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核酸研究医学期刊2004年第02期封面 购买


rnase h2 of saccharomyces cerevisiae is a complex of three proteins
the major 5' determinant in stop codon read-through involves two adjacent adenines
specific inhibitors of hcv polymerase identified using an ns5b with lower affinity for template/primer substrate
formation of an intramolecular triple-stranded dna structure monitored by fluorescence of 2-aminopurine or 6-methylisoxanthopterin
exon repetition: a major pathway for processing mrna of some genes is allele-specific
statistical resynchronization and bayesian detection of periodically expressed genes
crystal structure of the catalytic fragment of murine poly(adp-ribose) polymerase-2
a primordial rna modification enzyme: the case of trna (m1a) methyltransferase
identification and characterization of two forms of mouse mutyh proteins encoded by alternatively spliced transcripts
premature termination codons enhance mrna decapping in human cells
synthesis of phosphorothioamidites derived from 3'-thio-3'-deoxythymidine and 3'-thio-2',3'-dideoxycytidine and the automated synthesis of oligodeoxynucleotides con..
more active human l1 retrotransposons produce longer insertions
interaction of saccharomyces cdc13p with pol1p, imp4p, sir4p and zds2p is involved in telomere replication, telomere maintenance and cell growth control
cassette-like variation of restriction enzyme genes in escherichia coli c and relatives
design and synthesis of a photocleavable biotinylated nucleotide for dna analysis by mass spectrometry
surprising features of plastid ndhd transcripts: addition of non-encoded nucleotides and polysome association of mrnas with an unedited start codon
protein structure prediction using sparse dipolar coupling data
automated correction of genome sequence errors
catalytic and dna-binding properties of the human ogg1 dna n-glycosylase/ap lyase: biochemical exploration of h270, q315 and f319, three amino acids of the 8-oxogua..
on the interpretation of raman spectra of 1-aminooxy-spermine/dna complexes
sequence-specific transcriptional repression by an mbd2-interacting zinc finger protein mizf
modification of de novo dna methyltransferase 3a (dnmt3a) by sumo-1 modulates its interaction with histone deacetylases (hdacs) and its capacity to repress transcri..
characterization of the 5'-untranslated region of yb-1 mrna and autoregulation of translation by yb-1 protein
linker phosphoramidite reagents for the attachment of the first nucleoside to underivatized solid-phase supports
functional analysis of subcellular localization and protein
nuclear mxa proteins form a complex with influenza virus np and inhibit the transcription of the engineered influenza virus genome
recognition of dna substrates by t4 bacteriophage polynucleotide kinase
poly(adp-ribose) polymerase (parp-1) and p53 independently function in regulating double-strand break repair in primate cells
targeting alzheimer’s disease genes with rna interference: an efficient strategy for silencing mutant alleles
guidelines for incorporating non-perfectly matched oligonucleotides into target-specific hybridization probes for a dna microarray
effects on rnai of the tight structure, sequence and position of the targeted region
the trypanosoma brucei spliced leader rna and rrna gene promoters have interchangeable tbsnap50-binding elements
a novel concept for ligand attachment to oligonucleotides via a 2'-succinyl linker
a new -interferon-inducible promoter and splice variants of an anti-angiogenic human trna synthetase
pcr amplification of dna containing non-standard base pairs by variants of reverse transcriptase from human immunodeficiency virus-1
fission yeast arp6 is required for telomere silencing, but functions independently of swi6
high-throughput protein analysis integrating bioinformatics and experimental assays
structure of a palindromic amplicon junction implicates microhomology-mediated end joining as a mechanism of sister chromatid fusion during gene amplification
transcription regulation of tnf--early response genes by poly(adp-ribose) polymerase-1 in murine heart endothelial cells
involvement of hus1 in the chain elongation step of dna replication after exposure to camptothecin or ionizing radiation
gene structure conservation aids similarity based gene prediction
a programmed
vito-1 is an essential cofactor of tef1-dependent muscle-specific gene regulation
recent horizontal intron transfer to a chloroplast genome
the sea urchin stem
probing alternative foldings of the hiv-1 leader rna by antisense oligonucleotide scanning arrays
2'-o-ethyl]-modified oligonucleotides inhibit expression of mrna in vitro and in vivo
role of the rna polymerase subunits in cii-dependent activation of the bacteriophage pe promoter: identification of important residues and positioning of the c-t..
two mutations in the tetracycline repressor change the inducer anhydrotetracycline to a corepressor
disruption of type iii secretion in salmonella enterica serovar typhimurium by external guide sequences
fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses
highly sensitive amperometric detection of genomic dna in animal tissues
rapid and accurate characterisation of short tandem repeats by maldi-tof analysis of endonuclease cleaved rna transcripts
a novel approach for evaluating the efficiency of sirnas on protein levels in cultured cells
rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor
construction of long dna molecules using long pcr-based fusion of several fragments simultaneously
impedance-based detection of dna sequences using a silicon transducer with pna as the probe layer
selective dna amplification from complex genomes using universal double-sided adapters
oligonucleotide-directed site-specific integration of high complexity libraries into ssdna templates
two-dimensional conformation-dependent electrophoresis (2d-cde) to separate dna fragments containing unmatched bulge from complex dna samples
structural and biochemical analyses of hemimethylated dna binding by the seqa protein
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