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核酸研究医学期刊2008年第01期封面 购买


the ercc1/xpf endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
rna secondary structure regulates the translation of sxy and competence development in haemophilus influenzae
dynamic structures of bacillus subtilis recn–dna complexes
distinct hdacs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to trichostatin a and 1,25-dihydroxyvitamin d
the c-terminal domain of escherichia coli hfq is required for regulation
genomic distribution and functional analyses of potential g-quadruplex-forming sequences in saccharomyces cerevisiae
characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent dna base analogue
the eif4g homolog dap5/p97 supports the translation of select mrnas during endoplasmic reticulum stress
smad3 prevents binding of nkx2.1 and foxa1 to the spb promoter through its mh1 and mh2 domains
genome-wide location analysis and expression studies reveal a role for p110 cux1 in the activation of dna replication genes
identification of functional domains in arabidopsis thaliana mrna decapping enzyme (atdcp2)
mapping the phase diagram of the writhe of dna nanocircles using atomistic molecular dynamics simulations
nucleolin regulates c-jun/sp1-dependent transcriptional activation of cpla 2 in phorbol ester-treated non-small cell lung cancer a549 cells
incorporation of extracellular 8-oxodg into dna and rna requires purine nucleoside phosphorylase in mcf-7 cells
ex vivo correction of selenoprotein n deficiency in rigid spine muscular dystrophy caused by a mutation in the selenocysteine codon
the rna polymerase factory: a robotic in vitro assembly platform for high-throughput production of recombinant protein complexes
dna oligonucleotides with a, t, g or c opposite an abasic site: structure and dynamics
sumo1 negatively regulates brca1-mediated transcription, via modulation of promoter occupancy
dehydration, deamination and enzymatic repair of cytosine glycols from oxidized poly(dg-dc) and poly(di-dc)
measurement of the salt-dependent stabilization of partially open dna by escherichia coli ssb protein
the presence of the tar rna structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (hiv-1) by modifying the r..
unconventional giy-yig homing endonuclease encoded in group i introns in closely related strains of the bacillus cereus group
two rna editing sites with cis -acting elements of moderate sequence identity are recognized by an identical site-recognition protein in tobacco chloroplasts
roles for tbdss-1 in rna surveillance and decay of maturation by-products from the 12s rrna locus
cpg methylation plays a vital role in determining tissue- and cell-specific expression of the human cell-death-inducing dff45-like effector a gene through the regul..
activation of dna strand exchange by cationic comb-type copolymers: effect of cationic moieties of the copolymers
mutation of the arginine finger in the active site of escherichia coli dbpa abolishes atpase and helicase activity and confers a dominant slow growth phenotype
nuclear receptor interaction protein, a coactivator of androgen receptors (ar), is regulated by ar and sp1 to feed forward and activate its own gene expression thro..
mismatch repair proteins are recruited to replicating dna through interaction with proliferating cell nuclear antigen (pcna)
mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells
the process of displacing the single-stranded dna-binding protein from single-stranded dna by reco and recr proteins
the arabidopsis information resource (tair): gene structure and function annotation
phosphat : a database of phosphorylation sites in arabidopsis thaliana and a plant-specific phosphorylation site predictor
jaspar, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update
oryza tag line, a phenotypic mutant database for the génoplante rice insertion line library
the rice annotation project database (rap-db): 2008 update
gdr (genome database for rosaceae): integrated web-database for rosaceae genomics and genetics data
panzea: an update on new content and features
shanghai rapeseed database: a resource for functional genomics studies of seed development and fatty acid metabolism of brassica
mugen mouse database; animal models of human immunological diseases
oreganno: an open-access community-driven resource for regulatory annotation
protisa: a comprehensive resource for translation initiation site annotation in prokaryotic genomes
regulondb (version 6.0): gene regulation model of escherichia coli k-12 beyond transcription, active (experimental) annotated promoters and textpresso navigation
transfactomedb: a resource for exploring the nucleotide sequence specificity and condition-specific regulatory activity of trans -acting factors
database resources of the national center for biotechnology information
yeastract-discoverer: new tools to improve the analysis of transcriptional regulatory associations in saccharomyces cerevisiae
ared organism: expansion of ared reveals au-rich element cluster variations between human and mouse
grsdb2 and grs_utrdb: databases of quadruplex forming g-rich sequences in pre-mrnas and mrnas
the microrna.org resource: targets and expression
mirbase: tools for microrna genomics
mirgator: an integrated system for functional annotation of micrornas
mirnamap 2.0: genomic maps of micrornas in metazoan genomes
noncode v2.0: decoding the non-coding
pirnabank: a web resource on classified and clustered piwi-interacting rnas
the 3d rrna modification maps database: with interactive tools for ribosome analysis
vir-mir db: prediction of viral microrna candidate hairpins
the universal protein resource (uniprot)
mips: analysis and annotation of genome information in 200
the molecular biology database collection: 2008 update
aaindex: amino acid index database, progress report 200
cybase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering
malisam: a database of structurally analogous motifs in proteins
megamotifbase: a database of structural motifs in protein families and superfamilies
ddbj with new system and face
ppt-db: the protein property prediction and testing database
locate: a mammalian protein subcellular localization database
topdb: topology data bank of transmembrane proteins
phospho.elm: a database of phosphorylation sites—update 200
the 20 years of prosite
eggnog: automated construction and annotation of orthologous groups of genes
epgd: a comprehensive web resource for integrating and displaying eukaryotic paralog/paralogon information
inparanoid 6: eukaryotic ortholog clusters with inparalogs
optic: orthologous and paralogous transcripts in clades
orthodb: the hierarchical catalog of eukaryotic orthologs
pairsdb atlas of protein sequence space
the pfam protein families database
simap—structuring the network of protein similarities
atdb: a uni-database platform for animal toxins
chromdb: the chromatin database
db-pabp: a database of polyanion-binding proteins
development of a heme protein structure–electrochemical function database
gissd: group i intron sequence and structure database
knottin: the knottin or inhibitor cystine knot scaffold in 200
merops: the peptidase database
norine: a database of nonribosomal peptides
selenodb 1.0 : a database of selenoprotein genes, proteins and secis elements
the telomerase database
chebi: a database and ontology for chemical entities of biological interest
chembank : a small-molecule screening and cheminformatics resource database
r.e.dd.b.: a database for resp and esp atomic charges, and force field libraries
glycoconjugate data bank:structures—an annotated glycan structure database and n -glycan primary structure verification service
greglist: a database listing potential g-quadruplex regulated genes
the its2 database ii: homology modelling rna structure for molecular systematics
the gypsy database (gydb) of mobile genetic elements
quadbase: genome-wide database of g4 dna—occurrence and conservation in human, chimpanzee, mouse and rat promoters and 146 microbes
rna frabase version 1.0: an engine with a database to search for the three-dimensional fragments within rna structures
rnajunction: a database of rna junctions and kissing loops for three-dimensional structural analysis and nanodesign
autopsi: a database for automatic structural classification of protein sequences and structures
colisnp database server mapping nssnps on protein structures
gene3d: comprehensive structural and functional annotation of genomes
data growth and its impact on the scop database: new developments
remediation of the protein data bank archive
funsimmat: a comprehensive functional similarity database
the gene ontology project in 200
the hgnc database in 2008: a resource for the human genome
the plant ontology database: a community resource for plant structure and developmental stages controlled vocabulary and annotations
idbd: infectious disease biomarker database
supercat: a supertree database for combined and integrative multilocus sequence typing analysis of the bacillus cereus group of bacteria (including b. cereus, b. an..
genolist: an integrated environment for comparative analysis of microbial genomes
transpogene and microtranspogene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates
the genomes on line database (gold) in 2007: status of genomic and metagenomic projects and their associated metadata
kegg for linking genomes to life and the environment
narcisse: a mirror view of conserved syntenies
phylomedb: a database for genome-wide collections of gene phylogenies
biohealthbase: informatics support in the elucidation of influenza virus host–pathogen interactions and virulence
priorities for nucleotide trace, sequence and annotation data capture at the ensembl trace archive and the embl nucleotide sequence database
covdb: a comprehensive database for comparative analysis of coronavirus genes and genomes
the hepatitis c sequence database in los alamos
alterorf: a database of alternate open reading frames
enteropathogen resource integration center (eric): bioinformatics support for research on biodefense-relevant enterobacteria
heg-db: a database of predicted highly expressed genes in prokaryotic complete genomes under translational selection
the integrated microbial genomes (img) system in 2007: data content and analysis tool extensions
ugmicrosat db : database for mining microsatellites from unigenes
img/m: a data management and analysis system for metagenomes
vfdb 2008 release: an enhanced web-based resource for comparative pathogenomics
x base2: a comprehensive resource for comparative bacterial genomics
protozoadb: dynamic visualization and exploration of protozoan genomes
toxodb: an integrated toxoplasma gondii database resource
candidadb: a multi-genome database for candida species and related saccharomycotina
cfgp: a web-based, comparative fungal genomics platform
utrome.org: a platform for 3‘utr biology in c. elegans
phi-base update: additions to the pathogen–host interaction database
gene ontology annotations at sgd: new data sources and annotation methods
butterflybase: a platform for lepidopteran genomics
flybase: integration and improvements to query tools
redfly 2.0: an integrated database of cis -regulatory modules and transcription factor binding sites in drosophila
smedgd: the schmidtea mediterranea genome database
upgrades to stellabase facilitate medical and genetic studies on the starlet sea anemone, nematostella vectensis
wormbase 200
procognate: a cognate ligand domain mapping for enzymes
the metacyc database of metabolic pathways and enzymes and the biocyc collection of pathway/genome databases
prosas: a database for analyzing alternative splicing in the context of protein structures
bacteriome.org—an integrated protein interaction database for e. coli
the biogrid interaction database: 2008 update
the cell cycle db: a systems biology approach to cell cycle analysis
corum: the comprehensive resource of mammalian protein complexes
dima 2.0—predicted and known domain interactions
domine: a database of protein domain interactions
hotsprint: database of computational hot spots in protein interfaces
ligasite—a database of biologically relevant binding sites in proteins with known apo -structures
binding moad, a high-quality protein–ligand database
pepcyber:p pep: a database of human protein–protein interactions mediated by phosphoprotein-binding domains
stitch: interaction networks of chemicals and proteins
endonet: an information resource about regulatory networks of cell-to-cell communication
cmgsdb: integrating heterogeneous caenorhabditis elegans data sources using compositional data mining
networkin: a resource for exploring cellular phosphorylation networks
the molecule pages database
ensembl 200
europhenome and empress: online mouse phenotyping resource
gallus gbrowse: a unified genomic database for the chicken
the mouse genome database (mgd): mouse biology and model systems
pbmice: an integrated database system of piggybac (pb) insertional mutations and their characterizations in mice
treefam: 2008 update
the unitrap resource: tools for the biologist enabling optimized use of gene trap clones
utgb/medaka: genomic resource database for medaka biology
the vertebrate genome annotation (vega) database
xenbase: a xenopus biology and genomics resource
the zebrafish information network: the zebrafish model organism database provides expanded support for genotypes and phenotypes
coxpresdb: a database of coexpressed gene networks in mammals
the ucsc genome browser database: 2008 update
x:map: annotation and visualization of genome structure for affymetrix exon array analysis
evola: ortholog database of all human genes in h-invdb with manual curation of phylogenetic trees
the h-invitational database (h-invdb), a comprehensive annotation resource for human genes and transcripts
human paml browser: a database of positive selection on human genes using phylogenetic methods
msy breakpoint mapper, a database of sequence-tagged sites useful in defining naturally occurring deletions in the human y chromosome
mutdb: update on development of tools for the biochemical analysis of genetic variation
f-snp: computationally predicted functional snps for disease association studies
joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the snpeffect and pupasuite databases
cangem: mining gene copy number changes in cancer
methycancer: the database of human dna methylation and cancer
pubmeth: a cancer methylation database combining text-mining and expert annotation
4d xpress : a database for cross-species expression pattern comparisons
cyclebase.org—a comprehensive multi-organism online database of cell-cycle experiments
emage—edinburgh mouse atlas of gene expression: 2008 update
many microbe microarrays database: uniformly normalized affymetrix compendia with structured experimental metadata
the stanford tissue microarray database
pride: new developments and new datasets
dbd––taxonomically broad transcription factor predictions: new content and functionality
an emerging cyberinfrastructure for biodefense pathogen and pathogen–host data
cebs—chemical effects in biological systems: a public data repository integrating study design and toxicity data with microarray and proteomics data
drugbank: a knowledgebase for drugs, drug actions and drug targets
glida: gpcr—ligand database for chemical genomics drug discovery—database and tools update
the pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge
supertarget and matador: resources for exploring drug-target relationships
violin: vaccine investigation and online information network
the plant organelles database (podb): a collection of visualized plant organelles and protocols for plant organelle research
dbtbs: a database of transcriptional regulation in bacillus subtilis containing upstream intergenic conservation information
mitome: dynamic and interactive database for comparative mitochondrial genomics in metazoan animals
the generation challenge programme comparative plant stress-responsive gene catalogue
gramene: a growing plant comparative genomics resource
metacrop: a detailed database of crop plant metabolism
plantgdb: a resource for comparative plant genomics
planttfdb: a comprehensive plant transcription factor database
dbtss: database of transcription start sites, progress report 200
planttribes: a gene and gene family resource for comparative genomics in plants
ppdb: a plant promoter database
update of asrp: the arabidopsis small rna project database
catdb: a public access to arabidopsis transcriptome data from the urgv-catma platform
greenphyldb: a database for plant comparative genomics
atpid: arabidopsis thaliana protein interactome database—an integrative platform for plant systems biology
protein evolution by hypermutation and selection in the b cell line dt4
sirna nanoformulation against the ret/ptc1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma
comprehensive viral oligonucleotide probe design using conserved protein regions
recombineering with tolc as a selectable/counter-selectable marker: remodeling the rrna operons of escherichia coli
from micrograms to picograms: quantitative pcr reduces the material demands of high-throughput sequencing
the translation of recombinant proteins in e. coli can be improved by in silico generating and screening random libraries of a –70/+96 mrna region with respect to ..
in situ oligonucleotide synthesis on carbon materials: stable substrates for microarray fabrication
genome wide screens in yeast to identify potential binding sites and target genes of dna-binding proteins
site-specific recombination in schizosaccharomyces pombe and systematic assembly of a 400kb transgene array in mammalian cells using the integrase of streptomyces p..
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