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《临床研究杂志》2006年第04期

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in this issue
rescuing the nih before it is too late
darwin an exhibition at the american museum of natural history
twenty-first century plague
harnessing preclinical mouse models to inform human clinical cancer trials
childhood lead poisoning: the torturous path from science to policy
adult t cell leukemia: a tale of two t cells
cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify
ontogeny of adrenal steroid biosynthesis: why girls will be girls
pathomechanisms in rheumatoid arthritis ― time for a string theory?
a new cardiac master switch for the renin-angiotensin system
oxidative stress in sepsis: a redox redux
the alchemy of tendon repair: a primer for the (s)mad scientist
identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin d receptor modulators
disease-associated mutations affect intracellular traffic and paracellular mg2+ transport function of claudin-16
induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis
yeast zymosan, a stimulus for tlr2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance
neotendon formation induced by manipulation of the smad8 signalling pathway in mesenchymal stem cells
in humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development
gata-6 regulates semaphorin 3c and is required in cardiac neural crest for cardiovascular morphogenesis
antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
htlv-1 propels untransformed cd4+ lymphocytes into the cell cycle while protecting cd8+ cells from death
treg-mediated immunosuppression involves activation of the notch-hes1 axis by membrane-bound tgf-?
1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload
induction of myasthenia by immunization against muscle-specific kinase
cd137-mediated immunotherapy for allergic asthma
nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
insulin resistance reduces arterial prostacyclin synthase and enos activities by increasing endothelial fatty acid oxidation
immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of cns autoimmunity
essential role of tnf family molecule light as a cytokine in the pathogenesis of hepatitis
intestinal abca1 directly contributes to hdl biogenesis in vivo
cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion
convergence of itch-induced ubiquitination with mekk1-jnk signaling in th2 tolerance and airway inflammation
an unexpected role for angiotensin ii in the link between dietary salt and proximal reabsorption
farnesoid x receptor is essential for normal glucose homeostasis
the neutrophil-activating protein of helicobacter pylori promotes th1 immune responses
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