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免疫学杂志2003年第09期封面 购买


cutting edge: h-2dm is responsible for the large differences in presentation among peptides selected by i-a k during antigen processing
cutting edge: cross-presentation as a mechanism for efficient recruitment of tumor-specific ctl to the brain
cutting edge: expansion of the kir locus by unequal crossing over
selective targeting of melanoma and apcs using a recombinant antibody with tcr-like specificity directed toward a melanoma differentiation antigen
lymphoid precursors in intestinal cryptopatches express ccr6 and undergo dysregulated development in the absence of ccr6
microglia-mediated nitric oxide cytotoxicity of t cells following amyloid -peptide presentation to th1 cells
cd28 engagement promotes actin polymerization through the activation of the small rho gtpase cdc42 in human t cells
mhc recognition by hapten-specific hla-a2-restricted cd8 + ctl
in vivo, dendritic cells can cross-present virus-like particles using an endosome-to-cytosol pathway
rapid high efficiency sensitization of cd8 + t cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through ..
tnf skews monocyte differentiation from macrophages to dendritic cells
systemic overexpression of il-10 induces cd4 + cd25 + cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion
cd4 + th cells resembling regulatory t cells that inhibit chronic colitis differentiate in the absence of interactions between cd4 and class ii mhc
regulation of sustained actin dynamics by the tcr and costimulation as a mechanism of receptor localization
surface expression of notch1 on thymocytes: correlation with the double-negative to double-positive transition
human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating fas-fas ligand system
dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease
cpg dna induces a class ii transactivator-independent increase in class ii mhc by stabilizing class ii mhc mrna in b lymphocytes
the decline in b lymphopoiesis in aged mice reflects loss of very early b-lineage precursors
analysis of h2-o influence on antigen presentation by b cells
interaction of murine precursor b cell receptor with stroma cells is controlled by the unique tail of 5 and stroma cell-associated heparan sulfate
allele-specific expression of the il-1 gene in human cd4 + t cell clones
two distinct mechanisms for induction of dendritic cell apoptosis in response to intact streptococcus pneumoniae
dendritic cells mediate nk cell help for th1 and ctl responses: two-signal requirement for the induction of nk cell helper function
regulation of the class ii mhc pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor
cholera toxin promotes the induction of regulatory t cells specific for bystander antigens by modulating dendritic cell activation
a transgenic mouse model genetically tags all activated cd8 t cells
the fas/fas ligand pathway is important for optimal tumor regression in a mouse model of ctl adoptive immunotherapy of experimental cms4 lung metastases
most il-4-producing thymocytes of adult mice originate from fetal precursors
b220 + double-negative t cells suppress polyclonal t cell activation by a fas-independent mechanism that involves inhibition of il-2 production
tcr binding kinetics measured with mhc class i tetramers reveal a positive selecting peptide with relatively high affinity for tcr
suppressor of cytokine signaling 1 regulates il-15 receptor signaling in cd8 + cd44 high memory t lymphocytes
differential c-myc responsiveness to b cell receptor ligation in b cell-negative selection
adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of tnf- tolerance
molecular cloning of c4 gene and identification of the class iii complement region in the shark mhc
t cell recognition of distinct peptide:i-a u conformers in murine experimental autoimmune encephalomyelitis
regulation of the human high affinity ige receptor -chain gene expression via an intronic element
functional requirements for interactions between cd84 and src homology 2 domain-containing proteins and their contribution to human t cell activation
tcr mrna with an alternatively spliced 3‘-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of tcr and tcr/cd3 com..
the block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of dna double stran..
effect of promoter methylation on the regulation of ifn- gene during in vitro differentiation of human peripheral blood t cells into a th2 population
spontaneous membrane transfer through homotypic synapses between lymphoma cells
ifn- -producing t cells help control murine west nile virus infection
membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group a streptococcus
prime-boost vaccination with hiv-1 gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral a..
epitope-enhanced conserved hiv-1 peptide protects hla-a2-transgenic mice against virus expressing hiv-1 antigen
intracellular mediators of granulysin-induced cell death
francisella tularensis selectively induces proinflammatory changes in endothelial cells
cd1d-restricted nkt cells express a chemokine receptor profile indicative of th1-type inflammatory homing cells
functional plasticity of dendritic cell subsets as mediated by cd40 versus b7 activation
overlapping and selective roles of endothelial intercellular adhesion molecule-1 (icam-1) and icam-2 in lymphocyte trafficking
c1 inhibitor prevents endotoxin shock via a direct interaction with lipopolysaccharide 1,
blockade of s100a8 and s100a9 suppresses neutrophil migration in response to lipopolysaccharide
apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
unique effect of arachidonic acid on human neutrophil tnf receptor expression: up-regulation involving protein kinase c, extracellular signal-regulated kinase, and ..
inhibition of rho family gtpases results in increased tnf- production after lipopolysaccharide exposure
anaphylatoxin c5a induces monocyte recruitment and differentiation into dendritic cells by tnf- and prostaglandin e 2 -dependent mechanisms
m-csf induces vascular endothelial growth factor production and angiogenic activity from human monocytes
regulation of eosinophilopoiesis in a murine model of asthma
immunoregulatory role of ocular macrophages: the macrophages produce rantes to suppress experimental autoimmune uveitis
coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans 1,
most highly exposed seronegative men lack hiv-1-specific, ifn- -secreting t cells
therapeutic attenuation of pulmonary fibrosis via targeting of il-4- and il-13-responsive cells
genomic effects of ifn- in multiple sclerosis patients
activation of cutaneous protein kinase c induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways
definition of tcr epitopes for ctl-mediated attack of cutaneous t cell lymphoma
single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the b cell response in multiple sclerosis cerebrospinal fluid
diversity in intrinsic strengths of the human complement system: serum c4 protein concentrations correlate with c4 gene size and polygenic variations, hemolytic act..
cutting edge: requirement for growth hormone-releasing hormone in the development of experimental autoimmune encephalomyelitis
cutting edge: a possible role for cd4 + thymic macrophages as professional scavengers of apoptotic thymocytes
cutting edge: multiple autoimmune pathways in kd/kd mice
notch2 haploinsufficiency results in diminished b1 b cells and a severe reduction in marginal zone b cells
role of trail and ifn- in cd4 + t cell-dependent tumor rejection in the anterior chamber of the eye
ccl9 is secreted by the follicle-associated epithelium and recruits dome region peyers patch cd11b + dendritic cells
expression and functional importance of collagen-binding integrins, 1 1 and 2 1, on virus-activated t cells
cxcr3 is induced early on the pathway of cd4 + t cell differentiation and bridges central and peripheral functions 1,
modeling tcr signaling complex formation in positive selection
sustained response initiation is required for t cell clonal expansion but not for effector or memory development in vivo
a failure to repair self-proteins leads to t cell hyperproliferation and autoantibody production
involvement of inducible costimulator-b7 homologous protein costimulatory pathway in murine lupus nephritis
ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site
infectious nickel tolerance: a reciprocal interplay of tolerogenic apcs and t suppressor cells that is driven by immunization
genetic control of nkt cell numbers maps to major diabetes and lupus loci
inducible expression of macrophage receptor marco by dendritic cells following phagocytic uptake of dead cells uncovered by oligonucleotide arrays
activating and inhibitory ly49 receptors modulate nk cell chemotaxis to cxc chemokine ligand (cxcl) 10 and cxcl12
notch signaling augments t cell responsiveness by enhancing cd25 expression
phenotypic and functional characterization of long-term cultured rhesus macaque spleen-derived nkt cells
in vitro generation and life span extension of human papillomavirus type 16-specific, healthy donor-derived ctl clones
recombinant cd63/me491/neuroglandular/nki/c-3 antigen inhibits growth of established tumors in transgenic mice
an il-2-dependent switch between cd95 signaling pathways sensitizes primary human t cells toward cd95-mediated activation-induced cell death
assessment of requirements for il-15 and ifn regulatory factors in uterine nk cell differentiation and function during pregnancy
alterations in the expression of mhc class i glycoproteins by b16bl6 melanoma cells modulate insulin receptor-regulated signal transduction and augments resistance ..
in vivo antitumor activity of nkt cells activated by the combination of il-12 and il-18
differential chemokine responses and homing patterns of murine tcr nkt cell subsets
enhancing dna vaccine potency by combining a strategy to prolong dendritic cell life with intracellular targeting strategies
identification of a novel subpopulation of human cord blood cd34 - cd133 - cd7 - cd45 + lineage - cells capable of lymphoid/nk cell differentiation after in vitro e..
the wd motif-containing protein rack-1 functions as a scaffold protein within the type i ifn receptor-signaling complex
in vivo impact of cpg1826 oligodeoxynucleotide on cd8 t cell primary responses and survival
tcr comodulation of nonengaged tcr takes place by a protein kinase c and cd3 di-leucine-based motif-dependent mechanism
generation and function of reactive oxygen species in dendritic cells during antigen presentation
tcr-mediated notch signaling regulates proliferation and ifn- production in peripheral t cells
differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive t cell hybridoma clo..
characterization of the cd200 receptor family in mice and humans and their interactions with cd200
candida albicans induces selectively transcriptional activation of cyclooxygenase-2 in hela cells: pivotal roles of toll-like receptors, p38 mitogen-activated prote..
killer cell ig-like receptor and leukocyte ig-like receptor transgenic mice exhibit tissue- and cell-specific transgene expression
tax and m1 peptide/hla-a2-specific fabs and t cell receptors recognize nonidentical structural features on peptide/hla-a2 complexes
herpes simplex virus type 1 targets the mhc class ii processing pathway for immune evasion
dominating ige-binding epitope of bet v 1, the major allergen of birch pollen, characterized by x-ray crystallography and site-directed mutagenesis
immunoglobulin µ heavy chains do not mediate tyrosine phosphorylation of ig from the er- cis- golgi
measles virus infection induces chemokine synthesis by neurons
reactivation of latent tuberculosis infection in tnf-deficient mice
toll-like receptor 4-mediated innate il-10 activates antigen-specific regulatory t cells and confers resistance to bordetella pertussis by inhibiting inflammatory p..
dynamics of macrophage cell populations during murine pulmonary tuberculosis
over-expression of bcl-2 provides protection in septic mice by a trans effect
il-10 prevents liver necrosis during murine infection with trichinella spiralis
successful induction of cd8 t cell-dependent protection against malaria by sequential immunization with dna and recombinant poxvirus of neonatal mice born to immune..
subcellular localization of toll-like receptor 3 in human dendritic cells
hla class ii-restricted cd4 + t cell responses directed against influenza viral antigens postinfluenza vaccination
v 4 + t cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice
identification of tissue transglutaminase as a novel molecule involved in human cd8 + t cell transendothelial migration
experimental evidence for lack of homodimerization of the g protein-coupled human n -formyl peptide receptor
il-6 induces nf- b activation in the intestinal epithelia
soluble il-6 receptor governs il-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 13
b cell deficiency confers protection from renal ischemia reperfusion injury
lipid raft localization of cell surface e-selectin is required for ligation-induced activation of phospholipase c
hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with -actinin 4
crucial role of il-4/stat6 in t cell-mediated hepatitis: up-regulating eotaxins and il-5 and recruiting leukocytes
glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands
cytokine polymorphisms and histologic expression in autopsy studies: contribution of tnf- and tgf- 1 to the pathogenesis of autoimmune-associated congenital heart b..
cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
successful allogeneic neonatal bone marrow transplantation devoid of myeloablation requires costimulatory blockade
betulinic acid suppresses carcinogen-induced nf- b activation through inhibition of i b kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix me..
high efficiency tcr gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognit..
fc riia is expressed on natural ifn- -producing cells (plasmacytoid dendritic cells) and is required for the ifn- production induced by apoptotic cells combined wit..
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