self-tolerance in the intestine
ctla-4 + cd8 + t cells that encounter b7-2 + iris pigment epithelial cells express their own b7-2 to achieve global suppression of t cell activation
glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of cd4 + t cell th1 cytokine production in vivo
maintenance, loss, and resurgence of t cell responses during acute, protracted, and chronic viral infections
cd4-directed peptide vaccination augments an antitumor response, but efficacy is limited by the number of cd8 + t cell precursors
monocyte surface-bound il-15 can function as an activating receptor and participate in reverse signaling
thymocytes between the -selection and positive selection checkpoints are nonresponsive to il-7 as assessed by stat-5 phosphorylation
ifn- stimulates the expression of a novel secretoglobin that regulates chemotactic cell migration and invasion
plasmacytoid dendritic cells regulate th cell responses through ox40 ligand and type i ifns
defining th1 and th2 immune responses in a reciprocal cytokine environment in vivo
enrichment of lck in lipid rafts regulates colocalized fyn activation and the initiation of proximal signals through tcr
smad3 is essential for tgf- 1 to suppress il-2 production and tcr-induced proliferation, but not il-2-induced proliferation
immune regulation by self-reactive t cells is antigen specific
tnf receptor-associated factor 5 limits the induction of th2 immune responses
lupus igg v h 4.34 antibodies bind to a 220-kda glycoform of cd45/b220 on the surface of human b lymphocytes
recombinogenic phenotype of human activation-induced cytosine deaminase
identifiying human mhc supertypes using bioinformatic methods
depletion of cellular cholesterol and lipid rafts increases shedding of cd30
tnf and phorbol esters induce lymphotoxin- expression through distinct pathways involving ets and nf- b family members
characterization of recombinant mannan-binding lectin-associated serine protease (masp)-3 suggests an activation mechanism different from that of masp-1 and masp-2 1,
mutational analyses of the recombinant globular regions of human c1q a, b, and c chains suggest an essential role for arginine and histidine residues in the c1q-igg..
localization of the domains in runx transcription factors required for the repression of cd4 in thymocytes
identification and molecular cloning of functional chicken il-12
cloning, expression, cellular distribution, and role in chemotaxis of a c5a receptor in rainbow trout: the first identification of a c5a receptor in a nonmammalian ..
signaling through toll-like receptors triggers hiv-1 replication in latently infected mast cells
induction of a rapid and strong antigen-specific intraepithelial lymphocyte response during oral encephalitozoon cuniculi infection
subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response
the ly-6c high monocyte subpopulation transports listeria monocytogenes into the brain during systemic infection of mice
toll-like receptor 2 (tlr2)-dependent-positive and tlr2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans
preferential hla usage in the influenza virus-specific ctl response
hiv-specific cd8 + t cells exhibit markedly reduced levels of bcl-2 and bcl-x l
macrophage interactions with neutrophils regulate leishmania major infection
toll-like receptors are temporally involved in host defense
cd14 is an acute-phase protein
lysophosphatidic acid induces chemotaxis, oxygen radical production, cd11b up-regulation, ca 2+ mobilization, and actin reorganization in human eosinophils via pert..
o -methylated catechins from tea leaves inhibit multiple protein kinases in mast cells
neutrophil elastase (ne)-deficient mice demonstrate a nonredundant role for ne in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in..
immunization with glucose-6-phosphate isomerase induces t cell-dependent peripheral polyarthritis in genetically unaltered mice
deletion of the mouse meprin metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix
aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma
il-4-dependent th2 collateral priming to inhaled antigens independent of toll-like receptor 4 and myeloid differentiation factor 88
adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates nf- b-dependent inflammatory responses of human endothelial cells and macro..
complex role of the il-4 receptor in a murine model of airway inflammation: expression of the il-4 receptor on nonlymphoid cells of bone marrow origin contributes t..
monomeric recombinant tcr ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in sjl/j mice through cytokine switch
a self t cell epitope induces autoantibody response: mechanism for production of antibodies to diverse glomerular basement membrane antigens
multiepitope trojan antigen peptide vaccines for the induction of antitumor ctl and th immune responses
pregnancy-specific down-regulation of nf- b expression in t cells in humans is essential for the maintenance of the cytokine profile required for pregnancy success
mycobacterium tuberculosis resides in nonacidified vacuoles in endocytically competent alveolar macrophages from patients with tuberculosis and hiv infection
treatment of melanoma with 5-fluorouracil or dacarbazine in vitro sensitizes cells to antigen-specific ctl lysis through perforin/granzyme- and fas-mediated pathways
new loci from new zealand black and new zealand white on chromosomes 4 and 12 contribute to lupus-like disease in the context of balb/c
angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated t cells and induces th1 polarization
terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone mrl- fas lpr mice
recruitment of stat3 for production of il-10 by colon carcinoma cells induced by macrophage-derived il-6
human rhinovirus infection induces airway epithelial cell production of human -defensin 2 both in vitro and in vivo
regulation of t lymphocyte metabolism
cutting edge: the ontogeny and function of va14ja18 natural t lymphocytes require signal processing by protein kinase c and nf- b
cutting edge: early il-4 production governs the requirement for il-27-wsx-1 signaling in the development of protective th1 cytokine responses following leishmania m..
cutting edge: human cd4 + cd25 + t cells restrain the maturation and antigen-presenting function of dendritic cells
cutting edge: optical microspectrophotometry supports the existence of gel phase lipid rafts at the lamellipodium of neutrophils: apparent role in calcium signaling
cutting edge: ligation of the glucocorticoid-induced tnf receptor enhances autoreactive cd4 + t cell activation and experimental autoimmune encephalomyelitis
preferential activation of an il-2 regulatory sequence transgene in tcr and nkt cells: subset-specific differences in il-2 regulation
requirements for follicular exclusion and competitive elimination of autoantigen-binding b cells
b cell-dependent tcr diversification
macrophages and stromal cells phagocytose apoptotic bone marrow-derived b lineage cells
cellular flip long form-transgenic mice manifest a th2 cytokine bias and enhanced allergic airway inflammation
a toll-like receptor 2 ligand stimulates th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-fos in..
carbon monoxide produced by heme oxygenase-1 suppresses t cell proliferation via inhibition of il-2 production
feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive cd4 + cd25 + t regulatory cells
enhanced tumor responses to dendritic cells in the absence of cd8-positive cells
stat5 activation underlies il7 receptor-dependent b cell development
regulation of dendritic cell function by nk cells: mechanisms underlying the synergism in the combination therapy of il-12 and 4-1bb activation
analysis of mutational lineage trees from sites of primary and secondary ig gene diversification in rabbits and chickens
the novel cyclophilin binding compound, sanglifehrin a, disassociates g 1 cell cycle arrest from tolerance induction
cd40 ligation in vivo induces bystander proliferation of memory phenotype cd8 t cells
active protein kinase b regulates tcr responsiveness by modulating cytoplasmic-nuclear localization of nfat and nf- b proteins
costimulation of cd8 t cell responses by ox40
differential requirement for the cd40-cd154 costimulatory pathway during th cell priming by cd8 + and cd8 − murine dendritic cell subsets
cytokine dysregulation induced by apoptotic cells is a shared characteristic of macrophages from nonobese diabetic and systemic lupus erythematosus-prone mice
simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer
the inositol 3-phosphatase pten negatively regulates fc receptor signaling, but supports toll-like receptor 4 signaling in murine peritoneal macrophages
pax-5 is essential for sterile transcription during ig chain gene rearrangement
listeriolysin o from listeria monocytogenes is a lymphocyte apoptogenic molecule
activated primary and memory cd8 t cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin
burn injury initiates a shift in superantigen-induced t cell responses and host survival
ctla-4 blockage increases resistance to infection with the intracellular protozoan trypanosoma cruzi
a leucine-rich repeat motif of leishmania parasite surface antigen 2 binds to macrophages through the complement receptor 3
selective impairments in dendritic cell-associated function distinguish hepatitis c virus and hiv infection
timed ablation of regulatory cd4 + t cells can prevent murine aids progression
malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a toll-like receptor 9-dependent pathway
effective targeting of pathogens to neutrophils via chimeric surfactant protein d/anti-cd89 protein
ifn- induces gp91 phox expression in human monocytes via protein kinase c-dependent phosphorylation of pu.1
janus kinase 3 down-regulates lipopolysaccharide-induced il-1 -converting enzyme activation by autocrine il-10
triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival
mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets
differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/cc chemokine ligand 22) by the d6 decoy r..
toll-like receptor (tlr)2 and tlr4 agonists regulate ccr expression in human monocytic cells
a novel p2x 7 receptor activator, the human cathelicidin-derived peptide ll37, induces il-1 processing and release
transient corticosteroid treatment permanently amplifies the th2 response in a murine model of asthma
overexpression of serum amyloid a-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21 waf-1/cip-1/sdi-..
flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation
helicobacter pylori -specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection
cxcl1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-a
does hla-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis?
strain distribution pattern of susceptibility to immune-mediated nephritis
human intestinal microvascular endothelial cells express toll-like receptor 5: a binding partner for bacterial flagellin
matrix metalloproteinases as targets for the immune system during experimental arthritis
thymocyte-intrinsic genetic factors influence cd8 t cell lineage commitment and affect selection of a tumor-reactive tcr
a novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in new zealand mice when crossed with balb/c
b cell selection defects underlie the development of diabetogenic apcs in nonobese diabetic mice
identification of multiple hla-dr-restricted epitopes of the tumor-associated antigen camel by cd4 + th1/th2 lymphocytes
thalidomide induces apoptosis in human monocytes by using a cytochrome c -dependent pathway
hla-b27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone bip
increased cd8 + cytotoxic t cell responses to myelin basic protein in multiple sclerosis