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《分子药理学杂志》2008年第03期

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combined effects of sulindac and suberoylanilide hydroxamic acid on apoptosis induction in human lung cancer cells
analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human cb1 receptor gene in t lymphocytes
inhibition of sodium channel gating by trapping the domain ii voltage sensor with protoxin ii
midazolam metabolism in cytochrome p450 3a knockout mice can be attributed to up-regulated cyp2c enzymes
progesterone acts via progesterone receptors a and b to regulate breast cancer resistance protein expression
distinctions between dopamine transporter antagonists could be just around the bend
ginsenoside rg3 inhibits human kv1.4 channel currents by interacting with the lys531 residue
antitumor mechanisms of systemically administered epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcino..
2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1h-isoindol-5-ylamino]-nicotinic acid (pd-307243) causes instantaneous current through human ether-a-go-go-related gene potas..
activation of the dual-leucine-zipper-bearing kinase and induction of β-cell apoptosis by the immunosuppressive drug cyclosporin a
identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (sult2a1)
potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids
caveolin regulates kv1.5 trafficking to cholesterol-rich membrane microdomains
a three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase ii inhibitors
derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human v2 vasopressin receptors
antitumorigenic effects of peroxisome proliferator-activated receptor- in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhib..
cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin
the two isoforms of the na+/ca2+ exchanger, ncx1 and ncx3, constitute novel additional targets for the prosurvival action of akt/protein kinase b pathway
inhibition of inducible nitric-oxide synthase protects human t cells from hypoxia-induced apoptosis
inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2c receptors: differential modulation of cell surface..
small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/camki pathway
interferon β augments tuberous sclerosis complex 2 (tsc2)-dependent inhibition of tsc2-null elt3 and human lymphangioleiomyomatosis-derived cell proliferation
molecular interactions of ccr5 with major classes of small-molecule anti-hiv ccr5 antagonists
activity and subcellular trafficking of the sodium-coupled choline transporter cht is regulated acutely by peroxynitrite
relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors
the telomeric protein trf2 is critical for the protection of a549 cells from both telomere erosion and dna double-strand breaks driven by salvicine
iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and t..
progesterone receptor (pr) isoforms pra and prb differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma bewo c..
an intracellular allosteric site for a specific class of antagonists of the cc chemokine g protein-coupled receptors ccr4 and ccr5
plasticity of adenylyl cyclase-related signaling sequelae after long-term morphine treatment
lipid composition alters drug action at the nicotinic acetylcholine receptor
identification of oxysterol 7-hydroxylase (cyp7b1) as a novel retinoid-related orphan receptor (ror) (nr1f1) target gene and a functional cross-talk between ror an..
identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes
n-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (cppha) acts through a novel site as a positive allosteric modulator of gro..
a novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression
insulin-like growth factor type-i receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not akt (protein kinase b) can be induced by p..
state- and use-dependent block of muscle nav1.4 and neuronal nav1.7 voltage-gated na+ channel isoforms by ranolazine
the breast cancer resistance protein (bcrp1/abcg2) limits fetal distribution of glyburide in the pregnant mouse: an obstetric-fetal pharmacology research unit netwo..
atomic force microscopy reveals the stoichiometry and subunit arrangement of the 4β3 gabaa receptor
modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor by dehydroepiandrosterone and other peroxisome proli..
n-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ica-27243): a novel, selective kcnq2/q3 potassium channel activator
a new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7h-indeno(2,1-c)quinolin-7-one dihydrochloride (tas-103) action discovered by target screening with d..
direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons
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