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免疫学杂志2003年第05期封面 购买


cutting edge: cd8 + effector t cells reject tumors by direct antigen recognition but indirect action on host cells
cutting edge: roles of toll-like receptor 4 and il-23 in il-17 expression in response to klebsiella pneumoniae infection
cutting edge: conventional cd8 + dendritic cells are preferentially involved in ctl priming after footpad infection with herpes simplex virus-1
a pyrazole derivative, ym-58483, potently inhibits store-operated sustained ca 2+ influx and il-2 production in t lymphocytes
decorin reverses the repressive effect of autocrine-produced tgf- on mouse macrophage activation
il-6 production by pulmonary dendritic cells impedes th1 immune responses
activation with cpg-a and cpg-b oligonucleotides reveals two distinct regulatory pathways of type i ifn synthesis in human plasmacytoid dendritic cells
phosphatidylinositol 3-kinase regulates the cd4/cd8 t cell differentiation ratio
glatiramer acetate (copolymer-1, copaxone) promotes th2 cell development and increased il-10 production through modulation of dendritic cells
distinct pathways for nf- b regulation are associated with aberrant macrophage il-12 production in lupus- and diabetes-prone mouse strains
determinants of human b cell migration across brain endothelial cells
homology between an alloantigen and a self mhc allele calibrates the avidity of the alloreactive t cell repertoire independent of tcr affinity
correction of defects responsible for impaired qa-2 class ib mhc expression on melanoma cells protects mice from tumor growth
il-7-regulated homeostatic maintenance of recent thymic emigrants in association with caspase-mediated cell proliferation and apoptotic cell death
study of the mechanism of tcr antagonism using dual-tcr-expressing t cells
src homology region 2-containing protein tyrosine phosphatase-2 (shp-2) can play a direct role in the inhibitory function of killer cell ig-like receptors in human ..
murine neonatal lymphocytes show rapid early cell cycle entry and cell division
allelic exclusion of the tcr -chain is an active process requiring tcr-mediated signaling and c-cbl
b1 cells contribute to serum igm, but not to intestinal iga, production in gnotobiotic ig allotype chimeric mice
tgf- 1 suppresses myeloid fc receptor function by regulating the expression and function of the common -subunit
the cyclopentenone-type prostaglandin 15-deoxy- 12,14 -prostaglandin j 2 inhibits cd95 ligand gene expression in t lymphocytes: interference with promoter activatio..
enforced bcl-x l gene expression restored splenic b lymphocyte development in baff-r mutant mice
influenza a virus infection inhibits the efficient recruitment of th2 cells into the airways and the development of airway eosinophilia
tgf- 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes
cd5 inhibits signaling at the immunological synapse without impairing its formation
ikk is required for peripheral b cell survival and proliferation
naive t cell recruitment to nonlymphoid tissues: a role for endothelium-expressed cc chemokine ligand 21 in autoimmune disease and lymphoid neogenesis
a role of cxc chemokine ligand 12/stromal cell-derived factor-1/pre-b cell growth stimulating factor and its receptor cxcr4 in fetal and adult t cell development in..
maternal autoantibody triggers de novo t cell-mediated neonatal autoimmune disease
endogenous il-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways
the paradox of immune molecular recognition of -galactosylceramide: low affinity, low specificity for cd1d, high affinity for tcrs
point mutations in or near the antigen-binding groove of hla-dr3 implicate class ii-associated invariant chain peptide affinity as a constraint on mhc class ii poly..
absence of cc chemokine ligand 2 results in an altered th1/th2 cytokine balance and failure to expel trichuris muris infection
origin of mannose-binding lectin-associated serine protease (masp)-1 and masp-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus..
retrocyclin, an antiretroviral -defensin, is a lectin
cpg oligodeoxynucleotides protect normal and siv-infected macaques from leishmania infection
il-1 receptor type 1 gene-deficient mice demonstrate an impaired host defense against pneumococcal meningitis
il-12 receptor 1 and toll-like receptor 4 increase il-1 - and il-18-associated myocarditis and coxsackievirus replication
microsomal prostaglandin e synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin e 2 production i..
mitochondrial potential and reactive oxygen intermediates in antigen-specific cd8 + t cells during viral infection
12 -prostaglandin j 2, a plasma metabolite of prostaglandin d 2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis
il-1-driven endogenous il-10 production protects against the systemic and local acute inflammatory response following intestinal reperfusion injury
tyrosine phosphorylation of i- b kinase / by protein kinase c-dependent c-src activation is involved in tnf- -induced cyclooxygenase-2 expression
ifn- gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis
necroinflammatory liver disease in balb/c background, tgf- 1-deficient mice requires cd4 + t cells
albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis
transfer of severe experimental autoimmune encephalomyelitis by il-12- and il-18-potentiated t cells is estrogen sensitive
cc chemokine ligand 1 promotes recruitment of eosinophils but not th2 cells during the development of allergic airways disease
differential contribution of il-4 and stat6 vs stat4 to the development of lupus nephritis
the naive b cell repertoire predisposes to antigen-induced systemic lupus erythematosus
inhibition of ifn- signaling by glucocorticoids
phosphatidylserine on hiv envelope is a cofactor for infection of monocytic cells
complementarity-determining region 3 spectratyping analysis of the tcr repertoire in multiple sclerosis
design, construction, and in vitro analyses of multivalent antibodies
cryptic ctl epitope on a murine sarcoma meth a generated by exon extension as a novel mechanism
cutting edge: the nk cell receptor 2b4 augments antigen-specific t cell cytotoxicity through cd48 ligation on neighboring t cells
cutting edge: role of il-27/wsx-1 signaling for induction of t-bet through activation of stat1 during initial th1 commitment
cutting edge: dependence of tcr antagonism on src homology 2 domain-containing protein tyrosine phosphatase activity
environmental chemical-induced pro/pre-b cell apoptosis: analysis of c-myc, p27 kip1, and p21 waf1 reveals a death pathway distinct from clonal deletion
induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific cd8 t cells
two regions of down-regulation in the ige-mediated signaling pathway in human basophils
the lymphoid past of mouse plasmacytoid cells and thymic dendritic cells
regulation of cd8 + t cells undergoing primary and secondary responses to infection in the same host
prostaglandin d 2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive th cells
differential roles of cb1 and cb2 cannabinoid receptors in mast cells
stochastic model of t cell proliferation: a calculus revealing il-2 regulation of precursor frequencies, cell cycle time, and survival
active form of notch members can enforce t lymphopoiesis on lymphoid progenitors in the monolayer culture specific for b cell development
histone deacetylation, but not hypermethylation, modifies class ii transactivator and mhc class ii gene expression in squamous cell carcinomas
differential control of cell cycle, proliferation, and survival of primary t lymphocytes by purine and pyrimidine nucleotides
mechanisms of accelerated immune-mediated diabetes resulting from islet cell expression of a fas ligand transgene
il-18 and il-12 signal through the nf- b pathway to induce nk-1r expression on t cells
superantigen-induced regulatory t cells display different suppressive functions in the presence or absence of natural cd4 + cd25 + regulatory t cells in vivo
il-15 promotes the survival of naive and memory phenotype cd8 + t cells
a peptide from heat shock protein 60 is the dominant peptide bound to qa-1 in the absence of the mhc class ia leader sequence peptide qdm
extracellular matrix conditions t cells for adhesion to tissue interstitium
mast cells express novel functional il-15 receptor isoforms
attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase itk
nitric oxide-independent ctl suppression during tumor progression: association with arginase-producing (m2) myeloid cells
early il-2 production by mouse dendritic cells is the result of microbial-induced priming
tnf enhances cd4 + t cell alloproliferation, ifn- responses, and intestinal graft-versus-host disease by il-12-independent mechanisms
a subset of human dendritic cells in the t cell area of mucosa-associated lymphoid tissue with a high potential to produce tnf-
repertoire shift in the humoral response to phosphocholine-keyhole limpet hemocyanin: v h somatic mutation in germinal center b cells impairs t15 ig function
prevalent role of tcr -chain in the selection of the preimmune repertoire specific for a human tumor-associated self-antigen
decreased binding of peptides-mhc class i (pmhc) multimeric complexes to cd8 affects their binding avidity for the tcr but does not significantly impact on pmhc/tcr..
molecular identification and functional expression of µ 3, a novel alternatively spliced variant of the human µ opiate receptor gene
dna methylation and chromatin structure regulate t cell perforin gene expression
the h4 b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications
selective regulation of mature igg1 transcription by cd86 and 2 -adrenergic receptor stimulation
the relative contribution of il-4 receptor signaling and il-10 to susceptibility to leishmania major
toll-like receptor 2 (tlr2) and tlr9 signaling results in hiv-long terminal repeat trans -activation and hiv replication in hiv-1 transgenic mouse spleen cells: imp..
the toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells
the induction of hiv gag-specific cd8 + t cells in the spleen and gut-associated lymphoid tissue by parenteral or mucosal immunization with recombinant listeria mon..
a single heteroclitic epitope determines cancer immunity after xenogeneic dna immunization against a tumor differentiation antigen
monocyte-derived dendritic cells generated after a short-term culture with ifn- and granulocyte-macrophage colony-stimulating factor stimulate a potent epstein-barr..
cumulative toll-like receptor activation in human macrophages treated with whole bacteria
the lymphotoxin receptor is critically involved in controlling infections with the intracellular pathogens mycobacterium tuberculosis and listeria monocytogenes
macrophages restrict pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx, and balance pro- and anti-inflammatory cytokines in balb/c mice
neutrophilia in lfa-1-deficient mice confers resistance to listeriosis: possible contribution of granulocyte-colony-stimulating factor and il-17
chemotactic factor-induced recruitment and activation of tec family kinases in human neutrophils. ii. effects of lfm-a13, a specific btk inhibitor
duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo
c-c chemokine ligand 2/monocyte chemoattractant protein-1 directly inhibits nkt cell il-4 production and is hepatoprotective in t cell-mediated hepatitis in the mouse
different modes of il-10 and tgf- to inhibit cytokine-dependent ifn- production: consequences for reversal of lipopolysaccharide desensitization
selective roles for toll-like receptor (tlr)2 and tlr4 in the regulation of neutrophil activation and life span
calcium-independent phospholipase a 2 is required for lysozyme secretion in u937 promonocytes
amyloid peptide-induced cytokine and chemokine expression in thp-1 monocytes is blocked by small inhibitory rna duplexes for early growth response-1 messenger rna
peroxisome proliferator-activated receptor inhibits the migration of dendritic cells: consequences for the immune response
akt phosphorylates p47 phox and mediates respiratory burst activity in human neutrophils
expression and production of the cxc chemokine growth-related oncogene- by human eosinophils
hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens i..
immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies
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