species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular 4 amino acids that are implicated in the coupling of bi..
sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor activity: a combined virtual screening and biological assay approach
acetaminophen recruits spinal p42/p44 mapks and gh/igf-1 receptors to produce analgesia via the serotonergic system
genomic screening in vivo reveals the role played by vacuolar h+ atpase and cytosolic acidification in sensitivity to dna-damaging agents such as cisplatin
the tumor proteasome is a primary target for the natural anticancer compound withaferin a isolated from "indian winter cherry"
rangap-mediated nuclear protein import in vascular smooth muscle cells is augmented by lysophosphatidylcholine
analysis of in vivo nuclear factor-b activation during liver inflammation in mice: prevention by catalase delivery
nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells
ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the 122l gabaa receptor
the synthetic androgen methyltrienolone (r1881) acts as a potent antagonist of the mineralocorticoid receptor
agonist-, antagonist-, and benzodiazepine-induced structural changes in the 1 met113-leu132 region of the gabaa receptor
kinins promote b2 receptor endocytosis and delay constitutive b1 receptor endocytosis
pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer
involvement of dopamine system in regulation of na+,k+-atpase in the striatum upon activation of opioid receptors by morphine
stabilization of cellular mrnas and up-regulation of proteins by oligoribonucleotides homologous to the bcl2 adenine-uridine rich element motif
tonically active gabaa receptors in hippocampal pyramidal neurons exhibit constitutive gaba-independent gating
an opioid agonist that does not induce µ-opioid receptor-arrestin interactions or receptor internalization
1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in lncap prostate cancer cells through pero..
2-aminoethoxydiphenyl borate directly inhibits channels composed of connexin26 and/or connexin32
nefiracetam potentiates n-methyl-d-aspartate (nmda) receptor function via protein kinase c activation and reduces magnesium block of nmda receptor
unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit -secretase and promote the neuronal differentiation of neuroblastoma cells
a pair-feeding study reveals that a y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure
inhibition of tumor necrosis factor--inducible inflammatory genes by interferon- is associated with altered nuclear factor-b transactivation and enhanced histone de..
functional involvement of multidrug resistance-associated protein 4 (mrp4/abcc4) in the renal elimination of the antiviral drugs adefovir and tenofovir
imino sugars are potent agonists of the human glucose sensor sglt3